Qi Liu
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View article: Mechanism of cancer-associated fibroblast-driven thyroid cancer dedifferentiation via the ZFP57-PKM2 axis-mediated lactate secretion and therapeutic intervention with Resveratrol
Mechanism of cancer-associated fibroblast-driven thyroid cancer dedifferentiation via the ZFP57-PKM2 axis-mediated lactate secretion and therapeutic intervention with Resveratrol Open
Papillary thyroid carcinoma (PTC) undergoes dedifferentiation into aggressive poorly differentiated (PDTC) or anaplastic (ATC) carcinomas in 10–15% of cases, a process potentially driven by cancer-associated fibroblasts (CAFs) within the t…
View article: Neuroendoscopic cystectomy through the posterior approach to the sigmoid sinus for intracranial epidermoid cysts: A review of two cases
Neuroendoscopic cystectomy through the posterior approach to the sigmoid sinus for intracranial epidermoid cysts: A review of two cases Open
Background: Intracranial epidermoid cysts are rare benign intracranial tumors originating from ectodermal tissues originating from ectopic embryonic remnants that can occur in any part of the cranium but are most common in the pontine cere…
View article: The role of cell junctions in radiation-induced injury to normal tissue
The role of cell junctions in radiation-induced injury to normal tissue Open
View article: Alterations of the gut commensal <i>Akkermansia muciniphila</i> in patients with COVID-19
Alterations of the gut commensal <i>Akkermansia muciniphila</i> in patients with COVID-19 Open
Dysbiosis of gut microbiota is well established in coronavirus disease 2019 (COVID-19). While studies have attempted to establish a link between the gut commensal Akkermansia muciniphila (A. muciniphila) and COVID-19, the fin…
View article: Comparative genomics uncovers evolutionary drivers of locust migratory adaptation
Comparative genomics uncovers evolutionary drivers of locust migratory adaptation Open
The findings suggest that the evolution of migratory behavior is associated with increased selective pressure on metabolism and mitochondria-related pathways. Hundreds of genes undergo selective changes during repetitive transitions to mig…
View article: Diabetes-associated MYT1 and MYT3 regulate human β-cell insulin secretion and survival via other diabetes-risk genes
Diabetes-associated MYT1 and MYT3 regulate human β-cell insulin secretion and survival via other diabetes-risk genes Open
Genetic and environmental factors together cause islet β-cell failure, leading to Type 2 diabetes (T2D). Yet how they integrate to regulate β-cells remains largely unclear. Here, we examined how two members of the Myelin transcription fact…
View article: Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease
Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease Open
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions and not others remains unclear. We use a TNF–overexpressing Crohn′s disease (CD) model (Tnf ΔARE/+ ), which typicall…
View article: Safety and efficacy assessment of an mRNA rabies vaccine in dogs, rodents, and cynomolgus macaques
Safety and efficacy assessment of an mRNA rabies vaccine in dogs, rodents, and cynomolgus macaques Open
Rabies is a lethal disease caused by the rabies virus (RABV), which causes acute neurological infections in mammals, including human beings. We previously reported that an mRNA vaccine (LVRNA001) encoding the rabies virus’s glycoprotein in…
View article: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer Open
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, ∼12% of all cases, are uniquely dependent on POU2F3 itsel…
View article: The whole genome dataset of Ichthyscopus pollicaris
The whole genome dataset of Ichthyscopus pollicaris Open
The classification of the Uranoscopidae species is controversial and the Ichthyscopus pollicaris belonging to Uranoscopidae was first reported in 2019. In the present study, the whole genome sequence of I. pollicaris w…
View article: Interaction of the tumor suppressor <scp>SMAD4</scp> and <scp>WNT</scp> signaling in progression to oral squamous cell carcinoma
Interaction of the tumor suppressor <span>SMAD4</span> and <span>WNT</span> signaling in progression to oral squamous cell carcinoma Open
SMAD4 is a tumor suppressor mutated or silenced in multiple cancers, including oral cavity squamous cell carcinoma (OSCC). Human clinical samples and cell lines, mouse models and organoid culture were used to investigate the role that SMAD…
View article: A comprehensive genome survey study unveils the genomic characteristics and phylogenetic evolution of fishes in the Uranoscopidae family
A comprehensive genome survey study unveils the genomic characteristics and phylogenetic evolution of fishes in the Uranoscopidae family Open
The construction of high-quality genomes is fundamental for molecular studies of species. Currently, there are no published genome sequences within the Uranoscopidae family, and research on the genomic characteristics of this family is lac…
View article: Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells
Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells Open
Acute kidney injury (AKI) is a disease characterised by acute onset, high mortality, and poor prognosis, and is mainly caused by ischemia-reperfusion (I/R). Human urine-derived stem cells (USCs) exhibit antioxidant, anti-inflammatory, and …
View article: Super-Enhancer Dysregulation in Rhabdoid Tumor Cells Is Regulated by the SWI/SNF ATPase BRG1
Super-Enhancer Dysregulation in Rhabdoid Tumor Cells Is Regulated by the SWI/SNF ATPase BRG1 Open
Mutations in the SWI/SNF chromatin remodeling complex occur in ~20% of cancers. In rhabdoid tumors defined by loss of the SWI/SNF subunit SMARCB1, dysregulation of enhancer-mediated gene expression is pivotal in driving oncogenesis. Enhanc…
View article: Kaempferol Alleviates Corneal Transplantation Rejection by Inhibiting NLRP3 Inflammasome Activation and Macrophage M1 Polarization via Promoting Autophagy
Kaempferol Alleviates Corneal Transplantation Rejection by Inhibiting NLRP3 Inflammasome Activation and Macrophage M1 Polarization via Promoting Autophagy Open
Corneal transplantation rejection remains a major threat to the success rate in high-risk patients. Given the many side effects presented by traditional immunosuppressants, there is an urgency to clarify the mechanism of corneal transplant…
View article: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer Open
Small cell lung cancers (SCLC) are comprised of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLC, ∼12% of all cases, are uniquely dependent on POU2F3 itself…
View article: A Study of Social Environmental Support and Turnover Intention among Rural Primary School Teachers in China
A Study of Social Environmental Support and Turnover Intention among Rural Primary School Teachers in China Open
The quality of education in rural areas is negatively impacted by teacher attrition. An in-depth study of the issue of rural teacher turnover intention is of great significance to the promotion of educational equity. The main research obje…
View article: Umbilical cord blood-derived neutrophils possess higher viability than peripheral blood derived neutrophils
Umbilical cord blood-derived neutrophils possess higher viability than peripheral blood derived neutrophils Open
Neutrophils, a primary type of immune cell, play critical roles in numerous biological processes. Both umbilical cord blood (UCB) and peripheral blood are rich in neutrophils. UCB is more abundant than peripheral blood, with cells generall…
View article: Alleviating tiling effect by random walk sliding window in high-resolution histological whole slide image synthesis.
