Kara Bennett
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View article: Leveraging public health infrastructures to support sexual health for women living in the Southern United States
Leveraging public health infrastructures to support sexual health for women living in the Southern United States Open
Background Camellia is a single-arm longitudinal cohort study. We engaged a Community Advisory Board to support refinement of an existing mHealth app platform for use among cis- and transwomen in Alabama, one of seven states prioritized in…
View article: Use of tenofovir-based preexposure prophylaxis among pregnant women in South Africa
Use of tenofovir-based preexposure prophylaxis among pregnant women in South Africa Open
Objective: We developed Healthy Families-PrEP to support perinatal women to use HIV prevention strategies. Design: Single-arm study to evaluate PrEP use among pregnant women exposed to the intervention. Methods: We offered safer conception…
View article: Uptake and Persistence of Safer Conception Strategies Among South African Women Planning for Pregnancy
Uptake and Persistence of Safer Conception Strategies Among South African Women Planning for Pregnancy Open
Safer conception strategies can minimize HIV acquisition during periconception periods among women living in HIV-endemic areas. We examined uptake and predictors of persistent use of the same safer conception strategy among a cohort of HIV…
View article: Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa
Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa Open
Objective: We developed the Healthy Families-PrEP intervention to support HIV-prevention during periconception and pregnancy. We evaluated preexposure prophylaxis (PrEP) use with three objective measures. Design: This single-arm interventi…
View article: Cytomegalovirus Immunoglobulin G Levels and Subclinical Arterial Disease among People Living with HIV in Botswana: A Cross-Sectional Study
Cytomegalovirus Immunoglobulin G Levels and Subclinical Arterial Disease among People Living with HIV in Botswana: A Cross-Sectional Study Open
Cytomegalovirus (CMV) has been linked with increased cardiovascular risk and monocyte activation in people living with HIV (PLWH). This cross-sectional study aimed to compare CMV immunoglobulin G (IgG) levels between combined antiretrovira…
View article: No increased in utero and peripartum HIV acquisition risk in HIV-exposed preterm infants
No increased in utero and peripartum HIV acquisition risk in HIV-exposed preterm infants Open
There was no observed increase of in utero and peripartum HIV acquisition among infants born preterm following foetal exposure to HIV compared to those born at term.
View article: Adherence to daily, oral TDF/FTC PrEP during periconception among HIV-exposed South African women
Adherence to daily, oral TDF/FTC PrEP during periconception among HIV-exposed South African women Open
Background Daily, oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as pre-exposure prophylaxis (PrEP) reduces HIV acquisition for African women. Adherence is key to efficacy and patterns of adherence can be highly variable in rea…
View article: Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana
Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana Open
Broadly neutralizing antibodies (bNAbs) may provide an alternative to standard antiretroviral treatment (ART) for controlling HIV-1 replication and may have immunotherapeutic effects against HIV-1 reservoirs. We conducted a prospective cli…
View article: High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study
High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study Open
Background In Uganda, fertility rates and adult HIV prevalence are high, and many women conceive with partners living with HIV. Pre-exposure prophylaxis (PrEP) reduces HIV acquisition for women and, therefore, infants. We developed the Hea…
View article: Brief Report: Long-Term Clinical, Immunologic, and Virologic Outcomes Among Early-Treated Children With HIV in Botswana: A Nonrandomized Controlled Clinical Trial
Brief Report: Long-Term Clinical, Immunologic, and Virologic Outcomes Among Early-Treated Children With HIV in Botswana: A Nonrandomized Controlled Clinical Trial Open
Background: Early antiretroviral treatment (ART) improves outcomes in children, but few studies have comprehensively evaluated the impact of ART started from the first week of life. Methods: Children diagnosed with HIV within 96 hours of l…
View article: High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda
High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda Open
Background In Uganda, fertility rates and adult HIV prevalence are high, and many women conceive with partners living with HIV. Oral pre-exposure prophylaxis (PrEP) reduces HIV acquisition risk for women and, therefore, infants. We conduct…
View article: Safety and Pharmacokinetics of Intravenous 10-1074 and VRC01LS in Young Children
Safety and Pharmacokinetics of Intravenous 10-1074 and VRC01LS in Young Children Open
Background: Broadly neutralizing monoclonal antibodies (bNAbs) suppress HIV-1 RNA and may deplete residual viral reservoirs. We evaluated the safety and pharmacokinetics (PK) of dual intravenous VRC01LS and 10-1074 in very early-treated ch…
View article: Demonstration and Acceptability of a Safer Conception Intervention for Men With HIV in South Africa: Pilot Cohort Study
Demonstration and Acceptability of a Safer Conception Intervention for Men With HIV in South Africa: Pilot Cohort Study Open
