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View article: Microbiome dynamics in the congregate environment of U.S. Army Infantry training
Microbiome dynamics in the congregate environment of U.S. Army Infantry training Open
Within military training and operational environments, individuals from diverse backgrounds share common spaces, follow structured routines and diets, and engage in physically demanding tasks. While there has been interest in leveraging mi…
View article: Clinical, Radiographic, and Physiological Correlates of Post-COVID-19 Dyspnea in Military Health System Beneficiaries: Results From the Chronic Impairment With Pulmonary Symptoms (ChIPS) Sub-study
Clinical, Radiographic, and Physiological Correlates of Post-COVID-19 Dyspnea in Military Health System Beneficiaries: Results From the Chronic Impairment With Pulmonary Symptoms (ChIPS) Sub-study Open
Background Dyspnea has been described in up to 10–30% of patients post-SARS-CoV-2 infection. The underlying pathology for these persistent symptoms remains poorly understood. This study aimed to characterize changes in cardiopulmonary anat…
View article: Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease
Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease Open
Introduction T cells influence COVID-19 severity and establish long-lasting immune memory in response to vaccination and infection. The diversity of the T cell repertoire, and complexity of T cell epitope recognition, make it challenging t…
View article: Randomized Pragmatic Trial of the Comparative Effectiveness of Chicken Egg-Based Inactivated, Mammalian Cell Culture-Based Inactivated, and Recombinant Protein Quadrivalent Seasonal Influenza Vaccines in United States Military Health System Beneficiaries
Randomized Pragmatic Trial of the Comparative Effectiveness of Chicken Egg-Based Inactivated, Mammalian Cell Culture-Based Inactivated, and Recombinant Protein Quadrivalent Seasonal Influenza Vaccines in United States Military Health System Beneficiaries Open
Background Influenza is a major cause of morbidity and mortality worldwide. The Pragmatic Assessment of Influenza Vaccine Effectiveness (VE) in the Department of Defense (PAIVED) study compared the relative VE (rVE) of 2 licensed influenza…
View article: The infectious diseases clinical research program acute respiratory infection repository protocol: Opportunities to understand current and future epidemics
The infectious diseases clinical research program acute respiratory infection repository protocol: Opportunities to understand current and future epidemics Open
Background Acute respiratory infections (ARI) are a major cause of morbidity and lost workdays in both military and non-military populations. To better understand these infections and their outcomes, the Infectious Diseases Clinical Resear…
View article: Evaluation of Department of Defense hospital antimicrobial stewardship programs (ASPs) using a novel Core Elements scoring approach and modeling Core Elements scores with metrics related to ASP outcomes
Evaluation of Department of Defense hospital antimicrobial stewardship programs (ASPs) using a novel Core Elements scoring approach and modeling Core Elements scores with metrics related to ASP outcomes Open
Objective: Evaluate Department of Defense (DoD) antimicrobial stewardship programs (ASPs) by assessing the relationship between key clinical outcome metrics (antibiotic use, incidence of resistant pathogens, and incidence of Clostridioides…
View article: Antiretroviral Therapy Within 2 Years of HIV Acquisition Is Associated With Fewer Viral Blips: A Retrospective Analysis of More Than 20 Years of Data From the US Military HIV Natural History Study
Antiretroviral Therapy Within 2 Years of HIV Acquisition Is Associated With Fewer Viral Blips: A Retrospective Analysis of More Than 20 Years of Data From the US Military HIV Natural History Study Open
Background Viral blips have been associated with larger reservoir size and slower decay. Earlier antiretroviral therapy (ART) initiation may decrease the risk of blips. Methods We analyzed participants from the US Military HIV Natural Hist…
View article: Demographics, epidemiology, mortality and difficult-to-treat resistance patterns of bacterial bloodstream infections in the global US Military Health System from 2010 to 2019: a retrospective cohort study
Demographics, epidemiology, mortality and difficult-to-treat resistance patterns of bacterial bloodstream infections in the global US Military Health System from 2010 to 2019: a retrospective cohort study Open
Objective To describe demographics, causative pathogens, hospitalisation, mortality and antimicrobial resistance (AMR) of bacterial bloodstream infections (BSIs) among beneficiaries in the global US Military Health System (MHS), a single-p…
