Kathleen A. Pennington
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View article: A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism
A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism Open
Introduction Gestational Diabetes Mellitus (GDM) impacts roughly 1 in 7 pregnancies and results in metabolic dysfunction-associated steatotic liver disease (MASLD) in 30% of these women. Nonetheless, there exists a dearth of investigation …
View article: PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Maternal pre-pregnancy risks and postpartum consequences of gestational diabetes
PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Maternal pre-pregnancy risks and postpartum consequences of gestational diabetes Open
In brief Maternal morbidities both unmodifiable (genetics and prior history) and modifiable (insulin resistance and obesity) are associated with gestational diabetes. This review discusses common risk factors and postpartum consequences. A…
View article: The uterine secretome initiates growth of gynecologic tissues in ectopic locations
The uterine secretome initiates growth of gynecologic tissues in ectopic locations Open
Endosalpingiosis (ES) and endometriosis (EM) refer to the growth of tubal and endometrial epithelium respectively, outside of their site of origin. We hypothesize that uterine secretome factors drive ectopic growth. To test this, we develo…
View article: Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota
Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota Open
View article: Uterine secretome initiates growth of gynecologic tissues in ectopic locations
Uterine secretome initiates growth of gynecologic tissues in ectopic locations Open
Endosalpingiosis (ES) and endometriosis (EM) refer to the growth of tubal and endometrial epithelium respectively, outside of their site of origin. We hypothesize that uterine secretome factors drive ectopic growth. To test this, we develo…
View article: Gestational diabetes augments group B<i>Streptococcu</i>s perinatal infection through disruptions in maternal immunity and the vaginal microbiota
Gestational diabetes augments group B<i>Streptococcu</i>s perinatal infection through disruptions in maternal immunity and the vaginal microbiota Open
Group B Streptococcus (GBS) is a pervasive perinatal pathogen, yet factors driving GBS dissemination in utero are poorly defined. Gestational diabetes mellitus (GDM), a complication marked by dysregulated immunity and maternal microbial dy…
View article: Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice Open
Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2)…
View article: A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice
A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice Open
Gestational diabetes mellitus (GDM) affects 7–18% of all pregnancies. Despite its high prevalence, there is no widely accepted animal model. To address this, we recently developed a mouse model of GDM. The goal of this work was to further …
View article: Conditional knockout of leptin receptor in the female reproductive tract reduces fertility due to parturition defects in mice
Conditional knockout of leptin receptor in the female reproductive tract reduces fertility due to parturition defects in mice Open
Leptin is required for fertility, including initiation of estrous cycles. It is therefore challenging to assess the role of leptin signaling during pregnancy. Although neuron-specific transgene approaches suggest that leptin signaling in t…
View article: Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion
Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion Open
Gestational diabetes mellitus (GDM) is associated with defective pancreatic β-cell adaptation in pregnancy, but the underlying mechanism remains obscure. Our previous studies demonstrated that GDM women display increased plasma adrenomedul…
View article: Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice
Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice Open
View article: Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta
Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta Open
During pregnancy, the placenta is important for transporting nutrients and waste between the maternal and fetal blood supply, secreting hormones, and serving as a protective barrier. To better understand placental development, we must unde…
View article: Complement inhibitor Crry expression in mouse placenta is essential for maintaining normal blood pressure and fetal growth
Complement inhibitor Crry expression in mouse placenta is essential for maintaining normal blood pressure and fetal growth Open
Many circumstantial evidences from human and animal studies suggest that complement cascade dysregulation may play an important role in pregnancy associated complications including preeclampsia. Deletion of rodent specific complement inhib…
View article: Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet
Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet Open
View article: Changes in excitability and ion channel expression in neurons of the major pelvic ganglion in female type II diabetic mice
Changes in excitability and ion channel expression in neurons of the major pelvic ganglion in female type II diabetic mice Open
Bladder cystopathy is a common urological complication of diabetes, and has been associated with changes in parasympathetic ganglionic transmission and some measures of neuronal excitability in male mice. To determine whether type II diabe…
View article: In Utero and Postnatal Exposure to High Fat, High Sucrose Diet Suppressed Testis Apoptosis and Reduced Sperm Count
In Utero and Postnatal Exposure to High Fat, High Sucrose Diet Suppressed Testis Apoptosis and Reduced Sperm Count Open
View article: Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice†
Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice† Open
Gestational diabetes mellitus (GDM) is a common obstetric complication. Half of women who have GDM will go on to develop type 2 diabetes. Understanding the mechanisms by which this occurs requires an animal model of GDM without ongoing dia…
View article: 602: Impaired expression of genes involved in glucose and lipid metabolism in non-obese GDM mouse model
602: Impaired expression of genes involved in glucose and lipid metabolism in non-obese GDM mouse model Open
View article: Maternal Hyperleptinemia Is Associated with Male Offspring’s Altered Vascular Function and Structure in Mice
Maternal Hyperleptinemia Is Associated with Male Offspring’s Altered Vascular Function and Structure in Mice Open
Children of mothers with gestational diabetes have greater risk of developing hypertension but little is known about the mechanisms by which this occurs. The objective of this study was to test the hypothesis that high maternal concentrati…
View article: Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice
Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice Open
Maternal obesity and gestational diabetes are prevalent worldwide. Offspring of mothers with these conditions weigh more and are predisposed to metabolic syndrome. A hallmark of both conditions is maternal hyperleptinemia, but the role of …
View article: Maternal Hyperleptinemia Increases Arterial Stiffening and Alters Vasodilatoy Responses to Insulin in Adult Male Mice Offspring
Maternal Hyperleptinemia Increases Arterial Stiffening and Alters Vasodilatoy Responses to Insulin in Adult Male Mice Offspring Open
Cardiovascular disease (CVD) is the number one cause of death in the U.S., and exposure to adverse maternal environments has been associated with the development of CVD including hypertension. Gestational diabetes mellitus (GDM) is an adve…
View article: Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice
Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice Open
Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are a…
View article: Placental changes caused by food restriction during early pregnancy in mice are reversible
Placental changes caused by food restriction during early pregnancy in mice are reversible Open
In a previous study, 50% calorie restriction in mice from d1.5 to 11.5 of pregnancy resulted in reduced placental weights and areas, relativel sparing of labyrinth zone area compared to junctional zone area, and dramatic changes in global …