Kathryn Post
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Author Swipe
View article: Experiences and Preferences of Young Adult Patients With Cancer and Their Romantic Partner Caregivers: A Qualitative Study
Experiences and Preferences of Young Adult Patients With Cancer and Their Romantic Partner Caregivers: A Qualitative Study Open
Background Young adults (YA, ages 25–39) with cancer and their romantic partners experience unique and distressing physical effects and psychological outcomes. While several interventions for YAs exist, few incorporate partner caregivers i…
View article: Effects of Adjuvant Endocrine Therapy–Specific Perceptions on Response to a Behavioral Intervention for Adjuvant Endocrine Therapy Adherence in Patients With Breast Cancer
Effects of Adjuvant Endocrine Therapy–Specific Perceptions on Response to a Behavioral Intervention for Adjuvant Endocrine Therapy Adherence in Patients With Breast Cancer Open
PURPOSE Adjuvant endocrine therapy (AET) is a life-saving medication for patients with hormone-sensitive breast cancer, yet many struggle with adherence, warranting behavioral intervention. In our recent trial, participation in a group cog…
View article: Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer Open
PURPOSE In patients with lung cancer, dyspnea is one of the most prevalent and disabling symptoms, for which effective treatments are lacking. We examined the efficacy of a nurse-led brief behavioral intervention to improve dyspnea in pati…
View article: Stepped Palliative Care for Patients With Advanced Lung Cancer
Stepped Palliative Care for Patients With Advanced Lung Cancer Open
Importance Despite the evidence for early palliative care improving outcomes, it has not been widely implemented in part due to palliative care workforce limitations. Objective To evaluate a stepped-care model to deliver less resource-inte…
View article: Therapeutic Role of Tamoxifen for Triple-Negative Breast Cancer: Leveraging the Interaction Between ERβ and Mutant p53
Therapeutic Role of Tamoxifen for Triple-Negative Breast Cancer: Leveraging the Interaction Between ERβ and Mutant p53 Open
The absence of effective therapeutic targets and aggressive nature of triple-negative breast cancer (TNBC) renders this disease subset difficult to treat. Although estrogen receptor beta (ERβ) is expressed in TNBC, studies on its functiona…
View article: Understanding pain related to adjuvant endocrine therapy after breast cancer: A qualitative report
Understanding pain related to adjuvant endocrine therapy after breast cancer: A qualitative report Open
Patients' experiences varied by patient attributes and revealed modifiable factors that may be targeted through behavioural interventions. AET-related pain is a complex side effect for which psychosocial support may be beneficial.
View article: A telehealth intervention for symptom management, distress, and adherence to adjuvant endocrine therapy: A randomized controlled trial
A telehealth intervention for symptom management, distress, and adherence to adjuvant endocrine therapy: A randomized controlled trial Open
Background Patients taking adjuvant endocrine therapy (AET) after breast cancer face adherence challenges and symptom‐related distress. We conducted a randomized trial to evaluate the feasibility, acceptability, and preliminary efficacy of…
View article: Health-Related Quality of Life and Depression Symptoms in a Cross Section of Patients with Advanced Lung Cancer before and during the COVID-19 Pandemic
Health-Related Quality of Life and Depression Symptoms in a Cross Section of Patients with Advanced Lung Cancer before and during the COVID-19 Pandemic Open
Background: Adults with advanced lung cancer experience reduced health-related quality of life (HRQOL) and psychological symptoms at diagnosis. Objective: This study aimed to evaluate whether the COVID-19 pandemic worsened HRQOL among pati…
View article: Study protocol for a randomised trial evaluating the non-inferiority of stepped palliative care versus early integrated palliative care for patients with advanced lung cancer
Study protocol for a randomised trial evaluating the non-inferiority of stepped palliative care versus early integrated palliative care for patients with advanced lung cancer Open
Introduction Integrating palliative care (PC) early in the illness course for patients with serious cancers improves their outcomes and is recommended by national organisations such as the American Society of Clinical Oncology. However, mo…
View article: Sentinel interaction mapping – a generic approach for the functional analysis of human disease gene variants using yeast
Sentinel interaction mapping – a generic approach for the functional analysis of human disease gene variants using yeast Open
Advances in sequencing technology have led to an explosion in the number of known genetic variants of human genes. A major challenge is to now determine which of these variants contribute to diseases as a result of their effect on gene fun…
View article: Sentinel Interaction Mapping (SIM) – A generic approach for the functional analysis of human disease gene variants using yeast
Sentinel Interaction Mapping (SIM) – A generic approach for the functional analysis of human disease gene variants using yeast Open
Advances in sequencing technology have led to an explosion in the number of known genetic variants of human genes. A major challenge is to now determine which of these variants contribute to diseases as a result of their effect on gene fun…
View article: RESULTS FROM RESEARCH ON A HEALTH-COACHED WALKING PROGRAM IN FAMILY CAREGIVERS OF PERSONS WITH DEMENTIA
RESULTS FROM RESEARCH ON A HEALTH-COACHED WALKING PROGRAM IN FAMILY CAREGIVERS OF PERSONS WITH DEMENTIA Open
Caregivers of persons with dementia demonstrate increased levels of stress, anxiety and depression, placing them at increased risk for poor health-related outcomes. Walking is widely supported as a cost-effective, accessible exercise and w…
View article: Multi-model functionalization of disease-associated <i>PTEN</i> missense mutations identifies multiple molecular mechanisms underlying protein dysfunction
Multi-model functionalization of disease-associated <i>PTEN</i> missense mutations identifies multiple molecular mechanisms underlying protein dysfunction Open
Functional variomics provides the foundation for personalized medicine by linking genetic variation to disease expression, outcome and treatment, yet its utility is dependent on appropriate assays to evaluate mutation impact on protein fun…
View article: Understanding patient engagement in breast cancer survivorship care: A national web-based survey.
Understanding patient engagement in breast cancer survivorship care: A national web-based survey. Open
223 Background: Little is known about patient engagement (PE) into survivorship care (SC). Information is needed to further explore PE into SC, what factors may contribute to it and which patients are more likely to engage in SC and thus b…
View article: Impact of Autism Spectrum Disorder associated PTEN point mutations on protein function and stability
Impact of Autism Spectrum Disorder associated PTEN point mutations on protein function and stability Open
ASD is a prevalent neurodevelopmental disorder characterized by social impairments and repetitive behaviors. Repeated studies indicate a role of genetics in the etiology of the disorder. In the search for genetic causes, whole exome sequen…
View article: Cluster Analysis Demonstrates the Need to Individualize Care for Cancer Survivors
Cluster Analysis Demonstrates the Need to Individualize Care for Cancer Survivors Open
Background In efforts to inform clinical screening and development of survivorship care services, we sought to characterize patterns of health care needs among cancer survivors by (a) identifying and characterizing subgroups based on self-…
View article: Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Open
Our findings identify Syt1 as a novel Ca(2+)-sensitive PS1 modulator that could regulate synaptic Aβ, opening avenues for novel and selective synapse targeting therapeutic strategies.
View article: Additional file 7: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Additional file 7: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Open
Supporting data values. The file presents individual values recorded in the experiments where nâ
View article: Additional file 2: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Additional file 2: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Open
Proteins identified in mass spectrometry screen of mouse brain lysates for novel PS1 calcium-dependent interactors. Synaptotagmin 1 (Syt1) was detected in high calcium condition (calcium +) when GST-PS1 L6-7 and GST-PS1 NT recombinant pept…