Kathryn E. Hamilton
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View article: An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease
An Epigenetic Basis for Sustained Inflammatory Epithelial Progenitor Cell States in Crohn’s Disease Open
We have defined differences in the epithelial stem and progenitor compartment of patients with Crohn's disease that suggest aberrant stem cell differentiation and inflammatory gene expression arise and persist during disease.
View article: Gastric epithelium from <i>BRCA1</i> and <i>BRCA2</i> carriers harbors increased double-stranded DNA damage and augmented growth
Gastric epithelium from <i>BRCA1</i> and <i>BRCA2</i> carriers harbors increased double-stranded DNA damage and augmented growth Open
An accumulating body of evidence suggests carriers of a pathogenic germline variant (PGV) in BRCA1 or BRCA2 have increased gastric cancer (GC) risk. BRCA1 and BRCA2 are tumor suppressor genes involved in promoting homologous recombination …
View article: An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn’s disease
An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn’s disease Open
SUMMARY Defining consequential differences in intestinal epithelial stem cells in healthy humans versus those with inflammatory bowel disease (Crohn’s disease and ulcerative colitis) is essential for the development of much needed therapie…
View article: IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B
IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B Open
BACKGROUND & AIMS: The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue injury and divide t…
View article: Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival
Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival Open
Intestinal epithelial transit-amplifying cells are essential stem progenitors required for intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage from radiation and chemotherapy. Despite these cells' cr…
View article: Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential
Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential Open
Background & Aims Autophagy has been demonstrated to play roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelium under homeostatic conditions. Methods We generated t…
View article: Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival Open
Intestinal epithelial transit amplifying cells are essential stem progenitors required for intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage from radiation and chemotherapy. Despite their critical …
View article: Table S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Table S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
Antibody List
View article: Table S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Table S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
shRNA
View article: Supplementary Figure Legend from Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon
Supplementary Figure Legend from Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon Open
Supp. Fig. 1 legend
View article: Table S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Table S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
shRNA
View article: Table S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Table S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
Antibody List
View article: Supplementary Figure S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Supplementary Figure S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
LIN28B-S in Huh7.5 cells
View article: Data from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Data from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
The RNA-binding protein LIN28B plays an important role in development, stem cell biology, and tumorigenesis. LIN28B has two isoforms: the LIN28B-long and -short isoforms. Although studies have revealed the functions of the LIN28B-long isof…
View article: Supplementary Figure S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Supplementary Figure S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
LIN28B mRNA expression in human CRC samples
View article: Supplementary Figure S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Supplementary Figure S2 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
LIN28B mRNA expression in human CRC samples
View article: Data from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Data from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
The RNA-binding protein LIN28B plays an important role in development, stem cell biology, and tumorigenesis. LIN28B has two isoforms: the LIN28B-long and -short isoforms. Although studies have revealed the functions of the LIN28B-long isof…
View article: Table S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Table S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
qPCR primers
View article: Supplementary Figure 1 from Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon
Supplementary Figure 1 from Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon Open
Supplementary Figure 1. Dermo1Cre;Rosa-CAG-LSL-TdTomato mice.
View article: Supplementary Figure S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Supplementary Figure S3 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
LIN28B-S in Huh7.5 cells
View article: Supplementary Figure S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Supplementary Figure S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
LIN28B short isoform in Huh7.5 cell
View article: Supplementary Figure S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Supplementary Figure S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
LIN28B short isoform in Huh7.5 cell
View article: Table S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions
Table S1 from Differential Regulation of <i>LET-7</i> by LIN28B Isoform–Specific Functions Open
qPCR primers
View article: Supplemental Methods from Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors
Supplemental Methods from Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors Open
Supplemental Methods from Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors
View article: Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis
Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis Open
Background & Aims Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is upregulated i…
View article: Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction
Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction Open
Calorie restriction is associated with enhanced intestinal regeneration after irradiation, but the requirement of autophagy for this process is not known. Our data support the premise that intestinal epithelial autophagy is required for th…
View article: High autophagic vesicle content marks facultative stem cells of the gut
High autophagic vesicle content marks facultative stem cells of the gut Open
Understanding how macroautophagy/autophagy contributes to tissue homeostasis is essential for understanding organismal health. The intestinal epithelium is an ideal model to define mechanisms that regulate tissue homeostasis because it hou…