Katrin Arnold
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Artificial selection for resistance to copper and off-target physiological and behavioral effects in <i>Drosophila melanogaster</i> Open
Pollution resulting from mining, industry, and agriculture has played an important role in shaping the evolution of diverse organisms. The pathway to evolved resistance can involve polygenic shifts that affect multiple traits. Heavy metal …
Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma (HNSCC) Open
Head and neck squamous cell carcinomas (HNSCCs) are the seventh most common form of cancer worldwide, typically characterized by high mortality and significant morbidity, including pain and speech and swallowing disorders. Complete tumor t…
Independent Use of a Home-Based Telemonitoring App by Older Patients With Multimorbidity and Mild Cognitive Impairment: Qualitative Study Open
Background The management of multimorbidity is complex and patients have a high burden of disease. When symptoms of dementia also appear, it becomes even more difficult for patients to cope with their everyday lives and manage their diseas…
Multiperspective and Multimethod Evaluation of Flexible and Integrative Psychiatric Care Models in Germany: Study Protocol of a Prospective, Controlled Multicenter Observational Study (PsychCare) Open
Background: New cross-sectoral mental health care models have been initiated in Germany to overcome the fragmentation of the German health care system. Starting in 2013, flexible and integrative psychiatric care model projects according to…
International experiences in the development and implementation of guideline-based quality indicators: a qualitative study Open
Objectives Evidence-based clinical guidelines play an important role in healthcare and can be a valuable source for quality indicators (QIs). However, the link between guidelines and QI is often neglected and methodological standards for t…
Individual-Level Linkage of Primary and Secondary Data from Three Sources for Comprehensive Analyses of Low Birthweight Effects Open
Aim of the study The linkage of primary and secondary data is becoming an increasingly popular approach in healthcare research, but involves some challenges for all involved parties, for example due to data protection requirements. The aim…
Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease Open
Intrastriatal administration of mesenchymal stem cells (MSCs) has shown beneficial effects in rodent models of Huntington disease (HD). However, the invasive nature of surgical procedure and its potential to trigger the host immune respons…
Impact of birthweight on health-care utilization during early childhood – a birth cohort study Open
This large population-based birth-cohort study indicates a high clinical and economic burden of low birthweight which is not restricted to the first year of life.
I22 Intranasal administration of mesenchymal stem cells ameliorates the abnormal dopamine transmission system and inflammatory reaction in the R6/2 mouse model of huntington disease Open
This is an abstract of a conference paper. It was accepted for publication in Journal of Neurology Neurosurgery and Psychiatry and the definitive final version can be found at https://doi.org/10.1136/jnnp-2018-EHDN.258
The influence of cross-sectoral treatment models on patients with mental disorders in Germany: study protocol of a nationwide long-term evaluation study (EVA64) Open
This study was registered in the database "Health Services Research Germany" (trial number: VVfD_EVA64_15_003713 ).
Helping Alliance and Unmet Needs in Routine Care of People With Severe Mental Illness Across Europe Open
The helping alliance (HA) refers to the collaborative bond between patient and therapist, including shared goals and tasks. People with severe mental illness have a complex mixture of clinical and social needs. Using mixed-effects regressi…
Sox2 Suppresses Gastric Tumorigenesis in Mice Open
Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that t…
Effectiveness of interventions for adults with mild to moderate intellectual disabilities and mental health problems: systematic review and meta-analysis Open
Background There is a lack of available evidence in relation to the effectiveness of interventions for adults with mild to moderate intellectual disability and mental health problems. Aims To evaluate the efficacy of interventions for adul…
The stroke east <span>S</span>axony pilot project for organized post‐stroke care: a case–control study Open
Background Low adherence to secondary prevention guidelines in stroke survivors may increase the risk for recurrent stroke and adversely impact quality of life. We aimed to determine the feasibility of a self‐developed standardized post‐st…