Katrin Amunts
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View article: From fibers to cells: Fourier-based registration enables virtual Cresyl violet staining from 3D polarized light imaging
From fibers to cells: Fourier-based registration enables virtual Cresyl violet staining from 3D polarized light imaging Open
Comprehensive assessment of the various aspects of the brain’s microstructure requires the use of complementary imaging techniques. This includes measuring the spatial distribution of cell bodies (cytoarchitecture) and nerve fibers (myeloa…
View article: Micron-resolution fiber mapping in histology independent of sample preparation
Micron-resolution fiber mapping in histology independent of sample preparation Open
Mapping the brain’s fiber network is crucial for understanding its function and malfunction, but resolving nerve trajectories over large fields of view is challenging. Here, we show that computational scattered light imaging (ComSLI) can m…
View article: Adult Striatal Neurogenesis—A Comparative Approach Between Pigeons, Mice, Macaques, and Human
Adult Striatal Neurogenesis—A Comparative Approach Between Pigeons, Mice, Macaques, and Human Open
Adult neurogenesis describes the formation of new neurons in the adult brain, a process that is fundamental to related functions, particularly in the hippocampus. Although studies reported adult striatal neurogenesis in humans, the phenome…
View article: HippoMaps: multiscale cartography of human hippocampal organization
HippoMaps: multiscale cartography of human hippocampal organization Open
The hippocampus has a specialized microarchitecture, is situated at the nexus of multiple macroscale functional networks, contributes to numerous cognitive as well as affective processes and is highly susceptible to brain pathology across …
View article: The Vogt Collection: reactivating a treasure facilitating brain research, neurology and psychiatry
The Vogt Collection: reactivating a treasure facilitating brain research, neurology and psychiatry Open
Over 125 years ago, Cécile and Oskar Vogt began assembling an extensive collection of brain histological sections and related documents. Katrin Amunts explains how digitizing these materials will connect them with modern neuroscience, crea…
View article: Pioneers of modern brain research—Cécile and Oskar Vogt and the Nobel Prize
Pioneers of modern brain research—Cécile and Oskar Vogt and the Nobel Prize Open
This article explores the complex and ultimately unsuccessful Nobel Prize trajectories of Oskar (1870–1959) and Cécile Vogt (1875–1962), as well as their ongoing scientific legacy. Their legacy sheds light on the background to the decision…
View article: Three‐Week Video‐ and Home‐Based Training Program for People with Ataxia: A Pilot Randomized Controlled Trial
Three‐Week Video‐ and Home‐Based Training Program for People with Ataxia: A Pilot Randomized Controlled Trial Open
Background Gait and balance impairment is a disabling clinical feature in people with degenerative cerebellar ataxia. Objectives We performed a rater‐blinded, parallel 3‐arm randomized controlled trial with delayed‐start‐design (explorator…
View article: Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains—A Comparative Autoradiographic Study
Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains—A Comparative Autoradiographic Study Open
Serotonergic neurotransmission is crucial for emotion processing and is dysregulated in mood disorders. To analyze the pathophysiology of disease and develop effective pharmacological treatments, the suitability of the rat as a model for t…
View article: Scattering polarimetry enables correlative nerve fiber imaging and multimodal analysis.
Scattering polarimetry enables correlative nerve fiber imaging and multimodal analysis. Open
Mapping the intricate network of nerve fibers is crucial for understanding brain function. Three-Dimensional Polarized Light Imaging (3D-PLI) and Computational Scattered Light Imaging (ComSLI) map dense nerve fibers in brain sections with …
View article: Associations of brain structure with psychopathy
Associations of brain structure with psychopathy Open
Psychopathy is one of the greatest risk factors for serious and persistent violence. In order to detect its neurobiological substrates, we examined 39 male psychopathic subjects and matched controls using structural MR imaging and the Psyc…
View article: Exploring the 3D Architecture of Brain Tissue Using Digital Holographic Microscopy
Exploring the 3D Architecture of Brain Tissue Using Digital Holographic Microscopy Open
A deeper understanding of the complexity of the (human) brain requires the study of its microscopic architecture of neurons and their densely packed networks of nerve fibers. Microscopic techniques based on histological sectioning and stai…
View article: Siibra: A software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources
Siibra: A software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources Open
Computational technology opens new possibilities towards understanding the complexity of the human brain, but it requires integrating measurements from different modalities and scales in anatomical context and exposing them in interoperabl…
View article: Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution <i>in vivo</i> MRI from the Hippocampal Subfields Group (HSG)
Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution <i>in vivo</i> MRI from the Hippocampal Subfields Group (HSG) Open
Hippocampal subfields differentially develop and age, and they vary in vulnerability to neurodegenerative diseases. Innovation in high-resolution imaging has accelerated clinical research on human hippocampal subfields, but substantial dif…
View article: Multimodal gradients unify local and global cortical organization
Multimodal gradients unify local and global cortical organization Open
Functional specialization of brain areas and subregions, as well as their integration into large-scale networks, are key principles in neuroscience. Consolidating both local and global perspectives on cortical organization, however, remain…
View article: The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow
The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow Open
The default mode network (DMN) is implicated in many aspects of complex thought and behavior. Here, we leverage postmortem histology and in vivo neuroimaging to characterize the anatomy of the DMN to better understand its role in informati…
View article: Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories Open
The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed…
View article: Sensor-Based Gait and Balance Assessment in Healthy Adults: Analysis of Short-Term Training and Sensor Placement Effects
Sensor-Based Gait and Balance Assessment in Healthy Adults: Analysis of Short-Term Training and Sensor Placement Effects Open
While the analysis of gait and balance can be an important indicator of age- or disease-related changes, it remains unclear if repeated performance of gait and balance tests in healthy adults leads to habituation effects, if short-term gai…
View article: Differently increased volumes of multiple brain areas in Npc1 mutant mice following various drug treatments
Differently increased volumes of multiple brain areas in Npc1 mutant mice following various drug treatments Open
Background Niemann-Pick disease type C1 (NPC1, MIM 257220) is a heritable lysosomal storage disease characterized by a progressive neurological degeneration that causes disability and premature death. A murine model of Npc1 −/− displays a …
View article: Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain
Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain Open
Neurotransmitter receptor densities are relevant for understanding the molecular architecture of brain regions. Quantitative in vitro receptor autoradiography, has been introduced to map neurotransmitter receptor distributions of brain are…
View article: Multimodal mapping of macaque monkey somatosensory cortex
Multimodal mapping of macaque monkey somatosensory cortex Open
The somatosensory cortex is a brain region responsible for receiving and processing sensory information from across the body and is structurally and functionally heterogeneous. Since the chemoarchitectonic segregation of the cerebral corte…