Kathryn T. Chen
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View article: Less is More: A Cost and Environmental Waste Analysis in Nonadherence to Antibiotic Prophylaxis Guidelines in Clean Ambulatory Surgical Procedures
Less is More: A Cost and Environmental Waste Analysis in Nonadherence to Antibiotic Prophylaxis Guidelines in Clean Ambulatory Surgical Procedures Open
Background Antibiotic misuse extends beyond clinical outcomes, imposing significant financial, operational, and environmental burdens on health care systems. Despite guidelines advising against antibiotic prophylaxis for elective low-risk …
View article: The Utility of ACR TI-RADS in Predicting False-Negative Fine Needle Aspiration for Thyroid Cancer
The Utility of ACR TI-RADS in Predicting False-Negative Fine Needle Aspiration for Thyroid Cancer Open
Background Thyroid nodule fine needle aspiration (FNA) biopsies are associated with a low false-negative rate. There is limited data regarding the predictive value of American College of Radiology Thyroid Imaging Reporting and Data System …
View article: Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels
Clinical Features and Outcomes of Patients with Pancreaticobiliary Malignancies in Los Angeles County and Their Association with CA 19-9 Levels Open
Although CA 19-9 is a commonly used tumor marker in the management of PBMs, the literature describing outcomes in patients with PBMs who have undetectable or low (hereinafter “low”) CA 19-9 levels remains scarce. In this study, we sought t…
View article: Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials Open
Pancreatic adenocarcinoma (PDAC) originates in the glandular compartment of the exocrine pancreas. Histologically, PDAC tumors are characterized by a parenchyma that is embedded in a particularly prominent stromal component or desmoplastic…
View article: N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells
N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells Open
N-myristoyltransferase-1 (NMT1) catalyzes protein myristoylation, a lipid modification that is elevated in cancer cells. NMT1 sustains proliferation and/or survival of cancer cells through mechanisms that are not completely understood. We …
View article: Advances in Translational Research and Clinical Care in Pancreatic Cancer: Where Are We Headed?
Advances in Translational Research and Clinical Care in Pancreatic Cancer: Where Are We Headed? Open
While significant advances have been made in the treatment of many different solid tumors, pancreatic cancer remains a glaring exception. Overall 5-year survival rates for pancreatic cancer remain in the single digits. While newer chemothe…
View article: Traumatic bile duct neuroma presenting with acute cholangitis: A case report and review of literature
Traumatic bile duct neuroma presenting with acute cholangitis: A case report and review of literature Open
Traumatic neuroma of the biliary tree has been previously reported as isolated case reports. In literature, these typically present following prior liver transplant or cholecystectomy, wherein the bile ducts have been disrupted in some for…
View article: Experimental supporting data on TKS5 and Cortactin expression and localization in human pancreatic cancer cells and tumors
Experimental supporting data on TKS5 and Cortactin expression and localization in human pancreatic cancer cells and tumors Open
In this article, using human pancreatic cancer cell lines and tumor specimens, we analyze the expression and localization of the invadopodia-related proteins TKS5 and Cortactin. Specifically, we present data on: a) TKS5 expression and loca…