Kathrin Möllenhoff
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View article: Severe Hyponatremia in the Emergency Department Incidence of Cerebral Edema and Risk of Osmotic Demyelination Syndrome
Severe Hyponatremia in the Emergency Department Incidence of Cerebral Edema and Risk of Osmotic Demyelination Syndrome Open
Study Objective Treatment strategies in severe hyponatremia aim at rapid sodium correction to prevent or treat cerebral edema but limit sodium rise to prevent osmotic demyelination syndrome (ODS). The true risk of edema or ODS in ED patien…
View article: Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model
Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model Open
View article: Safety and effectiveness of oscillatory whole-body vibration training on exercise capacity and physical performance in aortic valve stenosis patients prior to transcatheter aortic valve implantation: a randomized clinical trial
Safety and effectiveness of oscillatory whole-body vibration training on exercise capacity and physical performance in aortic valve stenosis patients prior to transcatheter aortic valve implantation: a randomized clinical trial Open
Background Exercise training is generally discouraged in patients with severe symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) due to safety concerns. However, whole-body vibration (WBV) exercise c…
View article: Disease outcomes following lateral switch among different CD20-antibodies in active multiple sclerosis
Disease outcomes following lateral switch among different CD20-antibodies in active multiple sclerosis Open
Background: Ocrelizumab (OCR) and ofatumumab (OFA)are approved and their differences in dosing route and interval allow personalized treatment. However, there are no data on whether lateral switches between both substances affect treatment…
View article: Pilot Study Identifying Predictive Factors of Diuretic Effectiveness in Emergency Department Patients with Fluid Overload
Pilot Study Identifying Predictive Factors of Diuretic Effectiveness in Emergency Department Patients with Fluid Overload Open
Urine sodium and urine electrical conductivity were associated with diuretic success in this pilot study. As these parameters can be determined prior to treatment initiation, their value as predictive markers should be evaluated in further…
View article: Physical activity and network attack tolerance preserve motor function in Parkinson’s disease: A pilot study
Physical activity and network attack tolerance preserve motor function in Parkinson’s disease: A pilot study Open
We tested whether network resilience, quantified by network attack tolerance (NAT), is associated with dopamine terminal (DaT) integrity, motor function and lifestyle factors in Parkinson’s disease (PD). Data from 22 individuals with PD an…
View article: Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease
Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease Open
Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study …
View article: Overcoming Model Uncertainty — How Equivalence Tests Can Benefit From Model Averaging
Overcoming Model Uncertainty — How Equivalence Tests Can Benefit From Model Averaging Open
A common problem in numerous research areas, particularly in clinical trials, is to test whether the effect of an explanatory variable on an outcome variable is equivalent across different groups. In practice, these tests are frequently us…
View article: Capturing heterogeneous time-variation in covariate effects in non-proportional hazard regression models
Capturing heterogeneous time-variation in covariate effects in non-proportional hazard regression models Open
A central focus in survival analysis is examining how covariates influence survival time. These covariate effects are often found to be either time-varying, heterogeneous - such as being specific to patients, treatments, or subgroups - or …
View article: The Impact of Lesion-Specific and Sampling-Related Factors on Success of Salivary Gland Fine-Needle Aspiration Cytology
The Impact of Lesion-Specific and Sampling-Related Factors on Success of Salivary Gland Fine-Needle Aspiration Cytology Open
Purpose Ultrasound-guided fine-needle aspiration cytology (FNAC) is a widely used diagnostic procedure which facilitates the differentiation of salivary gland lesions. Although the performance of salivary gland FNAC (SG-FNAC) has improved …
View article: Practically Significant Differences between Conditional Distribution Functions
Practically Significant Differences between Conditional Distribution Functions Open
View article: Different Treatment Outcomes of Multiple Sclerosis Patients Receiving Ocrelizumab or Ofatumumab
Different Treatment Outcomes of Multiple Sclerosis Patients Receiving Ocrelizumab or Ofatumumab Open
Objective B‐cell–depletion via CD20 antibodies is a safe and effective treatment for active relapsing multiple sclerosis (RMS). Both ocrelizumab (OCR) and ofatumumab (OFA) have demonstrated efficacy in randomized controlled trials and are …
View article: Success of salivary gland fine-needle aspiration cytology is depending on various lesion- and sampling-related factors
Success of salivary gland fine-needle aspiration cytology is depending on various lesion- and sampling-related factors Open
Purpose. Ultrasound-guided fine-needle aspiration cytology (FNAC) is a widely used diagnostic procedure which facilitates the differentiation of salivary gland lesions. Although the performance of salivary gland FNAC (SG-FNAC) has improved…
View article: Testing Similarity of Parametric Competing Risks Models for Identifying Potentially Similar Pathways in Healthcare
Testing Similarity of Parametric Competing Risks Models for Identifying Potentially Similar Pathways in Healthcare Open
The identification of similar patient pathways is a crucial task in healthcare analytics. A flexible tool to address this issue are parametric competing risks models, where transition intensities may be specified by a variety of parametric…
View article: Telepharmacy versus Face-to-Face Approach in Providing Inhaler Technique Training Service: A Non-Inferiority Assessment Among German Pharmacy Students
Telepharmacy versus Face-to-Face Approach in Providing Inhaler Technique Training Service: A Non-Inferiority Assessment Among German Pharmacy Students Open
