Kathryn Barger
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View article: Dietary prevention of antibiotic‐induced dysbiosis and mortality upon aging in mice
Dietary prevention of antibiotic‐induced dysbiosis and mortality upon aging in mice Open
Oral antibiotic use is both widespread and frequent in older adults and has been linked to dysbiosis of the gut microbiota, enteric infection, and chronic diseases. Diet and nutrients, particularly prebiotics, may modify the susceptibility…
View article: ipolygrowth: an R package to calculate individual growth curve parameters from bacterial time series data
ipolygrowth: an R package to calculate individual growth curve parameters from bacterial time series data Open
The ipolygrowth package is a user-friendly tool that calculates growth curve parameters for time series data from microplate readers. Calculations are based on fourth-degree polynomial functions, which provide an alternative to commonly us…
View article: Protocol for the Nutrition for Brain and Body Health Study: A Randomized Feasibility Trial
Protocol for the Nutrition for Brain and Body Health Study: A Randomized Feasibility Trial Open
Older adults with obesity have an increased risk for cognitive decline and subsequent Alzheimer’s disease. Previous research has focused on the impact of individual nutrients and overall dietary patterns to improve cognitive function…
View article: Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study
Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study Open
[This corrects the article DOI: 10.3389/fnut.2023.1230061.].
View article: Effect of Anamorelin, a Ghrelin Receptor Agonist, on Muscle and Bone in Adults With Osteosarcopenia
Effect of Anamorelin, a Ghrelin Receptor Agonist, on Muscle and Bone in Adults With Osteosarcopenia Open
Context Anamorelin, a ghrelin receptor agonist known to stimulate the pulsatile release of GH from the pituitary, has the potential to improve musculoskeletal health in adults with osteosarcopenia. Objective To determine the effect of anam…
View article: USING NETWORK ANALYSIS TO EXPLORE DIFFERENCES IN DIETARY INTAKES ACROSS OLDER ADULTHOOD
USING NETWORK ANALYSIS TO EXPLORE DIFFERENCES IN DIETARY INTAKES ACROSS OLDER ADULTHOOD Open
Federal nutrition guidance in the Unites States (US) is based on the premise that healthy diets can help delay the onset or progression of age-related disease and disability. Yet, little is known about if or how dietary intakes differ acro…
View article: POSTPANDEMIC SUCCESSES AND CHALLENGES IN REOPENING OLDER AMERICANS ACT CONGREGATE MEALS
POSTPANDEMIC SUCCESSES AND CHALLENGES IN REOPENING OLDER AMERICANS ACT CONGREGATE MEALS Open
The COVID-19 pandemic required Older Americans Act (OAA) congregate nutrition programs to shut down in-person dining but continue serving meals in innovative ways. Re-opening provided a unique opportunity for congregate nutrition programs …
View article: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study
Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study Open
Introduction The safety of novel forms of iron in healthy, iron-replete adults as might occur if used in population-based iron supplementation programs was examined. We tested the hypotheses that supplementation with nanoparticulate iron h…
View article: Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Open
Vitamin K status was not consistently associated with CAC or PWV in adults with mild-to-moderate CKD.
View article: Brain vitamin D forms, cognitive decline, and neuropathology in community‐dwelling older adults
Brain vitamin D forms, cognitive decline, and neuropathology in community‐dwelling older adults Open
Introduction Vitamin D purportedly protects against cognitive decline and dementia based on observational data using circulating 25‐hydroxyvitamin D (25(OH)D). Little is known about vitamin D in the human brain and the association with dem…
View article: Association of vitamin K with cognitive decline and neuropathology in community‐dwelling older persons
Association of vitamin K with cognitive decline and neuropathology in community‐dwelling older persons Open
Higher vitamin K intakes have been associated with better cognitive function, suggestive of a vitamin K mechanistic effect or simply reflective of a healthy diet. To test the hypothesis that brain vitamin K is linked to cognitive decline a…
View article: Spillover Effects of a Family-Based Childhood Weight-Management Intervention on Parental Nutrient Biomarkers and Cardiometabolic Risk Factors
Spillover Effects of a Family-Based Childhood Weight-Management Intervention on Parental Nutrient Biomarkers and Cardiometabolic Risk Factors Open
The benefits of a family-based childhood weight-management intervention can spill over to parents, resulting in apparent healthier dietary shifts that are associated with modest improvements in some CMRFs.