View article: P-1936. Does SARS-CoV-2 Infection or Vaccination Impact Menstrual Health? Results From a Longitudinal Cohort Study Among Military Health System Beneficiaries
P-1936. Does SARS-CoV-2 Infection or Vaccination Impact Menstrual Health? Results From a Longitudinal Cohort Study Among Military Health System Beneficiaries Open
Background The impact of SARS-CoV-2 infection and vaccination on menstruation is unclear. The goal of this study is to quantify the relationships between history of SARS-CoV-2 vaccination and infection and incident, clinically documented m…
View article: P-725. Incidence and Severity of Influenza-like Illness in Cigarette Users: A Prospective Study
P-725. Incidence and Severity of Influenza-like Illness in Cigarette Users: A Prospective Study Open
Background Influenza-like illness (ILI) causes significant morbidity. This study aims to compare ILI incidence and severity of current tobacco smokers, former smokers, and non-smokers enrolled in a randomized clinical trial, comparing infl…
View article: P-2125. Evaluation of MucorGenius® Mucorales Real-Time PCR Assay with Formalin-Fixed Paraffin-Embedded Tissue Specimens
P-2125. Evaluation of MucorGenius® Mucorales Real-Time PCR Assay with Formalin-Fixed Paraffin-Embedded Tissue Specimens Open
Background Early identification of mucormycetes in trauma-related invasive fungal wound infections (IFI) improves outcomes. A commercially available, multiplex, real-time Mucorales assay has the potential to provide results within 3 hours,…
View article: P-745. Skin and Soft-tissue Infections among Military Recruits
P-745. Skin and Soft-tissue Infections among Military Recruits Open
Background Skin and soft-tissue infections (SSTIs), commonly Staphylococcus aureus, are an important cause of morbidity in congregate military populations with high rates among military recruits. We characterized SSTI epidemiology over an …
View article: P-742. Characterization of the Inoculum Effect in Battlefield Trauma Patients with Methicillin-Susceptible <i>Staphylococcus aureus</i> Infections
P-742. Characterization of the Inoculum Effect in Battlefield Trauma Patients with Methicillin-Susceptible <i>Staphylococcus aureus</i> Infections Open
Background The clinical relevance of the cefazolin inoculum effect (CIE) in methicillin-susceptible Staphylococcus aureus (MSSA) isolates has been debated, with some studies showing poor outcomes in CIE(+) MSSA patients treated with β-lact…
View article: P-753. Characterizing Multidrug-Resistant <i>Acinetobacter baumannii</i> Infections among Wartime Casualties
P-753. Characterizing Multidrug-Resistant <i>Acinetobacter baumannii</i> Infections among Wartime Casualties Open
Background Acinetobacter baumannii (ACB) emerged as a key pathogen during the war in Iraq and was designated as a serious threat in the 2013 Centers for Disease Control’s antimicrobial resistance report. We describe the characteristics of …
View article: P-1935. Proteomic and transcriptomic signatures of SARS-CoV-2 associated myocarditis
P-1935. Proteomic and transcriptomic signatures of SARS-CoV-2 associated myocarditis Open
Background SARS-CoV-2 myocarditis is a rare but serious complication of COVID-19. The host response correlates of SARS-CoV-2 myocarditis remain unclear, thereby limiting therapeutic development. We therefore performed proteomic and transcr…
View article: P-1980. Decoding the Complexity of Post COVID Conditions: Transcriptomic Analyses of Machine-Learning-Based Chronic Symptom Phenotypes
P-1980. Decoding the Complexity of Post COVID Conditions: Transcriptomic Analyses of Machine-Learning-Based Chronic Symptom Phenotypes Open
Background Post-COVID conditions (PCC, ‘Long COVID’) remain a military health concern, and symptom heterogeneity limits understanding of PCC pathogenesis. To address this, we used machine learning to define PCC phenotypes in Military Healt…
View article: Comparison of neuraminidase inhibiting antibody responses elicited by egg- and cell-derived influenza vaccines
Comparison of neuraminidase inhibiting antibody responses elicited by egg- and cell-derived influenza vaccines Open
Antibody responses to NA following vaccination with eIIV and cIIV were not the same; although the responses to the N1 and N2 components of eIIV were similar, there were fewer responders to N1 than N2 of cIIV. Studies to determine the impac…
View article: Characteristics and framework analysis of Department of Defense hospital Antibiotic Stewardship Programs guided by the Centers for Disease Control and Prevention Core Elements
Characteristics and framework analysis of Department of Defense hospital Antibiotic Stewardship Programs guided by the Centers for Disease Control and Prevention Core Elements Open
Objective: Characterization and assessment of Department of Defense’s (DoD’s) Antibiotic Stewardship Programs (ASPs) to determine adherence to Centers for Disease Control and Prevention (CDC) Core Elements and compare to national adherence…
