Explanipedia

Relative biodistribution and accumulation of carbonaceous nanoparticles inside the murine and human kidney Open

Leen Rasking, Kenneth Vanbrabant, Maartje Vangeneugden, Thessa Van Pee, Flemming R. Cassee , et al. · 2025

Primary FSGS is not associated with worse kidney outcome compared with other FSGS subtypes Open

Dries Deleersnijder, Evert Cleenders, Maarten Coemans, Amélie Dendooven, Priyanka Koshy , et al. · 2025

Background Studies that compare kidney outcomes across patients with different forms of focal segmental glomerulosclerosis (FSGS) are lacking. Methods This retrospective study compared annual estimated glomerular filtration rate (eGFR) slo…

Newborn glomerular function and gestational particulate air pollution Open

Leen Rasking, Thessa Van Pee, Maartje Vangeneugden, Eleni Renaers, Congrong Wang , et al. · 2024

Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial Open

Katherine R. Tuttle, Sibylle J. Hauske, María Eugênia Fernandes Canziani, Maria Luiza Caramori, David Z.I. Cherney , et al. · 2023

Table of Contents Open

Kyung S. Lee, John Cijiang He, T. Alp İkizler, Clarkson Crane, Pranav S. Garimella , et al. · 2023

Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study Open

Elisabet Van Loon, Claire Tinel, Henriëtte de Loor, Xavier Bossuyt, Jasper Callemeyn , et al. · 2023

Urinary chemokines CXCL9 and CXCL10 have been suggested to be good noninvasive biomarkers of kidney transplant rejection. However, defining a context of use and integration with clinical information is necessary before clinical implementat…

An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma Open

Evert Cleenders, Priyanka Koshy, Elisabet Van Loon, Katrien Lagrou, Kurt Beuselinck , et al. · 2023

Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection Open

Baptiste Lamarthée, Jasper Callemeyn, Yannick Van Herck, Asier Antoranz, Dany Anglicheau , et al. · 2023

Ambient black carbon reaches the kidneys Open

Leen Rasking, Priyanka Koshy, Eva Bongaerts, Hannelore Bové, Marcel Ameloot , et al. · 2023

Lupus, DNA Methylation, and Air Pollution: A Malicious Triad Open

Leen Rasking, Céline Roelens, Ben Sprangers, Bernard Thienpont, Tim S. Nawrot , et al. · 2022

The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day; however, genetic, epigenetic, and environmental factors have been implicated to be involved in disease pathogenesis. Recently, it was demonstrated that in …

Data-Driven Chronic Allograft Phenotypes: A Novel and Validated Complement for Histologic Assessment of Kidney Transplant Biopsies Open

Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Priyanka Koshy, Evelyne Lerut , et al. · 2022

Background No validated system currently exists to realistically characterize the chronic pathology of kidney transplants that represents the dynamic disease process and spectrum of disease severity. We sought to develop and validate a too…

Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection Open

Baptiste Lamarthée, Jasper Callemeyn, Yannick Van Herck, Asier Antoranz, Dany Anglicheau , et al. · 2022

Rejection remains the main cause of premature graft loss after kidney transplantation, despite the use of potent immunosuppression. This highlights the need to better understand the composition and the interactions of the alloreactive infl…

Adverse Effects of fine particulate matter on human kidney functioning: a systematic review Open

Leen Rasking, Kenneth Vanbrabant, Hannelore Bové, Michelle Plusquin, Katrien De Vusser , et al. · 2022

Prevalence, progression and implications of breast artery calcification in patients with chronic kidney disease Open

Brecht Van Berkel, Chantal Van Ongeval, Amaryllis H. Van Craenenbroeck, Hans Pottel, Katrien De Vusser , et al. · 2021

Breast arterial calcification (BAC) is increasingly recognized as a specific marker of medial calcification. The present retrospective observational cohort study aimed to define the prevalence, progression rate, risk factors and clinical i…

