Katlyn E. Koepp
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View article: Myocardial histopathology by cardiac biopsy enhances phenotyping of heart failure with preserved ejection fraction
Myocardial histopathology by cardiac biopsy enhances phenotyping of heart failure with preserved ejection fraction Open
Background In patients with heart failure with preserved ejection fraction (HFpEF), studies have described different HFpEF phenogroups based on medical comorbidities and variable echocardiographic, invasive hemodynamic, and biomarker data.…
View article: Surgical pericardiotomy to treat heart failure with preserved ejection fraction: a first clinical study
Surgical pericardiotomy to treat heart failure with preserved ejection fraction: a first clinical study Open
Journal Article Surgical pericardiotomy to treat heart failure with preserved ejection fraction: a first clinical study Get access Barry A Borlaug, Barry A Borlaug Department of Cardiovascular Medicine, Mayo Clinic and Foundation, 200 Firs…
View article: Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection Fraction
Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection Fraction Open
Importance Reduced heart rate during exercise is common and associated with impaired aerobic capacity in heart failure with preserved ejection fraction (HFpEF), but it remains unknown if restoring exertional heart rate through atrial pacin…
View article: Peripheral and pulmonary effects of <scp>inorganic nitrite</scp> during exercise in heart failure with preserved ejection fraction
Peripheral and pulmonary effects of <span>inorganic nitrite</span> during exercise in heart failure with preserved ejection fraction Open
Aims To determine whether inorganic nitrite improves peripheral and pulmonary oxygen (O 2 ) transport during exercise in heart failure with preserved ejection fraction (HFpEF). Methods and results Data from two invasive, randomized, double…
View article: Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction
Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction Open
Aims Central obesity is a major risk factor for heart failure with preserved ejection fraction (HFpEF), particularly in women, but the mechanisms remain unclear. We hypothesized that sex-specific differences in visceral adipose tissue (VAT…
View article: Fat Mass Index Better Identifies Metabolic Syndrome: Insights from Patients in Early Outpatient Cardiac Rehabilitation
Fat Mass Index Better Identifies Metabolic Syndrome: Insights from Patients in Early Outpatient Cardiac Rehabilitation Open
Body mass index (BMI) does not differentiate fat and lean mass or the distribution of adipose tissue. The purpose of this study was to examine the prevalence of metabolic syndrome (MetS) among patients entering outpatient cardiac rehabilit…
View article: The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction
The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction Open
Aims Increases in extravascular lung water (EVLW) during exercise contribute to symptoms, morbidity, and mortality in patients with heart failure and preserved ejection fraction (HFpEF), but the mechanisms leading to pulmonary congestion d…
View article: The β-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure With Preserved Ejection Fraction
The β-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure With Preserved Ejection Fraction Open
Rationale: Pulmonary vascular resistance fails to decrease appropriately during exercise in patients with heart failure with preserved ejection fraction (HFpEF). Interventions that enhance pulmonary vasodilation might be beneficial in this…
View article: Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex
Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex Open
In this review, we highlight the underlying mechanisms responsible for the sex differences in the exercise pressor reflex (EPR), and, importantly, the impact of sex hormones and menopausal status. The EPR is attenuated in premenopausal wom…
View article: Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction
Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction Open
Rationale: Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but i…