Kathleen M. Fisch
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View article: Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells
Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells Open
Abnormal decidual natural killer cell (dNK) function is linked to pregnancy complications occurring in both early and late stages of gestation, including recurrent pregnancy loss, preeclampsia, and preterm birth. Exploration of dNK heterog…
View article: Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment
Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment Open
Polycomb Repressive Complexes (PRCs) are known for chemically modifying histones to compact chromatin structure and repress transcription. Broadly speaking, PRC1 monoubiquitinates histone 2A at lysine 119 (H2AK119ub), and PRC2 methylates h…
View article: Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy
Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy Open
SUMMARY High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in the USA due to chemo- and immuno-therapy resistance. We show that focal adhesion kinase (FAK) inhibition with ifebemtinib or tumor genetic FAK kn…
View article: Human Placental Genomic Instability Predicts Adverse Pregnancy Outcomes
Human Placental Genomic Instability Predicts Adverse Pregnancy Outcomes Open
Preeclampsia is a leading cause of pregnancy-related death, accounting for over 50,000 maternal and 500,000 fetal deaths worldwide each year. Preeclampsia has been linked to confined placental mosaicism, which underscores a potential role …
View article: Dysregulation of huntingtin interacting protein networks in human juvenile Huntington's disease brain
Dysregulation of huntingtin interacting protein networks in human juvenile Huntington's disease brain Open
Background Human Huntington's disease (HD) is a genetic neurodegenerative disorder caused by the mutant HTT gene containing CAG repeat expansions, resulting in motor dysfunction and behavioral deficits. CAG repeats of 40–53 occur in adult …
View article: Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells
Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells Open
View article: VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment Open
The trophectoderm (TE), the first lineage specified during mammalian development, initiates implantation and gives rise to placental trophoblasts. While animal models have elucidated key conserved signaling pathways involved in early TE sp…
View article: Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer
Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer Open
Extrachromosomal circular DNA (ecDNA) has been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC). However…
View article: Induction of MASH in three-dimensional bioprinted human liver tissue
Induction of MASH in three-dimensional bioprinted human liver tissue Open
Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (MASH), is a major risk factor for cirrhosis and hepatocellular carcinoma (HCC) and a leading cause of liver transplantation. MASH is c…
View article: Associations Between Social Determinants of Health and Opioid-Use Disorder Among Chronic Pain Patients From a Multi-Institutional Dataset
Associations Between Social Determinants of Health and Opioid-Use Disorder Among Chronic Pain Patients From a Multi-Institutional Dataset Open
BACKGROUND: This study examined the association between opioid-use disorder (OUD)-related diagnoses (eg, opioid dependence) and social determinants of health (SDoH) among patients with chronic pain. METHODS: A cross-sectional study was per…
View article: The Association of Social Determinants of Health With Reported Daily Pain Scores Among Patients With a History of Chronic Pain Using the “All of Us” Research Program
The Association of Social Determinants of Health With Reported Daily Pain Scores Among Patients With a History of Chronic Pain Using the “All of Us” Research Program Open
View article: Inhibition of novel human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer
Inhibition of novel human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer Open
Extrachromosomal circular DNA (ecDNA) have been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC). Howeve…
View article: RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection
RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection Open
Adenosine to inosine (A-to-I) RNA editing by ADAR1 has been implicated in maintaining self-tolerance, preventing autoimmunity, and mediating antiviral immunity. Foreign viral double-stranded RNA triggers rapid interferon response and activ…
View article: Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells
Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells Open
Cytotrophoblast (CTB) of the early gestation human placenta are bipotent progenitor epithelial cells, which can differentiate into invasive extravillous trophoblast (EVT) and multinucleated syncytiotrophoblast (STB). Trophoblast stem cells…
View article: Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues
Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues Open
Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been u…
View article: PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections Open
