Katie E. Hurst
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View article: Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment Open
The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. T cells in the TME …
View article: Acetyl-CoA Carboxylase Obstructs CD8<sup>+</sup>T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment
Acetyl-CoA Carboxylase Obstructs CD8<sup>+</sup>T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment Open
Summary The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor infiltrating T cells (TILs) hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. T cells in t…
View article: Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control
Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control Open
Summary The efficacy of cancer immunotherapies is limited by the metabolic instability of the tumor microenvironment (TME) that disables T cell antitumor immunity. Metabolic imbalances within the TME are sensed and responded to by stress s…
View article: Supplementary Table 1 from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity
Supplementary Table 1 from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity Open
Proteomics Table 1
View article: Supplementary Figures from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity
Supplementary Figures from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity Open
Supplementary Figs 1-4
View article: Supplementary Table 1 from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity
Supplementary Table 1 from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity Open
Proteomics Table 1
View article: Supplementary Figures from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity
Supplementary Figures from Remodeling Translation Primes CD8<sup>+</sup> T-cell Antitumor Immunity Open
Supplementary Figs 1-4
View article: Figure S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Figure S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
mtROS+ CD8 TILs are highly activated
View article: Data from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Data from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
Tumor antigen–specific T cells rapidly lose energy and effector function in tumors. The cellular mechanisms by which energy loss and inhibition of effector function occur in tumor-infiltrating lymphocytes (TILs) are ill-defined, and method…
View article: Figure S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Figure S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
Quantification and viability of T cell groups
View article: Table S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Table S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
FACS antibodies
View article: Figure S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Figure S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
mtROS+ CD8 TILs are highly activated
View article: Table S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Table S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
FACS antibodies
View article: Data from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Data from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
Tumor antigen–specific T cells rapidly lose energy and effector function in tumors. The cellular mechanisms by which energy loss and inhibition of effector function occur in tumor-infiltrating lymphocytes (TILs) are ill-defined, and method…
View article: Table S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Table S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
Protein Expression, Shotgun Proteomics
View article: Table S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Table S2 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
Protein Expression, Shotgun Proteomics
View article: Figure S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells
Figure S1 from Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8<sup>+</sup> T Cells Open
Quantification and viability of T cell groups
View article: Supplementary Table 1 from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Supplementary Table 1 from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Mixed linear modeling results for tumor curves
View article: Supplementary Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Supplementary Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Supplemental Figures S1-S11
View article: Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Protein synthesis supports robust immune responses. Nutrient competition and global cell stressors in the tumor microenvironment (TME) may impact protein translation in T cells and antitumor immunity. Using human and mouse tumors, we demon…
View article: Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Protein synthesis supports robust immune responses. Nutrient competition and global cell stressors in the tumor microenvironment (TME) may impact protein translation in T cells and antitumor immunity. Using human and mouse tumors, we demon…
View article: Supplementary Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Supplementary Data from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Supplemental Figures S1-S11
View article: Supplementary Table 1 from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Supplementary Table 1 from Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Mixed linear modeling results for tumor curves
View article: 1031 Acetyl CoA carboxylase inhibition rewires T cell fate and tumor immunotherapy outcome
1031 Acetyl CoA carboxylase inhibition rewires T cell fate and tumor immunotherapy outcome Open
Background Reshaping metabolism improves T cell tumor control 1-3, but direct enzymatic targets that restrict antitumor bioenergetics are poorly defined. Acetyl CoA Carboxylase (ACC) induces carboxylation of cytosolic Acetyl CoA to form Ma…
View article: Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer Open
Protein synthesis supports robust immune responses. Nutrient competition and global cell stressors in the tumor microenvironment (TME) may impact protein translation in T cells and antitumor immunity. Using human and mouse tumors, we demon…
View article: Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control
Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control Open
Protein synthesis enables cell growth and survival, but the molecular mechanisms through which T cells suppress or maintain protein translation in the stress of solid tumors are unknown. Using mouse models and human tumors we demonstrate t…
View article: 522 Metabolic requisites for T cell protein translation in tumors
522 Metabolic requisites for T cell protein translation in tumors Open
Background T cells are a secretory immune subset with the capacity to control solid tumors. Protein translation is of paramount importance in CD8 T cells, controlling proliferation, stimulation and lineage fate. Methods Herein, we used bot…
View article: Remodeling Translation Primes CD8+ T-cell Antitumor Immunity
Remodeling Translation Primes CD8+ T-cell Antitumor Immunity Open
The requisites for protein translation in T cells are poorly understood and how translation shapes the antitumor efficacy of T cells is unknown. Here we demonstrated that IL15-conditioned T cells were primed by the metabolic energy sensor …
View article: Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors
Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors Open
Effective cancer therapies simultaneously restrict tumor cell growth and improve anti-tumor immune responses. Targeting redox-dependent protein folding enzymes within the endoplasmic reticulum (ER) is an alternative approach to activation …