Katie Hardman
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View article: Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases Open
Membrane-bound pyrophosphatases (mPPases) are homodimeric proteins that hydrolyse pyrophosphate and pump H+/Na+ across membranes. They are crucial for the virulence of protist pathogens, making them attractive drug targets. In this study, …
View article: Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters
Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters Open
SbmA is a membrane transporter from Escherichia coli that imports antimicrobial peptides. Although the protein is a secondary transporter that is energized by the proton gradient, it is structurally related to the transmembrane domain (TMD…
View article: Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases Open
Membrane-bound pyrophosphatases (mPPases) are homodimeric proteins that hydrolyse pyrophosphate and pump H+/Na+ across membranes. They are crucial for the virulence of protist pathogens, making them attractive drug targets. In this study, …
View article: Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases Open
Membrane-bound pyrophosphatases (mPPases) are homodimeric proteins that hydrolyse pyrophosphate and pump H + /Na + across membranes. They are crucial for the virulence of protist pathogens, making them attractive drug targets. In this stud…
View article: Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases Open
Membrane-bound pyrophosphatases (mPPases) are homodimeric proteins that hydrolyse pyrophosphate and pump H + /Na + across membranes. They are crucial for the virulence of protist pathogens, making them attractive drug targets. In this stud…
View article: Membrane force reception: mechanosensation in G protein-coupled receptors and tools to address it
Membrane force reception: mechanosensation in G protein-coupled receptors and tools to address it Open
To survive, all organisms must detect and respond to mechanical cues in their environment. Cells are subjected to a plethora of mechanical forces, such as hydrostatic pressure, cell-cell contact, stretch, compression, and shear stress. Mec…