Kathryn White
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View article: Variation in patterns of production and water-use efficiency among agroecosystems
Variation in patterns of production and water-use efficiency among agroecosystems Open
Across agroecosystems, water is a key driver of primary production, and the relationship between precipitation and production (i.e., water-use efficiency; WUE) provides an important indicator for evaluating agroecosystem resilience to chan…
View article: 3D Neuronal Mitochondrial Morphology in Axons, Dendrites, and Somata of the Aging Mouse Hippocampus
3D Neuronal Mitochondrial Morphology in Axons, Dendrites, and Somata of the Aging Mouse Hippocampus Open
Summary The brain’s ability to process complex informations relies on the constant supply of energy through aerobic respiration by mitochondria. Neurons contain three anatomically distinct compartments – the soma, dendrites, and projecting…
View article: Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas
Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas Open
The pancreas is particularly sensitive to acute cellular stress, but this has been difficult to evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ donation negatively impacts whole‐organ and isolated‐islet…
View article: Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function Open
Age-related macular degeneration (AMD) is a multifactorial disease, which is characterized by loss of central vision, affecting one in three people by the age of 75. The Y402H polymorphism in the complement factor H (CFH) gene significantl…
View article: Mitochondrial morphology and function: two for the price of one!
Mitochondrial morphology and function: two for the price of one! Open
Summary Mitochondrial shape and function are known to be linked; therefore, there is a need to combine three‐dimensional EM structural analysis with functional analysis. Cytochrome c oxidase labelling is one approach to examine mitochondri…
View article: Erratum. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. Diabetes 2019;68:
Erratum. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. Diabetes 2019;68: Open
In the article cited above, funding was mistakenly omitted for author Xiaoyan Bai. The following statement has been added to correct this: …
View article: Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature
Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature Open
Damage to the vasculature is the primary mechanism driving chronic diabetic microvascular complications such as diabetic nephropathy, which manifests as albuminuria. Therefore, treatments that protect the diabetic vasculature have signific…
View article: Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network Open
(Cell Reports 26, 996–1009.e1–e4; January 22, 2019) In the version of this article originally published online, there was a misspelling of the name Conor Lawless in the author list. This has now been corrected online. The authors apologize…
View article: Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences
Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences Open
A major goal in the stem cell field is to generate tissues that can be utilized as a universal tool for in vitro models of development and disease, drug development, or as a resource for patients suffering from disease or injury. Great eff…
View article: Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids Open
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation. To mimic this phenomenon in vitro, tis…
View article: An integrated transcriptional analysis of the developing human retina
An integrated transcriptional analysis of the developing human retina Open
The scarcity of embryonic/foetal material as a resource for direct study means that there is still limited understanding of human retina development. Here, we present an integrated transcriptome analysis combined with immunohistochemistry …
View article: Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network Open
Genetic and biochemical defects of mitochondrial function are a major cause of human disease, but their link to mitochondrial morphology in situ has not been defined. Here, we develop a quantitative three-dimensional approach to map mitoch…
View article: Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury
Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury Open
Planar cell polarity (PCP) pathways control the orientation and alignment of epithelial cells within tissues. Van Gogh‐like 2 (Vangl2) is a key PCP protein that is required for the normal differentiation of kidney glomeruli and tubules. Va…
View article: Subcellular origin of mitochondrial DNA deletions in human skeletal muscle
Subcellular origin of mitochondrial DNA deletions in human skeletal muscle Open
Objective In patients with mitochondrial DNA (mtDNA) maintenance disorders and with aging, mtDNA deletions sporadically form and clonally expand within individual muscle fibers, causing respiratory chain deficiency. This study aimed to ide…
View article: A guide to analysis and reconstruction of serial block face scanning electron microscopy data
A guide to analysis and reconstruction of serial block face scanning electron microscopy data Open
Summary Serial block face scanning electron microscopy (SBF‐SEM) is a relatively new technique that allows the acquisition of serially sectioned, imaged and digitally aligned ultrastructural data. There is a wealth of information that can …
View article: Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa
Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa Open
Summary Mutations in pre-mRNA processing factors (PRPFs) cause 40% of autosomal dominant retinitis pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed PRPFs cause retinal disease. To understand the molecular basis of…
View article: Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease
Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease Open
Histone protein modifications control fate determination during normal development and dedifferentiation during disease. Here, we set out to determine the extent to which dynamic changes to histones affect the differentiated phenotype of o…
View article: A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies
A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies Open
Joubert syndrome (JBTS) is the archetypal ciliopathy caused by mutation of genes encoding ciliary proteins leading to multi-system phenotypes, including a cerebello-retinal-renal syndrome. JBTS is genetically heterogeneous, however mutatio…
View article: A Guide to Analysis and Reconstruction of Serial Block Face Scanning Electron Microscopy Data
A Guide to Analysis and Reconstruction of Serial Block Face Scanning Electron Microscopy Data Open
Serial block face scanning electron microscopy (SBF-SEM) is a relatively new technique that allows the acquisition of serially sectioned, imaged and digitally aligned ultrastructural data. There is a wealth of information that can be obtai…
View article: 166 Changes in e-c coupling proteins and transverse and axial tubular structures in guinea pig ventricular muscle during pre- and post-natal development to adulthood
166 Changes in e-c coupling proteins and transverse and axial tubular structures in guinea pig ventricular muscle during pre- and post-natal development to adulthood Open
Transverse tubules (TT), plasmalemma invaginations perpendicular to the long axis of the cardiomyocyte, facilitate rapid action potential transmission to the cell interior and efficient cardiac excitation-contraction coupling (ECC). Tubule…