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View article: Longitudinal high-frequency blood biomarkers of axonal injury and astrocytic activation after immune reconstitution in multiple sclerosis
Longitudinal high-frequency blood biomarkers of axonal injury and astrocytic activation after immune reconstitution in multiple sclerosis Open
Background .Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) reflect axonal damage and astrocytic injury. Their clinical role in longitudinal real-world monitoring after immune reconstitution therapy (IRT)…
View article: Serum glial fibrillary protein reflects early brain injury dynamics and cognitive changes after deep brain stimulation surgery
Serum glial fibrillary protein reflects early brain injury dynamics and cognitive changes after deep brain stimulation surgery Open
View article: Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control
Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control Open
To ensure goal-directed behavior in daily life, the use of inhibitory control is of great importance. The aim of this study is to shed light on the underlying neuronal mechanisms of inhibitory control and the relevance of cytoarchitectonic…
View article: Extensive T-Cell Profiling Following SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis Patients Treated with DMTs
Extensive T-Cell Profiling Following SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis Patients Treated with DMTs Open
Disease-modifying therapies (DMTs) are known to impact cellular and humoral immune response in persons with multiple sclerosis (pwMS). In this study, we performed in-depth SARS-CoV-2-specific T-cell profiling using flow cytometry. T-cell i…
View article: Cost–consequence analysis of early vs. delayed natalizumab use in highly active relapsing–remitting multiple sclerosis: a simulation study
Cost–consequence analysis of early vs. delayed natalizumab use in highly active relapsing–remitting multiple sclerosis: a simulation study Open
Background Natalizumab (NAT) is an established disease-modifying therapy (DMT) for highly active multiple sclerosis (MS). However, its use involves complex decision-making, often leading to initial use of lower efficacy therapies. Recently…
View article: Machine learning integration of MRI and gait reveals mobility phenotypes in multiple sclerosis
Machine learning integration of MRI and gait reveals mobility phenotypes in multiple sclerosis Open
Mobility impairment is a hallmark of disease worsening in multiple sclerosis (MS), yet its phenotypic diversity and pathophysiology mechanisms are not completely understood. Conventional gait assessments often rely on subjective clinical m…
View article: MS brain health quality standards: a survey on the reality in clinical practice in Germany
MS brain health quality standards: a survey on the reality in clinical practice in Germany Open
Background The quality of treatment is especially critical in the context of complex and chronic diseases such as multiple sclerosis (MS). The Brain Health Initiative, an independent international consortium of neurologists, reached a cons…
View article: Serum Glial Fibrillary Acidic Protein (GFAP) as a Potential Biomarker for Monitoring Postoperative Complications in Deep Brain Stimulation Surgery
Serum Glial Fibrillary Acidic Protein (GFAP) as a Potential Biomarker for Monitoring Postoperative Complications in Deep Brain Stimulation Surgery Open
Deep brain stimulation (DBS) is an efficient treatment for movement disorders, most commonly Parkinson’s Disease (PD), dystonia and essential tremor. DBS surgery carries risks, e.g. the risk of delayed peri-lead edema (PLE) and the risk of…
View article: Integrating large language models in care, research, and education in multiple sclerosis management
Integrating large language models in care, research, and education in multiple sclerosis management Open
Use of techniques derived from generative artificial intelligence (AI), specifically large language models (LLMs), offer a transformative potential on the management of multiple sclerosis (MS). Recent LLMs have exhibited remarkable skills …
View article: Long-term effects of siponimod on cardiovascular and autonomic nervous system in secondary progressive multiple sclerosis
Long-term effects of siponimod on cardiovascular and autonomic nervous system in secondary progressive multiple sclerosis Open
Background Siponimod, a second-generation, selective sphingosine 1-phosphate receptor (S1PR) 1 and 5 modulator, represents an important therapeutic choice for active secondary progressive multiple sclerosis (SPMS). Besides the beneficial i…
View article: Serum neurofilament light chain as a sensitive biomarker for neuromonitoring during extracorporeal membrane oxygenation
Serum neurofilament light chain as a sensitive biomarker for neuromonitoring during extracorporeal membrane oxygenation Open
View article: Raman Spectroscopy of Optically Trapped Living Human T Cell Subsets and Monocytes
Raman Spectroscopy of Optically Trapped Living Human T Cell Subsets and Monocytes Open
In recent years, Raman spectroscopy has garnered growing interest in the field of biomedical research. It offers a non-invasive and label-free approach to defining the molecular fingerprint of immune cells. We utilized Raman spectroscopy o…
View article: SARS-CoV-2-Specific Immune Cytokine Profiles to mRNA, Viral Vector and Protein-Based Vaccines in Patients with Multiple Sclerosis: Beyond Interferon Gamma
SARS-CoV-2-Specific Immune Cytokine Profiles to mRNA, Viral Vector and Protein-Based Vaccines in Patients with Multiple Sclerosis: Beyond Interferon Gamma Open
Disease-modifying therapies (DMTs) impact the cellular immune response to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccines in patients with multiple sclerosis (pwMS). In this study, we aim to elucidate the charact…
View article: Corticosteroid-depending effects on peripheral immune cell subsets vary according to disease modifying strategies in multiple sclerosis
Corticosteroid-depending effects on peripheral immune cell subsets vary according to disease modifying strategies in multiple sclerosis Open
Background The primary treatment for acute relapses in multiple sclerosis (MS) is the intravenous administration of high-dose methylprednisolone (IVMP). However, the mechanisms through which corticosteroid treatment impacts acute neuroinfl…
View article: Challenges in monitoring the quality of care in multiple sclerosis—authors' reply
Challenges in monitoring the quality of care in multiple sclerosis—authors' reply Open
View article: Consensus quality indicators for monitoring multiple sclerosis
Consensus quality indicators for monitoring multiple sclerosis Open
Multiple sclerosis (MS) as a chronic, degenerative autoimmune disease of the central nervous system has a longitudinal and heterogeneous course with increasing treatment options and risk profiles requiring constant monitoring of a growing …
View article: Insights from Real-World Practice: The Dynamics of SARS-CoV-2 Infections and Vaccinations in a Large German Multiple Sclerosis Cohort
Insights from Real-World Practice: The Dynamics of SARS-CoV-2 Infections and Vaccinations in a Large German Multiple Sclerosis Cohort Open
The SARS-CoV-2 pandemic profoundly impacted people with multiple sclerosis (pwMS). Disease-related aspects and demographic factors may influence vaccination rates, infection susceptibility, and severity. Despite prior research, comprehensi…
View article: Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance
Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance Open
Summary Obstructive sleep apnea is associated with cognitive impairment and increased risk for neurodegenerative diseases. Obstructive sleep apnea treatment with positive airway pressure therapy helps to improve cognitive symptoms and redu…
View article: Repeated iv <scp>anti‐CD20</scp> treatment in multiple sclerosis: Long‐term effects on peripheral immune cell subsets
Repeated iv <span>anti‐CD20</span> treatment in multiple sclerosis: Long‐term effects on peripheral immune cell subsets Open
Objective Repeated intravenous administration of anti‐CD20 depleting monoclonal antibodies 6 months apart is among the highly effective treatment options in multiple sclerosis (MS). Here, we aimed to investigate peripheral immune cell subs…
View article: Serum neurofilament indicates accelerated neurodegeneration and predicts mortality in late-stage Parkinson’s disease
Serum neurofilament indicates accelerated neurodegeneration and predicts mortality in late-stage Parkinson’s disease Open
Different stages of Parkinson’s disease (PD) are defined by clinical criteria, while late-stage PD is marked by the onset of morbidity milestones and rapid clinical deterioration. Based on neuropathological evidence, degeneration in the do…
View article: Change from platform to high efficacy disease-modifying treatment for multiple sclerosis despite NEDA
Change from platform to high efficacy disease-modifying treatment for multiple sclerosis despite NEDA Open
We report the case of a relapsing multiple sclerosis (RMS) patient, who, in light of the recent insights demonstrating the potential of high-efficacy disease modifying treatments (heDMT) to delay secondary progression, requested changing h…
View article: Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis
Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis Open
Interpretation of blood NfL values may vary markedly depending on the selection of the reference resource. Borderline elevated values should be interpreted with caution, and future studies should focus on standardizing NfL measurement and …
View article: Differential effects of selective versus unselective sphingosine 1-phosphate receptor modulators on T- and B-cell response to SARS-CoV-2 vaccination
Differential effects of selective versus unselective sphingosine 1-phosphate receptor modulators on T- and B-cell response to SARS-CoV-2 vaccination Open
Background: Sphingosine 1-phosphat receptor modulators (S1PRMs) have been linked to attenuated immune response to SARS-CoV-2 vaccines. Objective: To characterize differences in the immune response to SARS-CoV-2 vaccines in patients on sele…
View article: Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury
Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury Open
Objectives Neurofilament light chain (NfL) has emerged as a promising biomarker for detecting and monitoring axonal injury. Until recently, NfL could only be reliably measured in cerebrospinal fluid, but digital single molecule array (Simo…
View article: Long-Term Immune Response Profiles to SARS-CoV-2 Vaccination and Infection in People with Multiple Sclerosis on Anti-CD20 Therapy
Long-Term Immune Response Profiles to SARS-CoV-2 Vaccination and Infection in People with Multiple Sclerosis on Anti-CD20 Therapy Open
Our objective was to analyze longitudinal cellular and humoral immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in people with multiple sclerosis (pwMS) on B-cell depleting treatment (BCDT) compa…
View article: Can ChatGPT explain it? Use of artificial intelligence in multiple sclerosis communication
Can ChatGPT explain it? Use of artificial intelligence in multiple sclerosis communication Open
View article: Influence of Pre-Analytic Conditions on Quantity of Lymphocytes
Influence of Pre-Analytic Conditions on Quantity of Lymphocytes Open
Lymphocytes are key players in the pathogenesis of multiple sclerosis and a distinct target of several immunomodulatory treatment strategies. In this study, we aim to evaluate the effect of various pre-analytic conditions on immune cell co…
View article: Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers
Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers Open
The acute state of anorexia nervosa (AN) is associated with widespread reductions in cortical gray matter (GM) thickness and white matter (WM) volume, suspected changes in myelin content and elevated levels of the neuronal damage marker ne…
View article: Pilot study on the influence of acute alcohol exposure on biophysical parameters of leukocytes
Pilot study on the influence of acute alcohol exposure on biophysical parameters of leukocytes Open
Objective: This pilot study explores the influence of acute alcohol exposure on cell mechanical properties of steady-state and activated leukocytes conducted with real-time deformability cytometry. Methods: Nineteen healthy male volunteers…
View article: Classifying flow cytometry data using Bayesian analysis helps to distinguish ALS patients from healthy controls
Classifying flow cytometry data using Bayesian analysis helps to distinguish ALS patients from healthy controls Open
Introduction Given its wide availability and cost-effectiveness, multidimensional flow cytometry (mFC) became a core method in the field of immunology allowing for the analysis of a broad range of individual cells providing insights into c…