Katja Zscheppang
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View article: A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential
A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential Open
We investigated in a unique setup of animal models and a human lung explant culture biological properties, including zoonotic potential, of a representative 2016 highly pathogenic avian influenza virus (HPAIV) H5N8, clade 2.3.4.4 group B (…
View article: Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA
Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA Open
View article: THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila – a systems biology study
THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila – a systems biology study Open
View article: Human Pulmonary 3D Models For Translational Research
Human Pulmonary 3D Models For Translational Research Open
Lung diseases belong to the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bron…
View article: Tyk2 as a target for immune regulation in human viral/bacterial pneumonia
Tyk2 as a target for immune regulation in human viral/bacterial pneumonia Open
The severity and lethality of influenza A virus (IAV) infections is frequently aggravated by secondary bacterial pneumonia. However, the mechanisms in human lung tissue that provoke this increase in fatality are unknown and therapeutic imm…
View article: Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells
Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells Open
In the HNSCC model, sphere-forming conditions select for cells, which are unsusceptible to both anti-β1 integrin and anti-EGFR inhibitory antibodies. With regard to primary and secondary sphere formation, our data suggest that both of thes…
View article: Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer
Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer Open
Concomitant targeting of β1 integrin and EGFR seems a powerful and promising approach to overcome radioresistance of HNSCCs.