Kathryn Allaway
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View article: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes
An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes Open
SUMMARY In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools to access and manipulate spe…
View article: Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain
Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain Open
The basal forebrain cholinergic system projects broadly throughout the cortex and constitutes a critical source of neuromodulation for arousal and attention. Traditionally, this system was thought to function diffusely. However, recent stu…
View article: Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain
Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain Open
The basal forebrain cholinergic system projects broadly throughout the cortex and constitutes a critical source of neuromodulation for arousal and attention. Traditionally, this system was thought to function diffusely. However, recent stu…
View article: Viral manipulation of functionally distinct neurons from mice to humans
Viral manipulation of functionally distinct neurons from mice to humans Open
Recent success in identifying gene regulatory elements in the context of recombinant adeno-associated virus vectors have enabled cell type-restricted gene expression. However, within the cerebral cortex these tools are presently limited to…
View article: Characterizing the epigenetic landscape of cellular populations from bulk and single-cell ATAC-seq information
Characterizing the epigenetic landscape of cellular populations from bulk and single-cell ATAC-seq information Open
Given its ability to map chromatin accessibility with single base pair resolution, ATAC-seq has become a leading technology to probe the epigenomic landscape of single and aggregated cells. Understanding ATAC-seq data presents distinct ana…
View article: Developmental diversification of cortical inhibitory interneurons
Developmental diversification of cortical inhibitory interneurons Open
Diverse subsets of cortical interneurons play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions, yet our understanding of how this diversity is generated is far from…