Kati Hokynar
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View article: A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification
A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification Open
SUMMARY In response to antigens, B cells undergo affinity maturation and class switching mediated by activation-induced cytidine deaminase (AID) in germinal centers (GCs) of secondary lymphoid organs, but uncontrolled AID activity can prec…
View article: Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles Open
Upon binding to pathogen or self-derived cytosolic nucleic acids cyclic GMP-AMP synthase (cGAS) triggers the production of cGAMP that further activates transmembrane protein STING. Upon activation STING translocates from ER via Golgi to ve…
View article: The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland
The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland Open
Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus (HSV) and human papillomavirus (HPV) cause sexually transmitted infections. In addition, human herpesvirus 6 (HHV-6) may be a genital co-pathogen. The prevalence rates of H…
View article: Predictive Values of Serum Chlamydia trachomatis TroA and HtrA IgG Antibodies as Markers of Persistent Infection in the Detection of Pelvic Adhesions and Tubal Occlusion
Predictive Values of Serum Chlamydia trachomatis TroA and HtrA IgG Antibodies as Markers of Persistent Infection in the Detection of Pelvic Adhesions and Tubal Occlusion Open
Chlamydia trachomatis IgG antibody testing (CAT) has been used as a screening test for tubal factor infertility (TFI), but as the CAT is only a marker of a past exposure to C. trachomatis and not of late sequelae, the positive predictive v…
View article: The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test
The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test Open
In 2019, more than 200 cases of Chlamydia trachomatis negative/equivocal by the Aptima Combo 2 assay (AC2, target: 23S rRNA) with slightly elevated relative light units (RLUs), but positive by the Aptima Chlamydia trachomatis assay (ACT, t…
View article: Mycoplasma pneumoniae outbreak, Southeastern Finland, 2017–2018: molecular epidemiology and laboratory diagnostic lessons
Mycoplasma pneumoniae outbreak, Southeastern Finland, 2017–2018: molecular epidemiology and laboratory diagnostic lessons Open
View article: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 Open
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA …
View article: Transcriptional Expression of the ompA, cpaf, tarp, and tox Genes of Chlamydia trachomatis Clinical Isolates at Different Stages of the Developmental Cycle
Transcriptional Expression of the ompA, cpaf, tarp, and tox Genes of Chlamydia trachomatis Clinical Isolates at Different Stages of the Developmental Cycle Open
The transcriptional gene expression patterns of Chlamydia trachomatis have mainly been studied using reference strains propagated in cultured cells. Here, using five low-passage-number C. trachomatis clinical isolates that originated from …
View article: Parachlamydia acanthamoebae Detected during a Pneumonia Outbreak in Southeastern Finland, in 2017–2018
Parachlamydia acanthamoebae Detected during a Pneumonia Outbreak in Southeastern Finland, in 2017–2018 Open
Community-acquired pneumonia (CAP) is a common disease responsible for significant morbidity and mortality. However, the definite etiology of CAP often remains unresolved, suggesting that unknown agents of pneumonia remain to be identified…
View article: Erratum for Hokynar et al., “Molecular Evidence of <i>Chlamydia</i> -Like Organisms in the Feces of <i>Myotis daubentonii</i> Bats”
Erratum for Hokynar et al., “Molecular Evidence of <i>Chlamydia</i> -Like Organisms in the Feces of <i>Myotis daubentonii</i> Bats” Open
Volume 83, no. 2, e02951-16, 2017, [https://doi.org/10.1128/AEM.02951-16][1]. Page 6, Materials and Methods, “Pan- Chlamydiales 16S rRNA PCR” paragraph, lines 6 and 7: There is a typographical error in the panCh-Fwd primer sequence; it sho…
View article: Correction: Hokynar, K. et al. Chlamydia-Like Organisms (CLOs) in Finnish Ixodes ricinus Ticks and Human Skin. Microorganisms 2016, 4, 28
Correction: Hokynar, K. et al. Chlamydia-Like Organisms (CLOs) in Finnish Ixodes ricinus Ticks and Human Skin. Microorganisms 2016, 4, 28 Open
The authors wish to make the following modification to this paper [...]
View article: Characterization of novel TMEM173 mutation with additive IFIH1 risk allele
Characterization of novel TMEM173 mutation with additive IFIH1 risk allele Open
TMEM173 encodes for STING that is a transmembrane protein activated by pathogen or self-derived cytosolic nucleic acids causing its translocation from ER to Golgi, and further to vesicles. Monogenic STING gain-of-function mutations cause e…
View article: Serum antibody response to Chlamydia trachomatis TroA and HtrA in women with tubal factor infertility
Serum antibody response to Chlamydia trachomatis TroA and HtrA in women with tubal factor infertility Open
View article: Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis Open
View article: Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria
Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria Open
A retrospective study of 109 skin biopsies with granuloma annulare (GA) or morphea histology from patients with suspected tick bite was performed. Biopsies were tested for cutaneous Borrelia burgdorferi DNA using PCR. The same biopsies wer…
View article: Simple and rapid biochemical method to synthesize labeled or unlabeled phosphatidylinositol species
Simple and rapid biochemical method to synthesize labeled or unlabeled phosphatidylinositol species Open
Phosphatidylinositol (PI) is the precursor of many important signaling molecules in eukaryotic cells and, most probably, PI also has important functions in cellular membranes. However, these functions are poorly understood, which is largel…
View article: Molecular Evidence of Chlamydia-Like Organisms in the Feces of Myotis daubentonii Bats
Molecular Evidence of Chlamydia-Like Organisms in the Feces of Myotis daubentonii Bats Open
Chlamydia -like organisms (CLOs) are recently identified members of the Chlamydiales order. CLOs share intracellular lifestyles and biphasic developmental cycles, and they have been detected in environmental samples as well as in various h…
View article: Antibody to Chlamydia trachomatis proteins, TroA and HtrA, as a biomarker for Chlamydia trachomatis infection
Antibody to Chlamydia trachomatis proteins, TroA and HtrA, as a biomarker for Chlamydia trachomatis infection Open
View article: Chlamydia-Like Organisms (CLOs) in Finnish Ixodes ricinus Ticks and Human Skin
Chlamydia-Like Organisms (CLOs) in Finnish Ixodes ricinus Ticks and Human Skin Open
Ticks carry several human pathogenic microbes including Borreliae and Flavivirus causing tick-born encephalitis. Ticks can also carry DNA of Chlamydia-like organisms (CLOs). The purpose of this study was to investigate the occurrence of CL…
View article: AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies
AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies Open
View article: The PNPLA-family phospholipases involved in glycerophospholipid homeostasis of HeLa cells
The PNPLA-family phospholipases involved in glycerophospholipid homeostasis of HeLa cells Open
View article: Substrate Efflux Propensity Is the Key Determinant of Ca2+-independent Phospholipase A-β (iPLAβ)-mediated Glycerophospholipid Hydrolysis
Substrate Efflux Propensity Is the Key Determinant of Ca2+-independent Phospholipase A-β (iPLAβ)-mediated Glycerophospholipid Hydrolysis Open