Kathrin Jobski
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View article: Change of antidepressant utilization in children, adolescents and young adults in Europe before and during the COVID-19 pandemic: a systematic review
Change of antidepressant utilization in children, adolescents and young adults in Europe before and during the COVID-19 pandemic: a systematic review Open
Background In recent decades, antidepressant utilization among young persons in Western countries has increased, raising concerns about overprescribing and safety. The COVID-19 pandemic and respective restrictions might have impacted not o…
View article: Urinary tract infection in outpatients in Germany – a cross-sectional study of diagnostics and susceptibility testing in medical laboratories
Urinary tract infection in outpatients in Germany – a cross-sectional study of diagnostics and susceptibility testing in medical laboratories Open
Background Urinary tract infections (UTIs) are common, representing a frequent cause of antibiotic prescription in primary care worldwide. Selection of antibiotics for antimicrobial susceptibility testing and the reporting of test results …
View article: Methotrexate-related drug reactions on kidneys and liver in rheumatoid arthritis: an analysis of spontaneous reports in EudraVigilance
Methotrexate-related drug reactions on kidneys and liver in rheumatoid arthritis: an analysis of spontaneous reports in EudraVigilance Open
Objective Methotrexate (MTX), a standard treatment for rheumatoid arthritis (RA), is known for its potential kidney and liver toxicity. Whether concomitant use of analgesics, possibly affecting the same organs, has an impact on the occurre…
View article: Pain intensity and comorbid depressive symptoms in the general population: An analysis of the German Health Update Study (GEDA 2019/2020‐EHIS)
Pain intensity and comorbid depressive symptoms in the general population: An analysis of the German Health Update Study (GEDA 2019/2020‐EHIS) Open
Background Pain and depressive symptoms often co‐occur, but the influence of pain intensity remains unclear. This study analyses the association between pain intensity and depressive symptoms in the general adult German population. Methods…
View article: Characteristics and completeness of spontaneous reports by reporter's role in Germany: An analysis of the <scp>EudraVigilance</scp> database using the example of opioid‐associated abuse, dependence, or withdrawal
Characteristics and completeness of spontaneous reports by reporter's role in Germany: An analysis of the <span>EudraVigilance</span> database using the example of opioid‐associated abuse, dependence, or withdrawal Open
Spontaneous reporting is based on the experience of all healthcare professionals (HCPs) but also consumers/non‐HCPs and therefore reveals a broad picture of a drug's adverse reactions. Recent studies found substantial differences between r…
View article: Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe
Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe Open
View article: Patterns and trends of antibacterial treatment in patients with urinary tract infections, 2015–2019: an analysis of health insurance data
Patterns and trends of antibacterial treatment in patients with urinary tract infections, 2015–2019: an analysis of health insurance data Open
View article: Nurse-Filled versus Pharmacy-Filled Medication Organization Devices—Survey on Current Practices and Views of Home Care Nursing Services
Nurse-Filled versus Pharmacy-Filled Medication Organization Devices—Survey on Current Practices and Views of Home Care Nursing Services Open
Medication organization devices (MODs) are widely used among home care nursing services. However, current practices such as the responsibility for filling MODs, different MOD types used and requirements of home care nursing services are la…
View article: Erratum zu: Epistaxis und antithrombotische Medikation: eine Analyse der Daten einer gesetzlichen Krankenversicherung in Niedersachsen
Erratum zu: Epistaxis und antithrombotische Medikation: eine Analyse der Daten einer gesetzlichen Krankenversicherung in Niedersachsen Open
Die Epistaxis ist ein haufiges Symptom in der Arztpraxis und assoziiert mit verschiedenen Komorbiditaten und Medikamenten, insbesondere Antikoagulanzien. Trotz ihrer Alltaglichkeit gibt es nur wenige Daten zur Haufigkeit ihres Auftreten…
View article: Treating epistaxis – who cares for a bleeding nose? A secondary data analysis of primary and secondary care
Treating epistaxis – who cares for a bleeding nose? A secondary data analysis of primary and secondary care Open
View article: Global <scp>COVID</scp>‐19 pandemic and reporting behavior ‐ An analysis of the Food and Drug Administration adverse events reporting system
Global <span>COVID</span>‐19 pandemic and reporting behavior ‐ An analysis of the Food and Drug Administration adverse events reporting system Open
Purpose To describe the characteristics of adverse event reporting in the United States (US) Food and Drug Administration Adverse Event Reporting System (FAERS) before and after the outbreak of the COVID‐19 pandemic. Methods We included al…
View article: Tyrosine kinase inhibitors targeting vascular endothelial growth factor and the risk of aortic dissection—A pharmacovigilance analysis
Tyrosine kinase inhibitors targeting vascular endothelial growth factor and the risk of aortic dissection—A pharmacovigilance analysis Open
There are concerns by the United States Food and Drug Administration (FDA) regarding a potential link between tyrosine kinase inhibitors targeting vascular endothelial growth factor (VEGF‐TKIs) and the risk of aortic dissection. Elevation …
View article: Different Risk Profiles of European Patients Using Direct Oral Anticoagulants or Vitamin K Antagonists: a Rapid Review
Different Risk Profiles of European Patients Using Direct Oral Anticoagulants or Vitamin K Antagonists: a Rapid Review Open
Purpose of Review We investigated the risk profiles of patients using direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) in European cohort studies to estimate the importance of potential (measured or unmeasured) confounding …
View article: <p>Regional Differences in Opioid Prescribing in Germany – Results of an Analysis of Health Insurance Data of 57 Million Adult People</p>
Regional Differences in Opioid Prescribing in Germany – Results of an Analysis of Health Insurance Data of 57 Million Adult People Open
We found large regional variations in opioid prescribing which probably cannot only be attributed to differences in patient characteristics.
