Kathrin Koch
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View article: Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium
Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is a chronic condition in which impaired inhibitory control and excessive error monitoring may contribute to the maintenance of obsessions and compulsions. This mega-analysis investigates neura…
View article: Test-retest reproducibility of structural and proxy estimates of brain connectivity at rest
Test-retest reproducibility of structural and proxy estimates of brain connectivity at rest Open
While structural connectivity (SC) reflects actual neural connections, proxy estimates of brain connectivity such as functional connectivity (FC) from functional MRI, intersubject covariance of regional gray matter volume (GMVcov) from str…
View article: Neural correlates of human fear conditioning and sources of variability in 2199 individuals
Neural correlates of human fear conditioning and sources of variability in 2199 individuals Open
Pavlovian fear conditioning is a fundamental process in both health and disease. We investigated its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2,199 individuals across nin…
View article: Altered model-based prediction error signaling in the lateral orbitofrontal cortex in patients with obsessive-compulsive disorder: An fMRI study
Altered model-based prediction error signaling in the lateral orbitofrontal cortex in patients with obsessive-compulsive disorder: An fMRI study Open
These findings support the notion that OCD is associated with an altered goal-directed system, which may be expressed through increased activation in the lateral OFC activity underlying goal-directed behavior. Importantly, the hyperactivit…
View article: Mindfulness training decreases the habituation response to persistent food stimulation
Mindfulness training decreases the habituation response to persistent food stimulation Open
Modern societies and their obesogenic environments expose individuals to persistent food stimulation. This frequent exposure can cause sensory systems to habituate or desensitize to food-related sensory stimulation. This can, in turn, lead…
View article: Decoding Obsessive-Compulsive Disorder: The Regional Vulnerability Index and Its Association With Clinical Symptoms
Decoding Obsessive-Compulsive Disorder: The Regional Vulnerability Index and Its Association With Clinical Symptoms Open
The current results suggest that the RVI may represent an individual characteristic that reflects the degree of correspondence between individual patterns of structural alterations and disease-characteristic patterns of structural alterati…
View article: Local effective connectivity changes after transcranial direct current stimulation in obsessive-compulsive disorder patients
Local effective connectivity changes after transcranial direct current stimulation in obsessive-compulsive disorder patients Open
We used a single tDCS session, which may not reflect long-term effects.
View article: Exploring connectivity and volume alterations in the Pulvinar’s subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD)
Exploring connectivity and volume alterations in the Pulvinar’s subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD) Open
Background Previous research has highlighted abnormalities in the pulvinar region of the brain among individuals diagnosed with obsessive-compulsive disorder (OCD). Nevertheless, given the pulvinar’s complex structure, comprising four dist…
View article: Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making
Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making Open
Background Decision-making alterations are present in psychiatric illnesses like major depressive disorder (MDD), obsessive–compulsive disorder (OCD), and schizophrenia, linked to symptoms of the respective disorders. We sought to analyze …
View article: Percent amplitude of fluctuations demonstrates altered brain activity in patients with Obsessive-Compulsive Disorder
Percent amplitude of fluctuations demonstrates altered brain activity in patients with Obsessive-Compulsive Disorder Open
Resting state fMRI (rs-fMRI) Studies have shown that patients with obsessive-compulsive disorder (OCD) exhibit alterations in cortical excitability and neuronal synchronisation. Amplitude of low frequency fluctuations (ALFF) is a measure u…
View article: Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks
Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks Open
Cognitive deficits are prevalent in individuals with psychosis and are associated with neurobiological changes, potentially serving as an endophenotype for psychosis. Using the HCP-Early-Psychosis-dataset (n = 226), we aimed to investigate…
View article: Altered model-based prediction error signaling in the lateral orbitofrontal cortex in patients with obsessive-compulsive disorder: An fMRI study
Altered model-based prediction error signaling in the lateral orbitofrontal cortex in patients with obsessive-compulsive disorder: An fMRI study Open
Background Compared to healthy individuals, patients with obsessive-compulsive disorder (OCD) are found to rely more on model-free decision-making strategies which may underlie symptom expression. It is, however, unclear whether these beha…
View article: Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders
Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders Open
Growing evidence supports the effectiveness of deep brain stimulation (DBS) in treating various psychiatric disorders. DBS has the potential to selectively stimulate specific subcortical brain areas thus providing high-frequency electric s…
View article: Mindfulness training reduces the preference for sustainable outcomes
Mindfulness training reduces the preference for sustainable outcomes Open
Theoretical accounts posit that mindfulness promotes pro-environmental behavior. While this claim is supported by correlational findings, past intervention studies provided no evidence that enhancing mindfulness increases self-report measu…
View article: Investigating the effects of brain stimulation on the neural substrates of inhibition in patients with OCD: A simultaneous tDCS – fMRI study
Investigating the effects of brain stimulation on the neural substrates of inhibition in patients with OCD: A simultaneous tDCS – fMRI study Open
Inhibition deficits constitute a core characteristic of obsessive-compulsive disorder (OCD). There is evidence in healthy individuals that transcranial direct current stimulation (tDCS) of the pre-supplementary motor area (pre-SMA) leads t…
View article: Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making
Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making Open
Background: Decision-making alterations are present in psychiatric illnesses like major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia, linked to symptoms of the respective disorders. Understanding unique…
View article: Similarity between structural and proxy estimates of brain connectivity
Similarity between structural and proxy estimates of brain connectivity Open
Functional magnetic resonance and diffusion weighted imaging have so far made a major contribution to delineation of the brain connectome at the macroscale. While functional connectivity (FC) was shown to be related to structural connectiv…
View article: Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium Open
Correction to: Molecular Psychiatry, published online 2 May 2023 In this article Honami Arai, Irene Bollettini, Rosa Calvo Escalona, Ana Coelho, Federica Colombo, Leila Darwich, Martine Fontaine, Toshikazu Ikuta, Jonathan C. Ipser, Asier J…
View article: White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group
White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group Open
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies…
View article: A multicentre study on grey matter morphometric biomarkers for classifying early schizophrenia and parkinson’s disease psychosis
A multicentre study on grey matter morphometric biomarkers for classifying early schizophrenia and parkinson’s disease psychosis Open
Psychotic symptoms occur in a majority of schizophrenia patients and in ~50% of all Parkinson’s disease (PD) patients. Altered grey matter (GM) structure within several brain areas and networks may contribute to their pathogenesis. Little …