Background Many men with HIV (MWH) want to have children. HIV viral suppression minimizes sexual HIV transmission risks while allowing for conception and optimization of the health of men, their partners, and their infants. Objective This …
View article: Demonstration and Acceptability of a Safer Conception Intervention for Men With HIV in South Africa: Pilot Cohort Study (Preprint)
Demonstration and Acceptability of a Safer Conception Intervention for Men With HIV in South Africa: Pilot Cohort Study (Preprint) Open
BACKGROUND Many men with HIV (MWH) want to have children. HIV viral suppression minimizes sexual HIV transmission risks while allowing for conception and optimization of the health of men, their partners, and their infants. OBJECTIVE Th…
View article: Labor epidural analgesia with severe thrombocytopenia
Labor epidural analgesia with severe thrombocytopenia Open
Thrombocytopenia in pregnancy could potentially lead to epidural hematoma and associated morbidity when neuraxial anesthesia is performed. We present a case of a 24-year-old parturient, who was otherwise healthy and without prior thrombocy…
View article: P099 High prevalence of curable sexually transmitted infections among HIV-uninfected women planning for pregnancy in KwaZulu-Natal, South Africa
P099 High prevalence of curable sexually transmitted infections among HIV-uninfected women planning for pregnancy in KwaZulu-Natal, South Africa Open
Background HIV-exposed women in African settings planning to conceive are at heightened risk of acquiring sexually transmitted infections (STIs). STIs can increase HIV acquisition risks and cause maternal and child morbidity. Here, we desc…
View article: Envelope following responses predict speech-in-noise performance in normal-hearing listeners
Envelope following responses predict speech-in-noise performance in normal-hearing listeners Open
Recent studies suggest that millions of people may be at risk of permanent impairment from cochlear synaptopathy, the age-related and noise-induced degeneration of neural connections in the inner ear. This study examines electrophysiologic…
View article: Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression
Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression Open
Background The impact of very early infant treatment on human immunodeficiency virus (HIV) reservoir, and markers for treatment success, require study. Methods The Early Infant Treatment Study (EIT) enrolled 40 children living with HIV sta…
View article: Decreased diarrheal and respiratory disease in HIV exposed uninfected children following vaccination with rotavirus and pneumococcal conjugate vaccines
Decreased diarrheal and respiratory disease in HIV exposed uninfected children following vaccination with rotavirus and pneumococcal conjugate vaccines Open
Background Rotavirus vaccine (RV) and pneumococcal vaccine (PCV) decrease diarrheal and respiratory disease incidence and severity, but there are few data about the effects of these vaccines among HIV-exposed uninfected (HEU) children. Met…
View article: Regulatory T Cells and the Risk of CMV End-Organ Disease in Patients With AIDS
Regulatory T Cells and the Risk of CMV End-Organ Disease in Patients With AIDS Open
Cytomegalovirus (CMV)-specific T-cell effectors (CMV-Teff) protect against CMV end-organ disease (EOD). In HIV-infected individuals, their numbers and function vary with CD4+ cell numbers and HIV load. The role of regulatory T cells (Treg)…
View article: Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial
Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial Open
Background Phylogenetic mapping of HIV-1 lineages circulating across defined geographical locations is promising for better understanding HIV transmission networks to design optimal prevention interventions. Methods We obtained near full-l…
View article: HIV diagnostic algorithm requires confirmatory testing for initial indeterminate or positive screens in the first week of life
HIV diagnostic algorithm requires confirmatory testing for initial indeterminate or positive screens in the first week of life Open
Background: Risk for nondiagnostic and false-positive HIV testing has not been quantified for neonates. Methods: From April 2015 to July 2018, we screened HIV-exposed infants in Botswana less than 96 h from birth by qualitative DNA PCR. Re…
View article: Mother-to-Child HIV Transmission With In Utero Dolutegravir vs. Efavirenz in Botswana
Mother-to-Child HIV Transmission With In Utero Dolutegravir vs. Efavirenz in Botswana Open
Background: A large-scale evaluation of mother-to-child transmission (MTCT) with dolutegravir (DTG)-based antiretroviral treatment (ART) has not been conducted previously. Setting: Botswana was the first African country to change from efav…
View article: PMTCT Adherence in Pregnant South African Women: The Role of Depression, Social Support, Stigma, and Structural Barriers to Care
PMTCT Adherence in Pregnant South African Women: The Role of Depression, Social Support, Stigma, and Structural Barriers to Care Open
Background Depression is a robust predictor of nonadherence to antiretroviral (ARV) therapy, which is essential to prevention of mother-to-child transmission (PMTCT). Women in resource-limited settings face additional barriers to PMTCT adh…
View article: Drug resistance after cessation of efavirenz-based antiretroviral treatment started in pregnancy
Drug resistance after cessation of efavirenz-based antiretroviral treatment started in pregnancy Open
Viral rebound was slow following cessation of EFV/FTC/TDF in the postpartum period. Use of an FTC/TDF tail after stopping EFV was associated with the lower prevalence of subsequent NNRTI drug resistance mutation.