Kathryn Franke
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View article: Clinically‐relevant proteomic and metabolomic signatures with effective neuroprotective treatment of the Tg4344AD rat model of Alzheimer's disease
Clinically‐relevant proteomic and metabolomic signatures with effective neuroprotective treatment of the Tg4344AD rat model of Alzheimer's disease Open
Background Alzheimer's disease (AD) is a progressive brain disorder that severely impairs behavior and cognitive functions. This includes depression, which often appears earlier than cognitive impairment. This study reports early‐stage pro…
View article: You have no power here! Social status does not modulate observationally acquired binding and retrieval effects
You have no power here! Social status does not modulate observationally acquired binding and retrieval effects Open
Previous research shows that observationally acquired stimulus-response binding and retrieval (oSRBR) effects only occur when the observed person is socially relevant. An important factor that influences one’s social relevance in everyday …
View article: Astrocytic abnormalities in brain-specific <i>Cacna1c</i> -deficient mice: Implications for BBB impairment in neuropsychiatric diseases associated with <i>CACNA1C</i> mutations
Astrocytic abnormalities in brain-specific <i>Cacna1c</i> -deficient mice: Implications for BBB impairment in neuropsychiatric diseases associated with <i>CACNA1C</i> mutations Open
Intronic genetic variants within the CACNA1C gene, which encodes the pore-forming alpha 1c subunit of the Cav1.2 L-type calcium channel, are significant risk factors for a multitude of neuropsychiatric disorders. In most cases, these intro…
View article: Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury
Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury Open
Alzheimer’s disease (AD) and traumatic brain injury (TBI) are currently untreatable neurodegenerative disorders afflicting millions of people worldwide. These conditions are pathologically related, and TBI is one of the greatest risk facto…
View article: No Matter of Trust: Retrieval of Observationally Acquired Stimulus-response Bindings Occurs in Interactions With Both Trustworthy and Untrustworthy Partners
No Matter of Trust: Retrieval of Observationally Acquired Stimulus-response Bindings Occurs in Interactions With Both Trustworthy and Untrustworthy Partners Open
Recent findings show that simply observing how another person responds to a stimulus is sufficient to create stimulus-response (SR) episodes, which can later be retrieved from memory to guide one’s own actions. However, this only occurs if…
View article: Reducing tau acetylation rescues cognitive deficits in a mouse model of traumatic brain injury‐induced acceleration of Alzheimer’s disease
Reducing tau acetylation rescues cognitive deficits in a mouse model of traumatic brain injury‐induced acceleration of Alzheimer’s disease Open
Background TBI is the 3rd greatest risk factor for developing AD, behind genetics and aging. TBI is associated with a 3‐4 year earlier onset of cognitive impairment, and increased cortical thinning and amyloid plaques in people with AD. Th…
View article: Proteomic characterization of the TgF344 AD rat model of Alzheimer’s disease as a function of disease and therapeutic treatment
Proteomic characterization of the TgF344 AD rat model of Alzheimer’s disease as a function of disease and therapeutic treatment Open
Background Alzheimer’s disease (AD) is a severe neurodegenerative condition that affects millions of people worldwide. The TgF344 AD rat model, which exhibits early depression‐like behavior followed by later cognitive impairment, is widely…
View article: Deterioration of neuronal primary cilia in Alzheimer’s disease
Deterioration of neuronal primary cilia in Alzheimer’s disease Open
Background Emerging evidence links Alzheimer’s disease (AD) to dysfunction of the primary cilium, a historically overlooked organelle that serves as the neuron’s antenna. All neurons harbor a single primary cilium that projects from the me…
View article: Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury
Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury Open
Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurod…
View article: MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations
MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations Open
Our genome is exposed to a wide variety of DNA-damaging agents. If left unrepaired, this damage can be converted into mutations that promote carcinogenesis or the development of genetically inherited diseases. As a result, researchers and …
View article: MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations
MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations Open
Our genome is exposed to a wide variety of DNA-damaging agents. If left unrepaired, this damage can be fixed into mutations that promote carcinogenesis and the development of genetically inherited diseases. As a result, it is crucial that …
View article: P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition
P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition Open
Significance Chronic neurodegeneration, a major cause of the long-term disabilities that afflict survivors of traumatic brain injury (TBI), is linked to an increased risk for late-life neurodegenerative disorders, including Alzheimer’s dis…