Kathryn P. Trogden
YOU?
Author Swipe
View article: Author response: Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots
Author response: Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Heterogeneity of gluco…
View article: TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics
TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics Open
Microtubules are regulated by a diverse set of proteins that localize to microtubule plus ends (+TIPs) where they regulate dynamic instability and mediate interactions with the cell cortex, actin filaments, and organelles. Although individ…
View article: Microtubules regulate pancreatic beta cell heterogeneity via spatiotemporal control of insulin secretion hot spots
Microtubules regulate pancreatic beta cell heterogeneity via spatiotemporal control of insulin secretion hot spots Open
Heterogeneity of glucose-stimulated insulin secretion (GSIS) in pancreatic islets is physiologically important but poorly understood. Here, we utilize whole mouse islets to determine how microtubules affect secretion toward the vascular ex…
View article: Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation
Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation Open
Neural tube defects including spina bifida are common and severe congenital disorders. In mice, mutations in more than 200 genes can result in neural tube defects. We hypothesized that this large gene set might include genes whose homologs…
View article: Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells
Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells Open
View article: An image‐based small‐molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells
An image‐based small‐molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells Open
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial‐mesenchymal transition. The goal of this study was to identify vimentin‐targeting small molecules by usi…
View article: The Vanderbilt Postdoctoral Association
The Vanderbilt Postdoctoral Association Open
View article: Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and<i>Caenorhabditis elegans</i>Gastrulation
Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and<i>Caenorhabditis elegans</i>Gastrulation Open
Neural tube defects including spina bifida are common and severe congenital disorders. In mice, mutations in more than 200 genes can result in neural tube defects. We hypothesized that this large gene set might include genes whose homologs…
View article: TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics
TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics Open
Within a cell, the ends of individual microtubules switch between three different phases: growth, shrinkage and pause without affecting the total mass of microtubule polymer. This inherent property of microtubules is termed dynamic instabi…