Kathleen N. Potter
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View article: Towards Clinical Prediction with Transparency: An Explainable AI Approach to Survival Modelling in Residential Aged Care
Towards Clinical Prediction with Transparency: An Explainable AI Approach to Survival Modelling in Residential Aged Care Open
Background: Accurate survival time estimates aid end-of-life medical decision-making. Objectives: Develop an interpretable survival model for elderly residential aged care residents using advanced machine learning. Setting: A major Austral…
View article: Deprescribing to optimise health outcomes for frail older people: a double-blind placebo-controlled randomised controlled trial—outcomes of the Opti-med study
Deprescribing to optimise health outcomes for frail older people: a double-blind placebo-controlled randomised controlled trial—outcomes of the Opti-med study Open
Background potentially harmful polypharmacy is very common in older people living in aged care facilities. To date, there have been no double-blind randomised controlled studies of deprescribing multiple medications. Methods three-arm (ope…
View article: Deprescribing considerations for older people in general practice
Deprescribing considerations for older people in general practice Open
Deprescribing is a safe and effective method of reducing polypharmacy and high-risk prescribing. The challenge for GPs in deprescribing medicines for older people is to avoid adverse drug withdrawal events. Strategies to deprescribe confid…
View article: High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL
High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL Open
Chronic lymphocytic leukemia (CLL) cells have variably low surface IgM (sIgM) levels/signaling capacity, influenced by chronic antigen engagement at tissue sites. Within these low levels, CLL with relatively high sIgM (CLLhigh) progresses …
View article: Single-nucleotide Fcγ receptor polymorphisms do not impact obinutuzumab/rituximab outcome in patients with lymphoma
Single-nucleotide Fcγ receptor polymorphisms do not impact obinutuzumab/rituximab outcome in patients with lymphoma Open
Single-nucleotide polymorphisms (SNPs) have been shown to influence Fcγ receptor (FcγR) affinity and activity, but their effect on treatment response is unclear. We assessed their importance in the efficacy of obinutuzumab or rituximab com…
View article: Prognostic significance of <i>FCGR2B</i> expression for the response of DLBCL patients to rituximab or obinutuzumab treatment
Prognostic significance of <i>FCGR2B</i> expression for the response of DLBCL patients to rituximab or obinutuzumab treatment Open
Fc γ receptor IIB (FcγRIIB) is an inhibitory molecule capable of reducing antibody immunotherapy efficacy. We hypothesized its expression could confer resistance in patients with diffuse large B-cell lymphoma (DLBCL) treated with anti-CD20…
View article: Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study
Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study Open
BACKGROUND: Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrogate markers of pro…
View article: A concept analysis of deprescribing medications in older people
A concept analysis of deprescribing medications in older people Open
Aim Deprescribing is an increasingly common term in the literature, although no specific accepted definition exists. We aimed to clarify the concept of deprescribing as used in research and clinical practice. Methods Deprescribing was exam…
View article: P238 A pilot study on the prevalence of obstructed defaecation syndrome among female patients of an inflammatory bowel disease cohort
P238 A pilot study on the prevalence of obstructed defaecation syndrome among female patients of an inflammatory bowel disease cohort Open
Obstructed defaecation syndrome(ODS) is a complex mechanical-functional disorder leading to difficult or inadequate rectal emptying. Prevalence ranges from 3.4% in the general population up to 23% in middle-aged women. However, the prevale…
View article: Additional file 1: of Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study
Additional file 1: of Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study Open
Sections 1A and 1B presenting POSH Serum Procurement SOPs. (ZIP 244 kb)
View article: Exploring the enablers and barriers to implementing the Medication Appropriateness Tool for Comorbid Health conditions during Dementia (MATCH-D) criteria in Australia: a qualitative study
Exploring the enablers and barriers to implementing the Medication Appropriateness Tool for Comorbid Health conditions during Dementia (MATCH-D) criteria in Australia: a qualitative study Open
Objectives The Medication Appropriateness Tool for Comorbid Health conditions in Dementia (MATCH-D) criteria provide expert consensus guidance about medication use for people with dementia. This study aimed to identify enablers and barrier…
View article: DEPRESCRIBING IN FRAIL OLDER PEOPLE
DEPRESCRIBING IN FRAIL OLDER PEOPLE Open
Deprescribing has been proposed as a way to reduce polypharmacy in frail older people, and may improve their survival. We have conducted two randomised controlled trials (RCT) and a systematic review examining deprescribing, the planned ce…
View article: Issue Information
Issue Information Open
From Le Roux AB, et al.Transverse ultrasonographic (A) and histopathologic (B, C) images of the jejunum from a
View article: Medication appropriateness tool for co‐morbid health conditions in dementia: consensus recommendations from a multidisciplinary expert panel
Medication appropriateness tool for co‐morbid health conditions in dementia: consensus recommendations from a multidisciplinary expert panel Open
Background Medication management for people living with dementia is a complex task as it is unclear what constitutes optimal medication management in this population due to the shifting focus of health priorities and the balance between th…
View article: The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis
The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis Open
Aims Deprescribing is a suggested intervention to reverse the potential iatrogenic harms of inappropriate polypharmacy. The review aimed to determine whether or not deprescribing is a safe, effective and feasible intervention to modify mor…
View article: Correction: Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus
Correction: Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus Open
Fig 4 is incorrect. The figure is an older version, which contains an inaccurate summary of data. The authors have provided a corrected version here.
Fig 4
Performance of FcγR -targeted probes in healthy donors.
View article: Deprescribing in Frail Older People: A Randomised Controlled Trial
Deprescribing in Frail Older People: A Randomised Controlled Trial Open
Australian New Zealand Clinical Trials Registry ACTRN12611000370909.
View article: Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus
Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus Open
Cancer immunotherapy has been revolutionised by the use monoclonal antibodies (mAb) that function through their interaction with Fc gamma receptors (FcγRs). The low-affinity FcγR genes are highly homologous, map to a complex locus at 1p23 …
View article: Prescribing for Australians living with dementia: study protocol using the Delphi technique
Prescribing for Australians living with dementia: study protocol using the Delphi technique Open
Introduction Prescribing is complicated for people living with dementia, and careful consideration should be given to continuing and initiating all medicines. This study aims to elicit opinion and gain consensus on appropriate medicine use…
View article: Reducing Inappropriate Polypharmacy
Reducing Inappropriate Polypharmacy Open
Inappropriate polypharmacy, especially in older people, imposes a substantial burden of adverse drug events, ill health, disability, hospitalization, and even death. The single most important predictor of inappropriate prescribing and risk…