Kathleen E. Prosser
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View article: Further correction: Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery
Further correction: Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery Open
Further correction for ‘Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery’ by Christine N. Morrison et al. , Chem. Sci. , 2020, 11 , 1216–1225, https://doi.org/10.1039/C9SC05586…
View article: CCDC 2205012: Experimental Crystal Structure Determination
CCDC 2205012: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2205011: Experimental Crystal Structure Determination
CCDC 2205011: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Correction: <sup>19</sup>F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes
Correction: <sup>19</sup>F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes Open
Correction for ‘ 19 F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes’ by Kathleen E. Prosser et al. , Chem. Commun. , 2021, 57 , 4934–4937, DOI: 10.1039/D1CC01231B.
View article: Correction: Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery
Correction: Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery Open
Correction for ‘Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery’ by Christine N. Morrison et al. , Chem. Sci. , 2020, 11 , 1216–1225, https://doi.org/10.1039/C9SC05586J.
View article: Evaluating Metal–Ligand Interactions of Metal-Binding Isosteres Using Model Complexes
Evaluating Metal–Ligand Interactions of Metal-Binding Isosteres Using Model Complexes Open
Bioisosteres are a useful approach to address pharmacokinetic liabilities and improve drug-like properties. Specific to developing metalloenzyme inhibitors, metal-binding pharmacophores (MBPs) have been combined with bioisosteres, to produ…
View article: CCDC 1838680: Experimental Crystal Structure Determination
CCDC 1838680: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: <sup>19</sup>F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes
<sup>19</sup>F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes Open
This study demonstrates the screening of a collection of twelve 19F-tagged metal-binding pharmacophores (MBPs) against the Zn(ii)-dependent metalloenzyme human carbonic anhydrase II (hCAII) by 19F NMR.
View article: Evaluation of 3-Dimensionality in Approved and Experimental Drug Space
Evaluation of 3-Dimensionality in Approved and Experimental Drug Space Open
The 3-dimensional (3D) structure of therapeutics and other bioactive molecules is an important factor in determining the strength and selectivity of their protein-ligand interactions. Previous efforts have considered the strain introduced …
View article: Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery
Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery Open
Fragment-based drug discovery (FBDD) using 3-dimensional metallofragments is a new strategy for the identification of bioactive molecules.
View article: A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation
A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation Open
An Fe corrole is shown to bind to the amyloid-beta peptide and limit reactive oxygen species generation and peptide aggregation of relevance to Alzheimer's disease.
View article: CCDC 1863411: Experimental Crystal Structure Determination
CCDC 1863411: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863409: Experimental Crystal Structure Determination
CCDC 1863409: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863416: Experimental Crystal Structure Determination
CCDC 1863416: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863413: Experimental Crystal Structure Determination
CCDC 1863413: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863415: Experimental Crystal Structure Determination
CCDC 1863415: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863410: Experimental Crystal Structure Determination
CCDC 1863410: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863408: Experimental Crystal Structure Determination
CCDC 1863408: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863414: Experimental Crystal Structure Determination
CCDC 1863414: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1863412: Experimental Crystal Structure Determination
CCDC 1863412: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1448641: Experimental Crystal Structure Determination
CCDC 1448641: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1448640: Experimental Crystal Structure Determination
CCDC 1448640: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1428923: Experimental Crystal Structure Determination
CCDC 1428923: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1423575: Experimental Crystal Structure Determination
CCDC 1423575: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1423574: Experimental Crystal Structure Determination
CCDC 1423574: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …