Katja Röper
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View article: Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration
Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration Open
Expression Atlas (https://www.ebi.ac.uk/gxa/home) is EMBL-EBI’s comprehensive knowledgebase for gene and protein expression across tissues, cell types, conditions, and multiple species. Since our last update, Expression Atlas has expanded …
View article: Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration
Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration Open
Expression Atlas (https://www.ebi.ac.uk/gxa/home) is EMBL-EBI’s comprehensive knowledgebase for gene and protein expression across tissues, cell types, conditions, and multiple species. Since our last update, Expression Atlas has expanded …
View article: Supracellular actomyosin assemblies: master coordinators of development
Supracellular actomyosin assemblies: master coordinators of development Open
Most movement in biological systems is driven by assemblies of actomyosin, be it in the form of sarcomeres in muscles or as actomyosin networks in non-muscle cells. Actomyosin has several key functions within epithelial cells, the cells th…
View article: Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs
Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs Open
How tissue shape and therefore function is encoded by the genome remains in many cases unresolved. The tubes of the salivary glands in the Drosophila embryo start from simple epithelial placodes, specified through the homeotic factors Scr/…
View article: β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis
β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis Open
Coordinated cell shape changes are a major driver of tissue morphogenesis, with apical constriction of epithelial cells leading to tissue bending. We previously identified that interplay between the apical-medial actomyosin, which drives a…
View article: Single cell transcriptomics of the<i>Drosophila</i>embryonic salivary gland reveals not only induction but also exclusion of expression as key morphogenetic control steps
Single cell transcriptomics of the<i>Drosophila</i>embryonic salivary gland reveals not only induction but also exclusion of expression as key morphogenetic control steps Open
How tissue shape and therefore function is encoded by the genome remains in many cases unresolved. The tubes of the salivary glands in the Drosophila embryo start from simple epithelial placodes, specified through the homeotic factors Scr/…
View article: β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis
β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis Open
Coordinated cell shape changes are a major driver of tissue morphogenesis during development, with apical constriction or wedging of groups of epithelial cells for instance leading to tissue bending in folding or budding processes. During …
View article: Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension
Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension Open
Toll-like receptors (TLRs) in mammalian systems are well known for their role in innate immunity. In addition, TLRs also fulfil crucial functions outside immunity, including the dorsoventral patterning function of the original Toll recepto…
View article: Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transition
Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transition Open
Summary During kidney development, nephron epithelia arise de novo from fate-committed mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET). Downstream of fate specification, transcriptional mechanisms that drive es…
View article: Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks
Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks Open
During morphogenesis, large-scale changes of tissue primordia are coordinated across an embryo. In Drosophila, several tissue primordia and embryonic regions are bordered or encircled by supracellular actomyosin cables, junctional actomyos…
View article: Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks
Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks Open
During morphogenesis, large scale changes of tissue primordia occur that are all coordinated across an embryo. In Drosophila , several tissue primordia and embryonic regions are bordered or encircled by supracellular actomyosin cables, jun…
View article: Correct regionalization of a tissue primordium is essential for coordinated morphogenesis
Correct regionalization of a tissue primordium is essential for coordinated morphogenesis Open
During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors of cell wed…
View article: Author response: Correct regionalization of a tissue primordium is essential for coordinated morphogenesis
Author response: Correct regionalization of a tissue primordium is essential for coordinated morphogenesis Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract During organ developme…
View article: A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding Open
Non-centrosomal microtubule arrays serve crucial functions in cells, yet the mechanisms of their generation are poorly understood. During budding of the epithelial tubes of the salivary glands in the Drosophila embryo, we previously demons…
View article: “Neur”al brain wave: Coordinating epithelial-to-neural stem cell transition in the fly optic lobe
“Neur”al brain wave: Coordinating epithelial-to-neural stem cell transition in the fly optic lobe Open
In the Drosophila larval optic lobe, the generation of neural stem cells involves an epithelial-to-mesenchymal–like transition of a continuous stripe of cells that sweeps across the neuroepithelium, but the dynamics at cell and tissue leve…
View article: Correct regionalisation of a tissue primordium is essential for coordinated morphogenesis
Correct regionalisation of a tissue primordium is essential for coordinated morphogenesis Open
During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviours of cell we…
View article: Microtubules enter centre stage for morphogenesis
Microtubules enter centre stage for morphogenesis Open
Cell shape changes are key to observable changes at the tissue level during morphogenesis and organ formation. The major driver of cell shape changes in turn is the actin cytoskeleton, both in the form of protrusive linear or branched dyna…
View article: A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding Open
Non-centrosomal microtubule arrays serve crucial functions in cells, yet the mechanisms of their generation are poorly understood. During budding of the epithelial tubes of the salivary glands in the Drosophila embryo, we previously demons…
View article: The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation
The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation Open
Coordination between different cytoskeletal systems is crucial for many cell biological functions, including cell migration and mitosis, and also plays an important role during tissue morphogenesis. Proteins of the class of cytoskeletal cr…
View article: Rho-Kinase Planar Polarization at Tissue Boundaries Depends on Phospho-regulation of Membrane Residence Time
Rho-Kinase Planar Polarization at Tissue Boundaries Depends on Phospho-regulation of Membrane Residence Time Open
The myosin II activator Rho-kinase (Rok) is planar polarized at the tissue boundary of the Drosophila embryonic salivary gland placode through a negative regulation by the apical polarity protein Crumbs that is anisotropically localized at…
View article: Rho-kinase planar polarisation at tissue boundaries depends on phospho-regulation of membrane residence time
Rho-kinase planar polarisation at tissue boundaries depends on phospho-regulation of membrane residence time Open
Summary Rho-kinase (Rok) is a major myosin II activator during morphogenesis. In the Drosophila embryonic salivary gland placode Rok is planar polarised at the tissue boundary, through a negative regulation by the apical polarity protein C…
View article: Radially patterned cell behaviours during tube budding from an epithelium
Radially patterned cell behaviours during tube budding from an epithelium Open
The budding of tubular organs from flat epithelial sheets is a vital morphogenetic process. Cell behaviours that drive such processes are only starting to be unraveled. Using live-imaging and novel morphometric methods, we show that in add…
View article: Author response: Radially patterned cell behaviours during tube budding from an epithelium
Author response: Radially patterned cell behaviours during tube budding from an epithelium Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The budding of tubular organs…
View article: Radially-patterned cell behaviours during tube budding from an epithelium
Radially-patterned cell behaviours during tube budding from an epithelium Open
The budding of tubular organs from flat epithelial sheets is a vital morphogenetic process. Cell behaviours that drive such processes are only starting to be unraveled. Using live imaging and novel morphometric methods we show that in addi…
View article: Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination Open
Neural stem cells or neuroblasts in the Drosophila melanogaster embryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system. Using this accessible system to examine the molecular mechanisms of cell ing…
View article: The spectraplakin Short stop is an essential microtubule regulator involved in epithelial closure in <i>Drosophila</i>
The spectraplakin Short stop is an essential microtubule regulator involved in epithelial closure in <i>Drosophila</i> Open
Dorsal closure of the Drosophila embryonic epithelium provides an excellent model system for the in vivo analysis of molecular mechanisms regulating cytoskeletal rearrangements. In this study, we investigated the function of the Drosophila…