Considering our findings, telepharmacy is a viable alternative to traditional face-to-face consultations for providing inhaler technique training service. However, to address perceived difficulties and differences between virtual and face-…
View article: Identification of changes in gene expression
Identification of changes in gene expression Open
Evaluating the change in gene expression is a common goal in many research areas, such as in toxicological studies as well as in clinical trials. In practice, the analysis is often based on multiple t-tests evaluated at the observed time p…
View article: A nonparametric proportional risk model to assess a treatment effect in time‐to‐event data
A nonparametric proportional risk model to assess a treatment effect in time‐to‐event data Open
Time‐to‐event analysis often relies on prior parametric assumptions, or, if a semiparametric approach is chosen, Cox's model. This is inherently tied to the assumption of proportional hazards, with the analysis potentially invalidated if t…
View article: Overcoming model uncertainty -- how equivalence tests can benefit from model averaging
Overcoming model uncertainty -- how equivalence tests can benefit from model averaging Open
A common problem in numerous research areas, particularly in clinical trials, is to test whether the effect of an explanatory variable on an outcome variable is equivalent across different groups. In practice, these tests are frequently us…
View article: A nonparametric relative treatment effect for direct comparisons of censored paired survival outcomes
A nonparametric relative treatment effect for direct comparisons of censored paired survival outcomes Open
A frequently addressed issue in clinical trials is the comparison of censored paired survival outcomes, for example, when individuals were matched based on their characteristics prior to the analysis. In this regard, a proper incorporation…
View article: Testing for similarity of multivariate mixed outcomes using generalised joint regression models with application to efficacy-toxicity responses
Testing for similarity of multivariate mixed outcomes using generalised joint regression models with application to efficacy-toxicity responses Open
A common problem in clinical trials is to test whether the effect of an explanatory variable on a response of interest is similar between two groups, e.g. patient or treatment groups. In this regard, similarity is defined as equivalence up…
View article: Testing similarity of parametric competing risks models for identifying potentially similar pathways in healthcare
Testing similarity of parametric competing risks models for identifying potentially similar pathways in healthcare Open
The identification of similar patient pathways is a crucial task in healthcare analytics. A flexible tool to address this issue are parametric competing risks models, where transition intensities may be specified by a variety of parametric…
View article: Dynamic Heterogeneity in Discrete Choice Experiments
Dynamic Heterogeneity in Discrete Choice Experiments Open
View article: Wearable based monitoring and self-supervised contrastive learning detect clinical complications during treatment of Hematologic malignancies
Wearable based monitoring and self-supervised contrastive learning detect clinical complications during treatment of Hematologic malignancies Open
View article: Sodium evolution in hyponatraemia: a mixed effects model analysis of the Hyponatraemia Registry
Sodium evolution in hyponatraemia: a mixed effects model analysis of the Hyponatraemia Registry Open
Objective Achieving recommended targets of sodium correction is challenging to physicians treating hyponatraemia. Plasma sodium has to be increased effectively, yet overcorrection must be prevented. This is often hampered by a high variabi…
View article: A non-parametric proportional risk model to assess a treatment effect in time-to-event data
A non-parametric proportional risk model to assess a treatment effect in time-to-event data Open
Time-to-event analysis often relies on prior parametric assumptions, or, if a non-parametric approach is chosen, Cox's model. This is inherently tied to the assumption of proportional hazards, with the analysis potentially invalidated if t…
View article: Comparing regression curves -- an $L^1$-point of view
Comparing regression curves -- an $L^1$-point of view Open
In this paper we compare two regression curves by measuring their difference by the area between the two curves, represented by their $L^1$-distance. We develop asymptotic confidence intervals for this measure and statistical tests to inve…
View article: Investigating non-inferiority or equivalence in time-to-event data under non-proportional hazards
Investigating non-inferiority or equivalence in time-to-event data under non-proportional hazards Open
The classical approach to analyze time-to-event data, e.g. in clinical trials, is to fit Kaplan–Meier curves yielding the treatment effect as the hazard ratio between treatment groups. Afterwards, a log-rank test is commonly performed to i…
View article: Selective Internal Radiotherapy in Germany: a review of indications and hospital mortality from 2012 to 2019
Selective Internal Radiotherapy in Germany: a review of indications and hospital mortality from 2012 to 2019 Open
SIRT is a safe procedure with very low overall mortality and a well-definable spectrum of adverse events, particularly gastrointestinal. Complications are usually treatable or self-limiting. Acute liver failure is a potentially fatal but e…
View article: Identifying Alert Concentrations Using a Model-Based Bootstrap Approach
Identifying Alert Concentrations Using a Model-Based Bootstrap Approach Open
The determination of alert concentrations, where a pre-specified threshold of the response variable is exceeded, is an important goal of concentration–response studies. The traditional approach is based on investigating the measured concen…
View article: Current Developments of Selective Internal Radiotherapy (SIRT) in Germany: A Systematic Analysis of Indication and Hospital Mortality between 2012 and 2019
Current Developments of Selective Internal Radiotherapy (SIRT) in Germany: A Systematic Analysis of Indication and Hospital Mortality between 2012 and 2019 Open
Background Selective Internal Radiotherapy (SIRT) is a minimal invasive tumor therapy for hepatocellular carcinoma (HCC), biliary tract cancer (BTC), and liver metastasis of extrahepatic tumors. Comprehensive data on past and current trend…