Delayed diagnosis and treatment of extreme hypertriglyceridemia due to rejection of a lipemic sample Open

Jan Van Elslande, Michel R. Langlois, Pieter Vermeersch, Glynis Frans, Bart Van der Schueren , et al. · 2021

Most laboratories routinely determine haemolysis, icterus and lipemia indices to identify lipemic samples and reject potentially affected results. Hypertriglyceridemia is the most common cause of lipemia and severe hypertriglyceridemia (≥ …

Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Clustering Open

Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Evelyne Lerut, Aleksandar Senev , et al. · 2021

Significance Statement The current Banff classification of kidney transplant rejection is on the basis of complex and discretionary combinations of histologic scores. As a purely empiric classification, it was not primarily developed to re…

Strategies for asymmetrical triacetate dialyser heparin-free effective haemodialysis: the SAFE study Open

Ines Vandenbosch, Sander Dejongh, Kathleen Claes, Bert Bammens, Katrien De Vusser , et al. · 2020

Background In haemodialysis, maintaining patency of the extracorporeal circuit requires the use of anticoagulants. Although (low molecular weight) heparins are the mainstay, these are not well tolerated in all patients. Alternative approac…

The Histological Picture of Indication Biopsies in the First 2 Weeks after Kidney Transplantation Open

Elisabet Van Loon, Evelyne Lerut, Aleksandar Senev, Maarten Coemans, Jacques Pirenne , et al. · 2020

Background and objectives In preclinical studies, ischemia-reperfusion injury and older donor age are associated with graft inflammation in the early phase after transplantation. In human kidney transplantation, impaired allograft function…

P1064HEPARIN-FREE DIALYSIS: A PHASE II PILOT STUDY USING ASYMMETRIC TRIACETATE (ATA) CELLULOSE DIALYZERS Open

Björn Meijers, Ines Vandenbosch, Bert Bammens, Katrien De Vusser, Amaryllis H. Van Craenenbroeck , et al. · 2020

Background and Aims Not all dialysis patients tolerate heparin anticoagulation. Heparin should be avoided in patients at high risk of bleeding. Strategies include saline infusion, citrate-containing dialysate, regional citrate anticoagulat…

Intrarenal arteriosclerosis and telomere attrition associate with dysregulation of the cholesterol pathway Open

Katrien De Vusser, Ellen Winckelmans, Dries S. Martens, Evelyne Lerut, Dirk Kuypers , et al. · 2020

This study included a test cohort of 40 consecutive kidney donors (calendar age 48.0 ± 15), with biopsies obtained prior to transplantation. Intrarenal leucocyte telomere length content was assessed using quantitative RT-PCR. Whole genome …

Telomere length, cardiovascular risk and arteriosclerosis in human kidneys: an observational cohort study Open

Katrien De Vusser, Nicky Pieters, Bram G. Janssen, Evelyne Lerut, Dirk Kuypers , et al. · 2015

We demonstrate that arteriosclerosis in smaller intrarenal arteries is associated with shorter telomere length. Our study suggests a central role of replicative senescence in the progression of renovascular disease, independent of calendar…

RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection Open

Lucas Van Aelst, Georg Summer, Shengqiao Li, Shashi Kumar Gupta, Ward Heggermont , et al. · 2015

SaO018MITOCHONDRIAL FEEDBACK IS A KEY FEATURE OF KIDNEY GRAFT SENESCENCE Open

Katrien De Vusser, Kevin Hochstenbach, Ellen Winckelmans, Evelyne Lerut, Dirk Kuypers , et al. · 2015

[De Vusser, Katrien; Lerut, Evelyne; Kuypers, Dirk; Naesens, Maarten] UZ Leuven, Leuven, Belgium. [Hochstenbach, Kevin; Winckelmans, Ellen; Nawrot, Tim] Univ Hasselt, Hasselt, Belgium.

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