Werner Müller
YOU?
Author Swipe
Glass-like Carbon in the Nalbach/Saarlouis (Saarland, Germany) Proposed Touchdown Airburst Impact Event: Evidence of Shock Metamorphism of Organic Material Open
The Nalbach/Saarlouis (Saarland, Germany) meteorite impact strewn field has been established by two impact craters and larger clusters of smaller craters. Intense impact liquefaction features, widespread impact signature of strong shock me…
Spatial protein and RNA analysis on the same tissue section using MICS technology Open
Spatial Biology has evolved from the molecular characterization of microdissected cells to high throughput spatial RNA and protein expression analysis at scale. The main limitation of spatial technologies so far is the inability to resolve…
OMAP-10: Multiplexed Antibody-Based Imaging of Human Palatine Tonsil with MACSima v1.0 Open
OMAP-10 was designed for MACSima (MACSima imaging cyclic staining) imaging of paraformaldehyde (PFA)-fixed human tonsil samples. The MACSima technology is described in detail in the following publication (https://doi.org/10.1038/s41598-022…
OMAP-10: Multiplexed Antibody-Based Imaging of Human Palatine Tonsil with MACSima v1.0 Open
OMAP-10 was designed for MACSima (MACSima imaging cyclic staining) imaging of paraformaldehyde (PFA)-fixed human tonsil samples. The MACSima technology is described in detail in the following publication (https://doi.org/10.1038/s41598-022…
View article: Figure S1 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Figure S1 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Efficient inactivation of RNase H2 in the epidermis, and skin phenotype of Rnaseh2EKO mice.
View article: Figure S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Figure S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Spontaneous type I IFN response and inflammation in Rnaseh2EKO skin.
View article: Figure S3 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Figure S3 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Spontaneous DNA damage response and neoplastic ulcerations in Rnaseh2EKO mice.
View article: Data from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Data from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Because of imperfect discrimination against ribonucleoside triphosphates by the replicative DNA polymerases, large numbers of ribonucleotides are incorporated into the eukaryotic nuclear genome during S-phase. Ribonucleotides, by far the m…
View article: Figure S1 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Figure S1 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Efficient inactivation of RNase H2 in the epidermis, and skin phenotype of Rnaseh2EKO mice.
View article: Data from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Data from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Because of imperfect discrimination against ribonucleoside triphosphates by the replicative DNA polymerases, large numbers of ribonucleotides are incorporated into the eukaryotic nuclear genome during S-phase. Ribonucleotides, by far the m…
View article: Table S1 and S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Table S1 and S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
This file contains transcripts induced by type I interferon (S1) or regulated by p53 in response to DNA damage (S2).
Figure S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Spontaneous type I IFN response and inflammation in Rnaseh2EKO skin.
Figure S3 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Spontaneous DNA damage response and neoplastic ulcerations in Rnaseh2EKO mice.
Figure S4 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Influence of p53-deficiency on phenotype of Rnaseh2EKO mice.
Figure S4 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Influence of p53-deficiency on phenotype of Rnaseh2EKO mice.
Table S3-S6 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
This file contains histology of skin and skin lesions of RNaseH2EKO mice with intact or defective Trp53 alleles.
Supplementary Information from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Histopathological characterization of mutant skin
Table S3-S6 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
This file contains histology of skin and skin lesions of RNaseH2EKO mice with intact or defective Trp53 alleles.
Supplementary Information from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
Histopathological characterization of mutant skin
Table S1 and S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Open
This file contains transcripts induced by type I interferon (S1) or regulated by p53 in response to DNA damage (S2).
Active Discrimination Learning for Gaussian Process Models Open
The paper covers the design and analysis of experiments to discriminate between two Gaussian process models, such as those widely used in computer experiments, kriging, sensor location and machine learning. Two frameworks are considered. F…
Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation Open
Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonst…
Genetic diversity of honeybee colonies predicts gut bacterial diversity of individual colony members Open
Summary The gut microbiota of social bees is relatively simple and dominated by a set of core taxa found consistently in individuals around the world. Yet, variation remains and can affect host health. We characterized individual‐ and regi…
View article: <i>Nfkb2</i> deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa
<i>Nfkb2</i> deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa Open
Novel transcriptomic analysis of murine proximal intestinal mucosa revealed an unexpected B cell signature in Nfkb2 −/− mice. In-depth analysis revealed a defect in the CD38+ B cell population and a gut-specific dysregulation of immunoglob…
Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation Open
Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon induced JAK-STAT signalling in innate immune macrophages. We demonst…
View article: A kinase-dead <i>Csf1r</i> mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling
A kinase-dead <i>Csf1r</i> mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling Open
Amino acid substitutions in the kinase domain of the human CSF1R gene are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human disease, we created a disease-…
View article: Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses
Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses Open
The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP trans…