Explanipedia

Comparison of tetrabenazine, tiapride and olanzapine in Huntington's disease: a one-year French randomized multicenter study (Neuro-HD) Open

Katia Youssov, Étienne Audureau, Jérémie Pariente, Jean‐Philippe Azulay, Isabelle Bénatru , et al. · 2025

Olanzapine improved chorea, behavior, and irritability, although with a slight increase in rigidity. Tetrabenazine confirmed efficacy for chorea but was associated with mood disorders and drowsiness, while tiapride reduced irritability. Th…

Emotional speech markers of psychiatric disturbance in Huntington’s disease Open

Lucie Chenain, Audrey Fabre, Hadrien Titeux, Graça Morgado, Katia Youssov , et al. · 2025

Introduction Psychiatric disorders and difficulties in emotional expression represent a major problem in the management of Huntington’s Disease (HD). To improve patient follow-up, we propose to investigate the link between emotional expres…

The joint memory effect: challenging the selfish stigma in Huntington’s disease? Open

Romain Dalléry, Nicolas Fraisse, Laurent Cléret de Langavant, Katia Youssov, Graça Morgado , et al. · 2024

The prevalent belief that individuals with Huntington’s disease exhibit selfish behaviour, disregarding the thoughts, feelings and actions of others, has been challenged by patient organizations and clinical experts. To further investigate…

Cognitive reserve involves decision making and is associated with left parietal and hippocampal hypertrophy in neurodegeneration Open

Lorna Le Stanc, Marine Lunven, Maria Giavazzi, Agnès Sliwinski, Katia Youssov , et al. · 2024

Graph methods to infer spatial disturbances: Application to Huntington's Disease's speech Open

Lucie Chenain, Rachid Riad, Nicolas Fraisse, Cécilia Jubin, Graça Morgado , et al. · 2024

Dissociating cognitive compensation from cognitive deficit in neurodegenerative diseases: the model of premanifest Huntington’s disease mutation carriers Open

Charlotte Jacquemot, Lorna Le Stanc, Marine Lunven, Maria Giavazzi, Agnès Sliwinski , et al. · 2023

Cognitive reserve is the ability to actively cope with brain deterioration and delay cognitive decline in neurodegenerative diseases. We combined computational modelling (drift diffusion models, DDMs) and neuroanatomical analysis using Hun…

Language disorders in patients with striatal lesions: Deciphering the role of the striatum in language performance Open

Lorna Le Stanc, Katia Youssov, Maria Giavazzi, Agnès Sliwinski, Anne‐Catherine Bachoud‐Lévi , et al. · 2023

The classical neural model of language refers to a cortical network involving frontal, parietal and temporal regions. However, patients with subcortical lesions of the striatum have language difficulties. We investigated whether the striat…

A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington’s disease Open

Marine Lunven, Karen Hernandez Dominguez, Katia Youssov, Jennifer Hamet Bagnou, Rafika Fliss , et al. · 2023

Cognitive deficits represent a hallmark of neurodegenerative diseases, but evaluating their progression is complex. Most current evaluations involve lengthy paper-and-pencil tasks which are subject to learning effects dependent on the mode…

Language disorders in patients with striatal lesions: deciphering the role of the striatum in language performance Open

Lorna Le Stanc, Katia Youssov, Maria Giavazzi, Agnès Sliwinski, Anne‐Catherine Bachoud‐Lévi , et al. · 2022

The classical neural model of language refers to a network of cortical areas involving frontal, parietal and temporal regions. However, patients with a subcortical lesion of the striatum have language difficulties. We investigated whether …

The striatum in time production: The model of Huntington's disease in longitudinal study Open

Laurie Lemoine, Marine Lunven, Nicolas Fraisse, Katia Youssov, Blanche Bapst , et al. · 2022

The unified model of time processing suggests that the striatum is a central structure involved in all tasks that require the processing of temporal durations. Patients with Huntington's disease exhibit striatal degeneration and a deficit …

The burden of Huntington's disease: A prospective longitudinal study of patient/caregiver pairs Open

Katia Youssov, Étienne Audureau, Henri Vandendriessche, Graça Morgado, Richard Layese , et al. · 2022

Our results revealed the dynamics of caregiver burden over time in Huntington's disease, combining the stage of the disease, the severity of the patients' decline, psychiatric and behavioral disorders, and their evolution over time.