View article: Regional Differences in Opioid Prescribing in Germany – Results of an Analysis of Health Insurance Data of 57 Million Adult People
Regional Differences in Opioid Prescribing in Germany – Results of an Analysis of Health Insurance Data of 57 Million Adult People Open
Kathrin Jobski,1 Michael Dörks,1 Carsten Bantel,2 Falk Hoffmann1 1Department of Health Services Research, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; 2University Department of Anesthesiology, Critical Care, Emergency and P…
View article: Epistaxis und antithrombotische Medikation: eine Analyse der Daten einer gesetzlichen Krankenversicherung in Niedersachsen
Epistaxis und antithrombotische Medikation: eine Analyse der Daten einer gesetzlichen Krankenversicherung in Niedersachsen Open
View article: Regional Differences in Prescribing Patterns of Metamizole in Germany Based on Data from 70 Million Persons
Regional Differences in Prescribing Patterns of Metamizole in Germany Based on Data from 70 Million Persons Open
The non-opioid analgesic metamizole (dipyrone) is commonly used in Germany despite its narrow indications and market withdrawal from several countries. In this study we analyzed prescribing patterns of metamizole focusing on regional diffe…
View article: <p>Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data</p>
Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data Open
Gabapentinoids were frequently used in nursing home residents. Regular co-prescribing with opioids and psychotropic drugs might indicate employment to improve pain or assist treatment of conditions that are frequently associated with disru…
View article: Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data
Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data Open
C Bantel,1,2 F Hoffmann,3 K Jobski3 1Department of Anesthesiology, Critical Care, Emergency and Pain Medicine, Universität Oldenburg, Klinikum Oldenburg, Oldenburg, Germany; 2Department of Surgery & Cancer, Anaesthetics Section, Imperial C…
View article: Agranulocytosis attributed to metamizole: An analysis of spontaneous reports in EudraVigilance 1985‐2017
Agranulocytosis attributed to metamizole: An analysis of spontaneous reports in EudraVigilance 1985‐2017 Open
Despite ongoing debates about its safety, the use of metamizole (dipyrone) is still increasing in many countries. In this study, we analysed spontaneous reports of suspected metamizole‐associated agranulocytosis recorded in EudraVigilance …
View article: Healthcare provision, functional ability and quality of life after proximal femoral fracture - ’ProFem': Study protocol of a population-based, prospective study based on individually linked survey and statutory health insurance data
Healthcare provision, functional ability and quality of life after proximal femoral fracture - ’ProFem': Study protocol of a population-based, prospective study based on individually linked survey and statutory health insurance data Open
Introduction Proximal femoral fractures (PFF) are among the most frequent fractures in older people. However, the situation of people with a PFF after hospital discharge is poorly understood. Our aim is to (1) analyse healthcare provision,…
View article: Antidepressants and the risk of death in older patients with depression: A population-based cohort study
Antidepressants and the risk of death in older patients with depression: A population-based cohort study Open
This study suggests that ADs recommended as first-line treatment in patients with depression have a similar safety profile with regard to the risk of death, especially in very old patients and in those with dementia. Further research is ne…
View article: Combined use of drugs inhibiting the renin–angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents
Combined use of drugs inhibiting the renin–angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents Open
Michael Dörks,1 Stefan Herget-Rosenthal,2 Falk Hoffmann,1 Kathrin Jobski1 1Department of Health Services Research, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; 2Department of Medicine, Rotes Kreuz Krankenhaus, Bremen, Germa…
View article: Combined use of drugs inhibiting the renin&ndash;angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents
Combined use of drugs inhibiting the renin–angiotensin system: prescribing patterns and risk of acute kidney injury in German nursing home residents Open
Prescribing of drugs inhibiting the RAS is common in German nursing homes. Though the prevalence of dual RAS blockade declined, our study showed an increased risk of AKI in patients with diabetes and/or chronic kidney disease. Therefore, c…
View article: Use of oral anticoagulants in German nursing home residents: drug use patterns and predictors for treatment choice
Use of oral anticoagulants in German nursing home residents: drug use patterns and predictors for treatment choice Open
Aims Information on utilization of oral anticoagulants (OACs) in nursing homes is scarce. This study aimed to (i) describe OAC use in German nursing home residents, (ii) examine factors influencing whether treatment is initiated with vitam…
View article: The impact of the lookback period and definition of confirmatory events on the identification of incident cancer cases in administrative data
The impact of the lookback period and definition of confirmatory events on the identification of incident cancer cases in administrative data Open
The choice of lookback and confirmation periods and the definition of confirmatory events have considerable impact on the number of incident cancer cases identified and ACI estimated. Researchers need to be aware of potential misclassifica…
View article: Risk of venous thromboembolism in cancer patients treated with epoetins or blood transfusions
Risk of venous thromboembolism in cancer patients treated with epoetins or blood transfusions Open
Aims Anaemia is common in cancer patients, with treatments including epoetins and blood transfusions. Although an increased risk of venous thromboembolism (VTE) has been associated with both therapeutics, studies comparing the risk of VTE …
View article: Methodische Aspekte bei der Durchführung von Arzneimittelsicherheits- und Utilisationsstudien basierend auf Routinedaten der gesetzlichen Krankenversicherung
Methodische Aspekte bei der Durchführung von Arzneimittelsicherheits- und Utilisationsstudien basierend auf Routinedaten der gesetzlichen Krankenversicherung Open
At the time of approval, the safety and utilization of drugs in routine clinical practice cannot be fully assessed. Therefore, active post-marketing surveillance including the determination of the safety but also the utilization of the dru…