Virulent infectious agents such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methicillin-resistant Staphylococcus aureus (MRSA) induce tissue damage that recruits neutrophils, monocyte, and macrophages, leading to T …
View article: The genomic landscape of Ménière's disease: a path to endolymphatic hydrops
The genomic landscape of Ménière's disease: a path to endolymphatic hydrops Open
Background Ménière's disease (MD) is a disorder of the inner ear that causes episodic bouts of severe dizziness, roaring tinnitus, and fluctuating hearing loss. To date, no targeted therapy exists. As such, we have undertaken a large whole…
View article: Comprehensive next-generation sequencing identifies novel putative pathogenic or likely pathogenic germline variants in patients with concurrent tubo-ovarian and endometrial serous and endometrioid carcinomas or precursors
Comprehensive next-generation sequencing identifies novel putative pathogenic or likely pathogenic germline variants in patients with concurrent tubo-ovarian and endometrial serous and endometrioid carcinomas or precursors Open
View article: Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia
Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia Open
Fetal and neonatal exposures to perinatal oxidative stress (OS) are key mediators of bronchopulmonary dysplasia (BPD). To characterize these exposures, adductomics is an exposure science approach that captures electrophilic addition produc…
View article: Chronic villitis as a distinctive feature of placental injury in maternal SARS-CoV-2 infection
Chronic villitis as a distinctive feature of placental injury in maternal SARS-CoV-2 infection Open
Chronic villitis seems to be the most specific histopathologic finding associated with SARS-CoV-2 maternal infection. Chronic villitis involves damage to the vasculosyncytial membrane of the chorionic villi, which are involved in gas and n…
View article: Nuclear morphology is shaped by loop-extrusion programs
Nuclear morphology is shaped by loop-extrusion programs Open
View article: Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing
Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing Open
Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches. Here, we show t…
View article: Integrated Genomic and Social Network Analyses of SARS-CoV-2 Transmission in the Healthcare Setting
Integrated Genomic and Social Network Analyses of SARS-CoV-2 Transmission in the Healthcare Setting Open
Background Infection prevention (IP) measures are designed to mitigate the transmission of pathogens in healthcare. Using large-scale viral genomic and social network analyses, we determined if IP measures used during the severe acute resp…
View article: Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape
Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape Open
Introduction Female reproductive function depends on a choreographed sequence of hormonal secretion and action, where specific stresses such as inflammation exert profound disruptions. Specifically, acute LPS-induced inflammation inhibits …
View article: GWAS OF BRAIN ENDOPHENOTYPES: ASSOCIATION OF AUTOPSY-BASED LEWY BODY COUNTS WITH MOVEMENT DISORDER RISK LOCI
GWAS OF BRAIN ENDOPHENOTYPES: ASSOCIATION OF AUTOPSY-BASED LEWY BODY COUNTS WITH MOVEMENT DISORDER RISK LOCI Open
We performed a genome wide association study (GWAS) of neocortical Lewy body density. Case material were 308 autopsies of Japanese-American men (mean age at death 87.5 years; 11% with mild, and 30% with severe cognitive impairment prior to…
View article: PLACENTAL MUTATIONAL BURDEN NEGATIVELY CORRELATES WITH GESTATIONAL AGE IN EARLY-ONSET PREECLAMPSIA
PLACENTAL MUTATIONAL BURDEN NEGATIVELY CORRELATES WITH GESTATIONAL AGE IN EARLY-ONSET PREECLAMPSIA Open
The placenta exists in a hypoxic environment during early pregnancy, making it susceptible to somatic genetic mutations caused by oxidative stress and rapid cell proliferation. Oxidative stress is one of the leading factors involved in cel…
View article: Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics
Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics Open
View article: Resident microbes shape the vaginal epithelial glycan landscape
Resident microbes shape the vaginal epithelial glycan landscape Open
Epithelial cells are covered in carbohydrates (glycans). This glycan coat or “glycocalyx” interfaces directly with microbes, providing a protective barrier against potential pathogens. Bacterial vaginosis (BV) is a condition associated wit…
View article: Defining the relationship of salivary gland malignancies to novel cell subpopulations in human salivary glands using single nucleus <scp>RNA</scp>‐sequencing
Defining the relationship of salivary gland malignancies to novel cell subpopulations in human salivary glands using single nucleus <span>RNA</span>‐sequencing Open
Salivary glands have essential roles in maintaining oral health, mastication, taste and speech, by secreting saliva. Salivary glands are composed of several types of cells, and each cell type is predicted to be involved in the carcinogenes…
View article: High placental expression of FLT1, LEP, PHYHIP and IL3RA – In persons of African ancestry with severe preeclampsia
High placental expression of FLT1, LEP, PHYHIP and IL3RA – In persons of African ancestry with severe preeclampsia Open