Kathleen Klaper
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View article: Autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae in Germany, 2025
Autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae in Germany, 2025 Open
We report four confirmed autochthonously transmitted gonorrhoea cases in Germany in 2025, with Neisseria gonorrhoeae isolates exhibiting high-level azithromycin and cefixime resistance. Regarding ceftriaxone, isolates were susceptible for …
View article: Enhanced invasion and survival of antibiotic- resistant Klebsiella pneumoniae pathotypes in host cells and strain-specific replication in blood
Enhanced invasion and survival of antibiotic- resistant Klebsiella pneumoniae pathotypes in host cells and strain-specific replication in blood Open
Background Klebsiella pneumoniae is one of the most important opportunistic pathogens causing healthcare-associated and community-acquired infections worldwide. In recent years, the increase in antibiotic resistance and infections caused b…
View article: Presence of hypervirulence-associated determinants in Klebsiella pneumoniae from hospitalised patients in Germany
Presence of hypervirulence-associated determinants in Klebsiella pneumoniae from hospitalised patients in Germany Open
Our study results show that K. pneumoniae strains that carry several determinants of hypervirulence are present for many years in Germany. The detection of carbapenemase genes and hypervirulence associated genes on the same plasmid is high…
View article: Integrated molecular, phenotypic and epidemiological surveillance of antimicrobial resistance in Neisseria gonorrhoeae in Germany
Integrated molecular, phenotypic and epidemiological surveillance of antimicrobial resistance in Neisseria gonorrhoeae in Germany Open
Numbers of infections with Neisseria gonorrhoeae are among the top three sexually transmitted infections (STI) worldwide. In addition, the emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae pose an important pu…
View article: Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics
Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics Open
Hypervirulent Klebsiella pneumoniae strains (hvKp) can cause invasive community-acquired infections in healthy patients of all ages. In this study, the prevalence of putative hvKp in a German tertiary center was investigated and hvKp were …
View article: 1358. Establishing Genomic SARS-CoV-2 Surveillance at the National Level: Germany, 2021
1358. Establishing Genomic SARS-CoV-2 Surveillance at the National Level: Germany, 2021 Open
Background The COVID-19 pandemic has demonstrated the importance of pathogen genomic surveillance. At RKI, the German National Institute of Public Health, we established the Integrated Molecular Surveillance for SARS-CoV-2 (IMS-SC2) networ…
View article: Advancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021
Advancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021 Open
Background Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track the spread of this an…
View article: Transmission of SARS-CoV-2 among children and staff in German daycare centres
Transmission of SARS-CoV-2 among children and staff in German daycare centres Open
In daycare centres, the close contact of children with other children and employees favours the transmission of infections. The majority of children <6 years attend daycare programmes in Germany, but the role of daycare centres in the SARS…
View article: Transmission of SARS-CoV-2 among children and staff in German daycare centers: results from the COALA study
Transmission of SARS-CoV-2 among children and staff in German daycare centers: results from the COALA study Open
Background Whereas the majority of children under 6 years of age attend daycare centers in Germany, evidence on the role of daycare centers in the transmission of SARS-CoV-2 is scarce. Aims This study aims to investigate the transmission r…
View article: Genome-Based Analysis of Klebsiella spp. Isolates from Animals and Food Products in Germany, 2013–2017
Genome-Based Analysis of Klebsiella spp. Isolates from Animals and Food Products in Germany, 2013–2017 Open
The increase in infections with multidrug-resistant and virulent Klebsiella pneumoniae (K. pneumoniae) strains poses a serious threat to public health. However, environmental reservoirs and routes of transmission for Klebsiella spp. that c…
View article: Hypervirulent Klebsiella pneumoniae of Lineage ST66-K2 Caused Tonsillopharyngitis in a German Patient
Hypervirulent Klebsiella pneumoniae of Lineage ST66-K2 Caused Tonsillopharyngitis in a German Patient Open
Hypervirulent Klebsiella pneumoniae (hvKp) is a novel pathotype that has been rarely described in Europe. This study characterizes a hvKp isolate that caused a community-acquired infection. The hypermucoviscous Klebsiella pneumoniae (K. pn…
View article: Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019 Open
From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapen…