Katia M. Harlé
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View article: Addressing pandemic-related guilt and shame in U.S. military veterans: A pilot randomized controlled trial of trauma-informed guilt reduction and supportive care therapy.
Addressing pandemic-related guilt and shame in U.S. military veterans: A pilot randomized controlled trial of trauma-informed guilt reduction and supportive care therapy. Open
Findings suggest that veterans with PTSD and guilt may benefit more from trauma- or morally injurious event-focused interventions like TrIGR, while veterans without PTSD may be adequately supported by SCT. Larger, more diverse samples are …
View article: A prospective study of pre-trauma fear learning and extinction as risk factors for posttraumatic stress disorder
A prospective study of pre-trauma fear learning and extinction as risk factors for posttraumatic stress disorder Open
Identifying risk for developing trauma-related disorders is a critical step in future prevention and intervention strategies. Impairments in inhibition of learned fear, such as safety signal learning and fear extinction, are suggested to b…
View article: Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Functional Outcomes in Alcohol Use Disorder: A Feasibility and Acceptability Pilot Study
Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Functional Outcomes in Alcohol Use Disorder: A Feasibility and Acceptability Pilot Study Open
To our knowledge, this is the first study to explore cervical nVNS as a potential new treatment for AUD-related symptoms. Findings provide support for feasibility of treatment delivery and patient acceptance, and initial evidence that nVNS…
View article: Bayesian deconvolution for computational cognitive modeling of fMRI data
Bayesian deconvolution for computational cognitive modeling of fMRI data Open
A central goal of cognitive neuroscience is to make inferences about underlying cognitive processes from observable data. However, current fMRI analysis tools cannot directly estimate latent parameters in computational cognitive models fro…
View article: Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens.
Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens. Open
View article: Motivational context and neurocomputation of stop expectation moderate early attention responses supporting proactive inhibitory control
Motivational context and neurocomputation of stop expectation moderate early attention responses supporting proactive inhibitory control Open
Alterations in attention to cues signaling the need for inhibitory control play a significant role in a wide range of psychopathology. However, the degree to which motivational and attentional factors shape the neurocomputations of proacti…
View article: 34 Neurocomputational Mechanisms of Social Reward Processing in Combat-Exposed Veterans
34 Neurocomputational Mechanisms of Social Reward Processing in Combat-Exposed Veterans Open
Objective: Combat exposure is associated with higher rates of depressive symptoms, including anhedonia (i.e., a reduced ability to seek and experience rewards) and feelings of social disconnectedness. While these symptoms are commonly docu…
View article: Approach avoidance training versus Sham in veterans with alcohol use disorder: protocol for a randomized controlled trial
Approach avoidance training versus Sham in veterans with alcohol use disorder: protocol for a randomized controlled trial Open
View article: State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa
State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa Open
View article: How Obstructed Action Efficacy Impacts Reward-Based Decision Making in Adolescent Depression: An fMRI Study
How Obstructed Action Efficacy Impacts Reward-Based Decision Making in Adolescent Depression: An fMRI Study Open
Adolescents with depression tend to exhibit less flexible behavioral orientation in the face of blocked action efficacy, and abnormalities in neural systems critical to regulating negative affect during reward-based decision making. This r…
View article: The effect of obstructed action efficacy on reward-based decision-making in healthy adolescents: a novel functional MRI task to assay frustration
The effect of obstructed action efficacy on reward-based decision-making in healthy adolescents: a novel functional MRI task to assay frustration Open
Frustration is common in adolescence and often interferes with executive functioning, particularly reward-based decision-making, and yet very little is known about how incidental frustrating events (independent of task-based feedback) disr…
View article: Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans
Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans Open
Background Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid and are associated with significant functional impairment and inconsistent treatment outcomes. Data-driven subtyping of this clinically hete…