Emotion expression through spoken language in Huntington disease Open

Charlotte Gallezot, Rachid Riad, Hadrien Titeux, Laurie Lemoine, Justine Montillot , et al. · 2022

Patients with Huntington's disease suffer from disturbances in the perception of emotions; they do not correctly read the body, vocal and facial expressions of others. With regard to the expression of emotions, it has been shown that they …

Predicting clinical scores in Huntington’s disease: a lightweight speech test Open

Rachid Riad, Marine Lunven, Hadrien Titeux, Xuan-Nga Cao, Jennifer Hamet Bagnou , et al. · 2022

Corrigendum: Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy Open

Quang Nguyen, Juan Darío Ortigoza‐Escobar, Jean‐Marc Burgunder, Caterina Mariotti, Carsten Saft , et al. · 2022

[This corrects the article DOI: 10.3389/fneur.2022.817753.].

Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy Open

Quang Nguyen, Juan Darío Ortigoza‐Escobar, Jean‐Marc Burgunder, Caterina Mariotti, Carsten Saft , et al. · 2022

One percent of patients with a Huntington's disease (HD) phenotype do not have the Huntington (HTT) gene mutation. These are known as HD phenocopies. Their diagnosis is still a challenge. Our objective is to provide a diagnostic approach t…

Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington’s Disease Open

Pablo Lemercier, Laurent Cléret de Langavant, Jennifer Hamet Bagnou, Katia Youssov, Laurie Lemoine , et al. · 2022

Huntington’s Disease (HD) is an inherited neurodegenerative disease characterized by a combination of motor, cognitive, and behavioral disorders. The social and behavioral symptoms observed in HD patients impact their quality of life and p…

Cognitive decline in Huntington’s disease in the Digitalized Arithmetic Task (DAT) Open

Marine Lunven, Jennifer Hamet Bagnou, Katia Youssov, Alexis Gabadinho, Rafika Fliss , et al. · 2021

Background Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington’s disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combi…

Clinical description of the broad range of neurological presentations of COVID-19: A retrospective case series Open

Laurent Cléret de Langavant, Anne‐Cécile Petit, Nguyễn Quốc Trung, Thierry Gendre, Jihene Abdelhedi , et al. · 2021

Striatal connectivity in pre‐manifest Huntington’s disease is differentially affected by disease burden Open

Lorenzo Pini, Katia Youssov, Fabio Sambataro, Anne‐Catherine Bachoud‐Lévi, Antonino Vallesi , et al. · 2020

Background and purpose Different amounts of cumulative exposure to the toxic mutant form of the huntingtin protein might underlie the distinctive pattern of striatal connectivity in pre‐manifest Huntington’s disease (pre‐HD). The aim of th…

Attentional compensation in neurodegenerative diseases: the model of premanifest Huntington’s disease mutation carriers Open

Lorna Le Stanc, Marine Lunven, Maria Giavazzi, Agnès Sliwinski, Pierre Brugières , et al. · 2020

The ability of the brain to actively cope with neuropathological insults is known as neural compensation. It explains the delayed appearance of cognitive symptoms in neurodegenerative diseases. In contrast to the neural signature of compen…

International Guidelines for the Treatment of Huntington's Disease Open

Anne‐Catherine Bachoud‐Lévi, Joaquim J. Ferreira, Renaud Massart, Katia Youssov, Anne Rosser , et al. · 2019

The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday clinical practice for treatment of Huntington's disease (HD). The objectives of such gu…

COMT Val158Met Polymorphism Modulates Huntington's Disease Progression Open

Ruth de Diego‐Balaguer, Catherine Schramm, I. Rebeix, Emmanuel Dupoux, Alexandra Dürr , et al. · 2016

Little is known about the genetic factors modulating the progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Me…

Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington’s Disease Open

Linda Salem, Nadine Saleh, G. Désaméricq, Katia Youssov, Guillaume Dolbeau , et al. · 2016

IGF-1 levels, unlike insulin, predict the decline of cognitive function in HD.

Differential Response to ECT of Psychotic and Affective Symptoms in Huntington’s Disease: A Case Report Open

Anne‐Cécile Petit, Franz Hozer, Katia Youssov, Pierre Lavaud, Patrick Hardy , et al. · 2016

How to Capitalize on the Retest Effect in Future Trials on Huntington’s Disease Open

Catherine Schramm, Sandrine Katsahian, Katia Youssov, Jean‐François Démonet, Pierre Krystkowiak , et al. · 2015

The retest effect-improvement of performance on second exposure to a task-may impede the detection of cognitive decline in clinical trials for neurodegenerative diseases. We assessed the impact of the retest effect in Huntington's disease …

Longitudinal Study of Informed Consent in Innovative Therapy Research: Experience and Provisional Recommendations from a Multicenter Trial of Intracerebral Grafting Open

Laurent Cléret de Langavant, Sophie Sudraud, Christophe Verny, Pierre Krystkowiak, C. Simonin , et al. · 2015

Cognitively impaired patients with Huntington's disease were capable of consenting to participation in this trial. This consent procedure has presumably strengthened their understanding and should be proposed before signing the consent for…

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