View article: The Infectious Diseases Clinical Research Program Acute Respiratory Infection Repository Protocol: Opportunities to Understand Current and Future Epidemics
The Infectious Diseases Clinical Research Program Acute Respiratory Infection Repository Protocol: Opportunities to Understand Current and Future Epidemics Open
Background: Acute respiratory infections (ARI) are a major cause of morbidity and lost workdays in both military and non-military populations. To better understand these infections and their outcomes, the Infectious Diseases Clinical Resea…
View article: Demographics, Epidemiology, Mortality, and Difficult-To-Treat Resistance Patterns of Bacterial Bloodstream Infections in the Global United States Military Health System from 2010-2019: A Retrospective Cohort Study
Demographics, Epidemiology, Mortality, and Difficult-To-Treat Resistance Patterns of Bacterial Bloodstream Infections in the Global United States Military Health System from 2010-2019: A Retrospective Cohort Study Open
Objective To describe demographics, causative pathogens, hospitalization, mortality, and antimicrobial resistance of bacterial bloodstream infections (BSIs) among beneficiaries in the global U.S. Military Health System (MHS), a single-prov…
View article: Estimating the Effect of Coronavirus Disease 2019 (COVID-19) Vaccination and Infection Variant on Post-COVID-19 Venous Thrombosis or Embolism Risk
Estimating the Effect of Coronavirus Disease 2019 (COVID-19) Vaccination and Infection Variant on Post-COVID-19 Venous Thrombosis or Embolism Risk Open
Background Previous research has shown that vaccination reduces risk of post–coronavirus disease 2019 (COVID-19) venous thrombosis or embolism (VTE), but the effect of vaccine boosting on post-COVID-19 VTE risk reduction is unclear. We sou…
View article: Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae
Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae Open
Background Post-COVID conditions (PCC) are difficult to characterize, diagnose, predict, and treat due to overlapping symptoms and poorly understood pathology. Identifying inflammatory profiles may improve clinical prognostication and tria…
View article: SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up
SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up Open
Background Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neuropsyc…
View article: A Seminested PCR Method for the Diagnosis of Invasive Fungal Infections in Combat Injured
A Seminested PCR Method for the Diagnosis of Invasive Fungal Infections in Combat Injured Open
Background Among combat injured, invasive fungal infections (IFIs) result in significant morbidity. Cultures and histopathology are the primary diagnostic methods for IFIs, but they have limitations. We previously evaluated a panfungal pol…
View article: SARS-CoV-2 variant replacement constrains vaccine-specific viral diversification
SARS-CoV-2 variant replacement constrains vaccine-specific viral diversification Open
Coronavirus disease 2019 (COVID-19) vaccine breakthrough infections have been important for all circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant periods, but the contribution of vaccine-specific SARS-CoV-2 v…
View article: 1021. Semi-nested Molecular Method for the Diagnosis of Invasive Fungal Infections in Combat Injured
1021. Semi-nested Molecular Method for the Diagnosis of Invasive Fungal Infections in Combat Injured Open
Background Among combat injured, invasive fungal infections (IFI) result in significant morbidity (eg surgical amputations). Primary diagnostic methods are limited as cultures are insensitive and time delayed, and histopathology often cann…
View article: 435. Clinical, Radiographic, and Physiological Correlates of post-COVID-19 Respiratory Symptoms: Results from the Chronic Impairment with Pulmonary Symptoms (ChIPS) Sub-study
435. Clinical, Radiographic, and Physiological Correlates of post-COVID-19 Respiratory Symptoms: Results from the Chronic Impairment with Pulmonary Symptoms (ChIPS) Sub-study Open
Background The pathology of persistent post-COVID-19 symptoms remains poorly understood. We examined radiographic and physiological correlates in those with ongoing post-COVID-19 dyspnea compared to those with resolved dyspnea. Methods The…
View article: 437. Does “Long COVID” Resolve by One Year in U.S. Military Health System Beneficiaries?
437. Does “Long COVID” Resolve by One Year in U.S. Military Health System Beneficiaries? Open
Background The long-term duration of post COVID condition (PCC, “Long COVID”) remains unclear. In this study, we estimated the risk of healthcare encounters in Military Health System (MHS) beneficiaries for the 12 months post SARS-CoV-2 di…