Alleviating tiling effect by random walk sliding window in high-resolution histological whole slide image synthesis. Open
Multiplex immunofluorescence (MxIF) is an advanced molecular imaging technique that can simultaneously provide biologists with multiple (i.e., more than 20) molecular markers on a single histological tissue section. Unfortunately, due to i…
View article: Corrigendum: Targeting innate immunity in breast cancer therapy: a narrative review
Corrigendum: Targeting innate immunity in breast cancer therapy: a narrative review Open
[This corrects the article DOI: 10.3389/fimmu.2021.771201.].
View article: Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk
Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk Open
SUMMARY Dendritic cells are essential for establishing thymic central tolerance; however, mechanisms supporting their homeostasis and activation remain unresolved. Through single-cell transcriptomics and functional assays, we identify seve…
View article: Probable digenic inheritance of <scp>Diamond–Blackfan</scp> anemia
Probable digenic inheritance of <span>Diamond–Blackfan</span> anemia Open
A 26‐year‐old female proband with a clinical diagnosis and consistent phenotype of Diamond–Blackfan anemia (DBA, OMIM 105650) without an identified genotype was referred to the Undiagnosed Diseases Network. DBA is classically associated wi…
View article: <i>Ustilaginoidea virens</i>‐secreted effector Uv1809 suppresses rice immunity by enhancing <scp>O</scp>s<scp>SRT</scp>2‐mediated histone deacetylation
<i>Ustilaginoidea virens</i>‐secreted effector Uv1809 suppresses rice immunity by enhancing <span>O</span>s<span>SRT</span>2‐mediated histone deacetylation Open
Summary Rice false smut caused by Ustilaginoidea virens is a devastating rice ( Oryza sativa) disease worldwide. However, the molecular mechanisms underlying U . virens –rice interactions are largely unknown. In this study, we identified a…
View article: Clinical and cellular phenotypes resulting from a founder mutation in <i>IL10RB</i>
Clinical and cellular phenotypes resulting from a founder mutation in <i>IL10RB</i> Open
Inborn errors of immunity are a group of rare genetically determined diseases that impair immune system development or function. Many of these diseases include immune dysregulation, autoimmunity, or autoinflammation as prominent clinical f…
View article: Human OTULIN mutations can cause distinct inflammatory disease phenotypes depending on the protein domain that is mutated
Human OTULIN mutations can cause distinct inflammatory disease phenotypes depending on the protein domain that is mutated Open
Linear ubiquitination is a post-translational modification that controls many immune signaling pathways. Linear ubiquitin chains are added to targets by LUBAC and removed by OTULIN, thus the opposing actions of LUBAC and OTULIN are critica…
View article: Topological-preserving membrane skeleton segmentation in multiplex immunofluorescence imaging
Topological-preserving membrane skeleton segmentation in multiplex immunofluorescence imaging Open
Multiplex immunofluorescence (MxIF) is an emerging imaging technology whose downstream molecular analytics highly rely upon the effectiveness of cell segmentation. In practice, multiple membrane markers (e.g., NaKATPase, PanCK and β-cateni…
View article: Pyroptosis-triggered pathogenesis: New insights on antiphospholipid syndrome
Pyroptosis-triggered pathogenesis: New insights on antiphospholipid syndrome Open
APS (antiphospholipid syndrome) is a systematic autoimmune disease presenting with the high levels of aPLs (antiphospholipid antibodies). These autoantibodies are involved in various clinical manifestations, mainly including arterial or ve…
View article: Supplementary Data from Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase
Supplementary Data from Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase Open
Supplementary Data from Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase
View article: Identification of thyroid hormone response genes in the remodeling of dorsal muscle during Microhyla fissipes metamorphosis
Identification of thyroid hormone response genes in the remodeling of dorsal muscle during Microhyla fissipes metamorphosis Open
Introduction Extensive morphological, biochemical, and cellular changes occur during anuran metamorphosis, which is triggered by a single hormone, thyroid hormone (TH). The function of TH is mainly mediated through thyroid receptor (TR) by…
View article: Comparative transcriptome analysis of rainbow trout gonadal cells (RTG-2) infected with U and J genogroup infectious hematopoietic necrosis virus
Comparative transcriptome analysis of rainbow trout gonadal cells (RTG-2) infected with U and J genogroup infectious hematopoietic necrosis virus Open
Infectious hematopoietic necrosis virus (IHNV) is the causative pathogen of infectious hematopoietic necrosis, outbreaks of which are responsible for significant losses in rainbow trout aquaculture. Strains of IHNV isolated worldwide have …