Kati Turkowski
YOU?
Author Swipe
View article: Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma
Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma Open
Lung adenocarcinoma (LUAD) is a biologically and clinically heterogeneous disease that poses a major challenge for prognosis and treatment. In this study, we performed proteomic profiling in a cohort of 88 LUAD patients to identify molecul…
View article: Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization
Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization Open
Tumor-associated macrophages (TAMs), including anti-tumor M1-like TAMs and pro-tumor M2-like TAMs, are transcriptionally dynamic innate immune cells with diverse roles in lung cancer development. Epigenetic regulators are key in controllin…
View article: Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization
Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization Open
Supplementary Data with figires_tables
View article: Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization
Supplementary Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization Open
Supplementary Data with figires_tables
CRISPR/Cas-Mediated Knockdown of PD-L1 and KRAS in Lung Cancer Cells Open
Cancer cells can escape death and surveillance by the host immune system in various ways. Programmed cell death ligand 1 (PD-L1) is a transmembrane protein that is expressed by most cell types, including cancer cells, and can provide an in…
Endothelin and the tumor microenvironment: a finger in every pie Open
The tumor microenvironment (TME) plays a central role in the development of cancer. Within this complex milieu, the endothelin (ET) system plays a key role by triggering epithelial-to-mesenchymal transition, causing degradation of the extr…
Supplementary Data from The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization Open
Supplementary Data with figires_tables
Data from The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization Open
Tumor-associated macrophages (TAM), including antitumor M1-like TAMs and protumor M2-like TAMs, are transcriptionally dynamic innate immune cells with diverse roles in lung cancer development. Epigenetic regulators are key in controlling m…
Supplementary Data from The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization Open
Supplementary Data with figires_tables
Data from The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization Open
Tumor-associated macrophages (TAM), including antitumor M1-like TAMs and protumor M2-like TAMs, are transcriptionally dynamic innate immune cells with diverse roles in lung cancer development. Epigenetic regulators are key in controlling m…
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system Open
Fibrocytes are bone marrow–derived monocytic cells implicated in wound healing. Here, we identify their role in lung cancer progression/ metastasis. Selective manipulation of fibrocytes in mouse lung tumor models documents the central role…
Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican Open
Transcription factors can serve as links between tumor microenvironment signaling and oncogenesis. Interferon regulatory factor 9 (IRF9) is recruited and expressed upon interferon stimulation and is dependent on cofactors that exert in tum…
Fibroblast Growth Factor—14 Acts as Tumor Suppressor in Lung Adenocarcinomas Open
Investigation of the molecular dynamics in lung cancer is crucial for the development of new treatment strategies. Fibroblast growth factor (FGF) 14 belongs to the FGF family, which might play a crucial role in cancer progression. We analy…
CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology Open
Glioblastoma multiforme (GBM) shows a high influx of tumor-associated macrophages (TAMs). The CCR2/CCL2 pathway is considered a relevant signal for the recruitment of TAMs and has been suggested as a therapeutic target in malignant gliomas…
The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC Open
Although immune checkpoint and targeted therapies offer remarkable benefits for lung cancer treatment, some patients do not qualify for these regimens or do not exhibit consistent benefit. Provided that lung cancer appears to be driven by …
Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy Open
Cancer research in recent decades has highlighted the potential influence of the tumor microenvironment on the progression and metastasis of most known cancer types. Within the established microenvironment, tumor-associated macrophages (TA…