Kathrin Stelzner
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View article: <i>Chlamydia trachomatis</i> subverts neutrophil cell death pathways through RIP3 and Mcl-1 manipulation
<i>Chlamydia trachomatis</i> subverts neutrophil cell death pathways through RIP3 and Mcl-1 manipulation Open
Chlamydia trachomatis , an obligate intracellular pathogen, manipulates host cells to evade immune detection, contributing to sexually transmitted diseases with severe complications. Neutrophils, short-lived effector cells, form the first …
View article: Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages
Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages Open
Staphylococcus aureus is a notorious human pathogen that thrives in macrophages. It resides in mature phagolysosomes, where a subset of the bacteria eventually begin to proliferate. How S. aureus acquires essential nutrients, such as amino…
View article: <i>Chlamydia trachomatis</i> exploits sphingolipid metabolic pathways during infection of phagocytes
<i>Chlamydia trachomatis</i> exploits sphingolipid metabolic pathways during infection of phagocytes Open
Chlamydiae are obligate intracellular pathogens that utilize host cell metabolites for catabolic and anabolic processes. The bacteria replicate in epithelial cells from which they take up sphingolipids (SL) and incorporate them into the ch…
View article: Infection of human organoids supports an intestinal niche for Chlamydia trachomatis
Infection of human organoids supports an intestinal niche for Chlamydia trachomatis Open
Several reports suggest that intestinal tissue may be a natural niche for Chlamydia trachomatis infection and a reservoir for persistent infections in the human body. Due to the human specificity of the pathogen and the lack of suitable ho…
View article: Infection of human organoids supports an intestinal niche for<i>Chlamydia trachomatis</i>
Infection of human organoids supports an intestinal niche for<i>Chlamydia trachomatis</i> Open
Several reports suggest that intestinal tissue may be a natural niche for Chlamydia trachomatis infection and a reservoir for persistent infections in the human body. Due to the human specificity of the pathogen and the lack of suitable ho…
View article: c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis
c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis Open
Chlamydia trachomatis (Ctr) can persist over extended times within their host cell and thereby establish chronic infections. One of the major inducers of chlamydial persistence is interferon-gamma (IFN-γ) released by immune cells as a mech…
View article: Author response: c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis
Author response: c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Chlamydia trachomatis …
View article: Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells
Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells Open
Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Uptake by host cells is thought to contribute to pathogenicity and persistence of the bacterium. Upon internaliz…
View article: Intracellular Staphylococcus aureus Perturbs the Host Cell Ca <sup>2+</sup> Homeostasis To Promote Cell Death
Intracellular Staphylococcus aureus Perturbs the Host Cell Ca <sup>2+</sup> Homeostasis To Promote Cell Death Open
Despite being regarded as an extracellular bacterium, the pathogen Staphylococcus aureus can invade and survive within human cells. The intracellular niche is considered a hideout from the host immune system and antibiotic treatment and al…
View article: Intracellular<i>Staphylococcus aureus</i>perturbs the host cell Ca<sup>2+</sup>-homeostasis to promote cell death
Intracellular<i>Staphylococcus aureus</i>perturbs the host cell Ca<sup>2+</sup>-homeostasis to promote cell death Open
The opportunistic human pathogen Staphylococcus aureus causes serious infectious diseases ranging from superficial skin and soft tissue infections to necrotizing pneumonia and sepsis. While classically regarded as extracellular pathogen, S…
View article: Intracellular<i>Staphylococcus aureus</i>employs the cysteine protease staphopain A to induce host cell death in epithelial cells
Intracellular<i>Staphylococcus aureus</i>employs the cysteine protease staphopain A to induce host cell death in epithelial cells Open
Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Intracellularity is thought to contribute to pathogenicity and persistence of the bacterium. Upon internalizatio…