Katie M. Dixon
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View article: Uncovering the efficacy of a natural homemade sunscreen in protection from ultraviolet radiation
Uncovering the efficacy of a natural homemade sunscreen in protection from ultraviolet radiation Open
In Australia, skin cancer has the highest incidence of all cancer types, where Therapeutic Goods Association-approved, broad-spectrum sunscreens are recommended to prevent skin carcinogenesis. Commercial sunscreen ingredients, however, hav…
View article: Ultraviolet and infrared radiation in Australia: assessing the benefits, risks, and optimal exposure guidelines
Ultraviolet and infrared radiation in Australia: assessing the benefits, risks, and optimal exposure guidelines Open
Despite extensive research, determining the optimal level of sunlight exposure for human health remains a challenge, emphasizing the need for ongoing scientific inquiry into this critical aspect of human well-being. This review aims to elu…
View article: Malignant Melanoma: An Overview, New Perspectives, and Vitamin D Signaling
Malignant Melanoma: An Overview, New Perspectives, and Vitamin D Signaling Open
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and a high mortality rate. This …
View article: 1,25-Dihydroxyvitamin D3 Suppresses UV-Induced Poly(ADP-Ribose) Levels in Primary Human Keratinocytes, as Detected by a Novel Whole-Cell ELISA
1,25-Dihydroxyvitamin D3 Suppresses UV-Induced Poly(ADP-Ribose) Levels in Primary Human Keratinocytes, as Detected by a Novel Whole-Cell ELISA Open
Photoprotective properties of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) to reduce UV-induced DNA damage have been established in several studies. UV-induced DNA damage in skin such as single or double strand breaks is known to initiate severa…
View article: Cyclic AMP-regulatory element-binding protein: a novel UV-targeted transcription factor in skin cancer
Cyclic AMP-regulatory element-binding protein: a novel UV-targeted transcription factor in skin cancer Open
Common therapeutics in relation to melanoma and non-melanoma cancers include the use of kinase inhibitors. The long-term benefits of kinases, however, are limited by development of drug resistance. An alternative approach for treatment wou…
View article: Developing rights-based standards for children having tests, treatments, examinations and interventions: using a collaborative, multi-phased, multi-method and multi-stakeholder approach to build consensus
Developing rights-based standards for children having tests, treatments, examinations and interventions: using a collaborative, multi-phased, multi-method and multi-stakeholder approach to build consensus Open
Children continue to experience harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. The international ISupport collaboration aimed to develop standards to outline …
View article: The Over-Irradiation Metabolite Derivative, 24-Hydroxylumister-ol3, Reduces UV-Induced Damage in Skin
The Over-Irradiation Metabolite Derivative, 24-Hydroxylumister-ol3, Reduces UV-Induced Damage in Skin Open
The hormonal form of vitamin D3, 1,25(OH)2D3, reduces UV-induced DNA damage. UV exposure initiates pre-vitamin D3 production in the skin, and continued UV exposure photoisomerizes pre-vitamin D3 to produce “over-irradiation products” such …
View article: The CaSR Modulator NPS-2143 Reduced UV-Induced DNA Damage in Skh:hr1 Hairless Mice but Minimally Inhibited Skin Tumours
The CaSR Modulator NPS-2143 Reduced UV-Induced DNA Damage in Skh:hr1 Hairless Mice but Minimally Inhibited Skin Tumours Open
The calcium-sensing receptor (CaSR) is an important regulator of epidermal function. We previously reported that knockdown of the CaSR or treatment with its negative allosteric modulator, NPS-2143, significantly reduced UV-induced DNA dama…
View article: 261 Collaborative development of the international ‘Rights-based standards for children undergoing a clinical procedure’
261 Collaborative development of the international ‘Rights-based standards for children undergoing a clinical procedure’ Open
Aims The consensus method approach which ran throughout 2021 involved six decision-making meetings with the international collaborative group and 155 responses to the online survey from children, parents and health professionals from acros…
View article: PTEN as a target in melanoma
PTEN as a target in melanoma Open
PTEN is a well-known tumour suppressor protein that is frequently found to be mutated, inactivated or deleted in a wide range of different cancers. Its tumour suppressive properties result predominantly from its inhibitory effects on the P…
View article: Evidence for Involvement of Nonclassical Pathways in the Protection From <scp>UV</scp>‐Induced <scp>DNA</scp> Damage by Vitamin D–Related Compounds
Evidence for Involvement of Nonclassical Pathways in the Protection From <span>UV</span>‐Induced <span>DNA</span> Damage by Vitamin D–Related Compounds Open
The vitamin D hormone, 1,25dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), and related compounds derived from vitamin D 3 or lumisterol as a result of metabolism via the enzyme CYP11A1, have been shown, when applied 24 hours before or immediately …
View article: Sex Differences in Photoprotective Responses to 1,25-Dihydroxyvitamin D3 in Mice Are Modulated by the Estrogen Receptor-β
Sex Differences in Photoprotective Responses to 1,25-Dihydroxyvitamin D3 in Mice Are Modulated by the Estrogen Receptor-β Open
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β−/−) mice. We previously reported that the active vitamin…
View article: Sex Differences in Photoprotective Responses to 1,25- Dihydroxyvitamin D3 in Mice are Modulated by the Estrogen Receptor-β
Sex Differences in Photoprotective Responses to 1,25- Dihydroxyvitamin D3 in Mice are Modulated by the Estrogen Receptor-β Open
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vi…
View article: Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic
Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic Open
Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper…
View article: Are You Faux Real
Are You Faux Real Open
The art market is a high-risk industry, in which authentication is the sina qua non of merchantability. In an era of increased market capitalization and ever-growing demand for fine art—either for the status it confers on its owners qua ar…
View article: Skin protective effects of RM191A, a novel superoxide dismutase mimetic
Skin protective effects of RM191A, a novel superoxide dismutase mimetic Open
Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water soluble, dimeric coppe…
View article: Protective effects of 1,25 dihydroxyvitamin D<sub>3</sub> and its analogs on ultraviolet radiation-induced oxidative stress: a review
Protective effects of 1,25 dihydroxyvitamin D<sub>3</sub> and its analogs on ultraviolet radiation-induced oxidative stress: a review Open
The active vitamin D compound, 1,25-dihydroxyvitamin D3 (1,25D) is produced in skin cells following exposure to ultraviolet radiation (UV) from the sun. However, there are many harmful effects of UV which include DNA damage caused by direc…
View article: Enhanced Repair of UV-Induced DNA Damage by 1,25-Dihydroxyvitamin D3 in Skin Is Linked to Pathways that Control Cellular Energy
Enhanced Repair of UV-Induced DNA Damage by 1,25-Dihydroxyvitamin D3 in Skin Is Linked to Pathways that Control Cellular Energy Open