View article: Higher affective congruency in the approach-avoidance task is associated with insular deactivation to dynamic facial expressions
Higher affective congruency in the approach-avoidance task is associated with insular deactivation to dynamic facial expressions Open
View article: Neural affective mechanisms associated with treatment responsiveness in veterans with PTSD and comorbid alcohol use disorder
Neural affective mechanisms associated with treatment responsiveness in veterans with PTSD and comorbid alcohol use disorder Open
View article: Proactive engagement of cognitive control modulates implicit approach-avoidance bias
Proactive engagement of cognitive control modulates implicit approach-avoidance bias Open
View article: Neurocomputational Changes in Inhibitory Control Associated With Prolonged Exposure Therapy
Neurocomputational Changes in Inhibitory Control Associated With Prolonged Exposure Therapy Open
Posttraumatic stress disorder (PTSD) is associated with inhibitory control dysfunction that extends beyond difficulties inhibiting trauma‐related intrusions. Inhibitory learning has been proposed as a potential mechanism of change underlyi…
View article: Bayesian computational markers of relapse in methamphetamine dependence
Bayesian computational markers of relapse in methamphetamine dependence Open
Methamphetamine use disorder is associated with a high likelihood of relapse. Identifying robust predictors of relapse that have explanatory power is critical to develop secondary prevention based on a mechanistic understanding of relapse.…
View article: Shared gray matter reductions across alcohol use disorder and posttraumatic stress disorder in the anterior cingulate cortex: A dual meta-analysis
Shared gray matter reductions across alcohol use disorder and posttraumatic stress disorder in the anterior cingulate cortex: A dual meta-analysis Open
The considerable comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) poses a greater public health burden than either condition alone. Although there is a substantial body of evidence linking the direct neur…
View article: Anhedonia and anxiety underlying depressive symptomatology have distinct effects on reward-based decision-making
Anhedonia and anxiety underlying depressive symptomatology have distinct effects on reward-based decision-making Open
Depressive pathology, which includes both heightened negative affect (e.g., anxiety) and reduced positive affect (e.g., anhedonia), is known to be associated with sub-optimal decision-making, particularly in uncertain environments. Here, w…
View article: Using Optimal Control to Disambiguate the Effect of Depression on Sensorimotor, Motivational and Goal-Setting Functions
Using Optimal Control to Disambiguate the Effect of Depression on Sensorimotor, Motivational and Goal-Setting Functions Open
Differentiating the ability from the motivation to act is of central importance to psychiatric disorders in general and depression in particular. However, it has been difficult to develop quantitative approaches to relate depression to poo…
View article: Reduced Neural Recruitment for Bayesian Adjustment of Inhibitory Control in Methamphetamine Dependence
Reduced Neural Recruitment for Bayesian Adjustment of Inhibitory Control in Methamphetamine Dependence Open
View article: Executive Function in Previously Institutionalized Children
Executive Function in Previously Institutionalized Children Open
In studies of children adopted from institutions, early institutionalization has been associated consistently with an increased risk of persistent cognitive, academic, and social‐emotional problems. These findings raise questions about the…
View article: Altered Statistical Learning and Decision-Making in Methamphetamine Dependence: Evidence from a Two-Armed Bandit Task
Altered Statistical Learning and Decision-Making in Methamphetamine Dependence: Evidence from a Two-Armed Bandit Task Open
Understanding how humans weigh long-term and short-term goals is important for both basic cognitive science and clinical neuroscience, as substance users need to balance the appeal of an immediate high vs. the long-term goal of sobriety. W…
View article: The Influence of Depression on Cognitive Control: Disambiguating Approach and Avoidance Tendencies
The Influence of Depression on Cognitive Control: Disambiguating Approach and Avoidance Tendencies Open
Dysfunctions of approach and avoidance motivation play an important role in depression, which in turn may affect cognitive control, i.e., the ability to regulate thoughts and action to achieve internal goals. We use a novel experimental pa…
View article: Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use
Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use Open
Bayesian ideal observer models quantify individuals' context- and experience-dependent beliefs and expectations about their environment, which provides a powerful approach (i) to link basic behavioural mechanisms to neural processing; and …