View article: Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia
Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia Open
Background: Healthy dietary patterns are related to better cognitive health in aging populations. While levels of individual nutrients in neural tissues are individually associated with cognitive function, the investigation of nutrient pat…
View article: Spillover Effects of a Family-Based Childhood Obesity Intervention on Parental Nutrient Biomarkers and Cardiometabolic Risk Factors
Spillover Effects of a Family-Based Childhood Obesity Intervention on Parental Nutrient Biomarkers and Cardiometabolic Risk Factors Open
OBJECTIVES: To evaluate the impact of a family-based weight management intervention for children with overweight/obesity on parental nutrient biomarker concentrations and cardiometabolic risk factors (CMRF). METHODS: Secondary analysis fro…
View article: Modifying the Gut Microbiome Through Diet or Antibiotics Alters Bone Phenotypes in Older Mice
Modifying the Gut Microbiome Through Diet or Antibiotics Alters Bone Phenotypes in Older Mice Open
OBJECTIVES: Gut microbiota have been shown to influence bone quality and quantity, both risk determinants for osteoporosis. Previous research in young mice showed oral antibiotic treatment during rapid bone gain impaired bone tissue qualit…
View article: Safe and effective delivery of supplemental iron to healthy older adults: The double-blind, randomized, placebo-controlled trial protocol of the Safe Iron Study
Safe and effective delivery of supplemental iron to healthy older adults: The double-blind, randomized, placebo-controlled trial protocol of the Safe Iron Study Open
The forms of iron currently available to correct iron deficiency have adverse effects, including infectious diarrhea, increased susceptibility to malaria, inflammation and detrimental changes to the gut microbiome. These adverse effects li…
View article: Perspective: Design and Conduct of Human Nutrition Randomized Controlled Trials
Perspective: Design and Conduct of Human Nutrition Randomized Controlled Trials Open
In the field of human nutrition, randomized controlled trials (RCTs) are considered the gold standard for establishing causal relations between exposure to nutrients, foods, or dietary patterns and prespecified outcome measures, such as bo…
View article: The Interaction of Gut Microbiota Composition and Dietary Starch Form on Gut Health in Aged Mice
The Interaction of Gut Microbiota Composition and Dietary Starch Form on Gut Health in Aged Mice Open
OBJECTIVES: A high glycemic diet has been shown to increase gut permeability, which is associated with increased disease risk. Our objective was to evaluate the role of gut microbiota in mediating the relationship between dietary starch co…
View article: Ferrous Sulfate-Iron (60 mg/d) Does Not Increase Risks to Malarial Infectivity, Pathogenic Bacterial Proliferation or Other Adverse Effects in Non-Anemic Healthy Adults
Ferrous Sulfate-Iron (60 mg/d) Does Not Increase Risks to Malarial Infectivity, Pathogenic Bacterial Proliferation or Other Adverse Effects in Non-Anemic Healthy Adults Open
OBJECTIVES: A double-blind, placebo-controlled, randomized clinical trial was conducted to determine the effects of different modalities of supplementation with ferrous sulfate (FeSO(4))-iron on the safety profiles of non-anemic, healthy a…
View article: Effect of a Family-Based Intervention on Nutrient Biomarkers, Desaturase Enzyme Activities, and Cardiometabolic Risk Factors in Children with Overweight and Obesity
Effect of a Family-Based Intervention on Nutrient Biomarkers, Desaturase Enzyme Activities, and Cardiometabolic Risk Factors in Children with Overweight and Obesity Open
Providing targeted family-based behavioral counseling, as part of SC, can help overweight/obese children adopt healthier eating patterns that are associated with modest improvements in BMIz and several CMRFs. Limited additional benefit was…
View article: THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS Open
A role for vitamin K in cardiovascular disease (CVD) has been proposed because vitamin K-dependent proteins are present in vascular tissue. We evaluated the association between vitamin K status and incident CVD and mortality in older adult…
View article: Safe and effective delivery of supplemental iron to healthy older adults: The double-blind, randomized, placebo-controlled trial protocol of the Safe Iron Study
Safe and effective delivery of supplemental iron to healthy older adults: The double-blind, randomized, placebo-controlled trial protocol of the Safe Iron Study Open
The forms of iron currently available to correct iron deficiency have adverse effects, including infectious diarrhea, increased susceptibility to malaria, inflammation and detrimental changes to the gut microbiome. These adverse effects li…