Katrin Peter
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Impact of Liver and Kidney Function on Vitamin D3 Metabolism in Female and Male Patients Undergoing Allogeneic Hematopoietic Stem-Cell Transplantation Open
We previously described that elevated levels of the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) during the early phase of allogeneic hematopoietic stem-cell transplantation (HSCT) can predict one-year transplant-rel…
View article: The Tumor Metabolite 5′-Deoxy-5′Methylthioadenosine (MTA) Inhibits Maturation and T Cell-Stimulating Capacity of Dendritic Cells
The Tumor Metabolite 5′-Deoxy-5′Methylthioadenosine (MTA) Inhibits Maturation and T Cell-Stimulating Capacity of Dendritic Cells Open
Metabolite accumulation in the tumor microenvironment fosters immune evasion and limits the efficiency of immunotherapeutic approaches. Methylthioadenosine phosphorylase (MTAP), which catalyzes the degradation of 5′-deoxy-5′methylthioadeno…
View article: Strain specific differences in vitamin D3 response: impact on gut homeostasis
Strain specific differences in vitamin D3 response: impact on gut homeostasis Open
Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome di…
View article: Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibi…
View article: Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibi…
View article: Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary table 1 - Antibodies used for flow cytometry analysis; Supplemenary table 2 - Antibodies used for Western blot analysis; Supplemenary table 3 - Primer and PCR conditions used for MDM4 alternative splicing PCR
View article: Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary table 1 - Antibodies used for flow cytometry analysis; Supplemenary table 2 - Antibodies used for Western blot analysis; Supplemenary table 3 - Primer and PCR conditions used for MDM4 alternative splicing PCR
View article: Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary Figure S1 - Evaluation of the synergistic effect of the PRMT5-inhibiting molecules MTA and EPZ015666; Supplementary Figure S2 - PRMT5 inhibition reduces T-cell proliferation, viability and functionality; Supplementary Figure …
View article: Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary Figure S1 - Evaluation of the synergistic effect of the PRMT5-inhibiting molecules MTA and EPZ015666; Supplementary Figure S2 - PRMT5 inhibition reduces T-cell proliferation, viability and functionality; Supplementary Figure …
Physiological levels of 25‐hydroxyvitamin D<sub>3</sub> induce a suppressive CD4<sup>+</sup> T cell phenotype not reflected in the epigenetic landscape Open
1,25‐dihydroxyvitamin D3 (1,25(OH) 2 D 3 ), the active metabolite of vitamin D3 has a strong impact on the differentiation and function of immune cells. Here we analysed the influence of its precursor 25‐hydroxyvitamin D3 (25(OH)D 3 ) on t…
Anti-Thymocyte Globulin Treatment Augments 1,25-Dihydroxyvitamin D3 Serum Levels in Patients Undergoing Hematopoietic Stem Cell Transplantation Open
Application of anti-thymocyte globulin (ATG) is a widely used strategy for the prevention of graft-versus-host disease (GvHD). As vitamin D3 serum levels are also discussed to affect hematopoietic stem cell transplantation (HSCT) outcome a…
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients Open
Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA …
1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation Open
The serum level of 25-hydroxyvitamin-D3 is accepted as marker for a person’s vitamin D status but its role for the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is controversially discussed. The impact of 1,25-dihydr…
View article: Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibi…
Regulation of the Immune Balance During Allogeneic Hematopoietic Stem Cell Transplantation by Vitamin D Open
One of the most promising therapeutic approaches for numerous hematological malignancies represents the allogeneic hematopoietic stem cell transplantation (allo-HSCT). One major complication is the development of the life-threatening graft…
View article: Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis
Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis Open
Background: Melanoma and squamous cell carcinoma of the skin are characterized by an altered glucose metabolism, but little is known about metabolic changes in precancerous skin lesions such as actinic keratosis (AK). Here, we studied the …
D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells Open
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell d…
Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells Open
The accelerated metabolism of tumor cells, inevitable for maintaining high proliferation rates, is an emerging target for tumor therapy. Increased glucose and lipid metabolism as well as mitochondrial activity have been shown in solid tumo…
View article: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the Open
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, a…
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism Open
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the "Warburg effect" because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, a…
The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation Open
Intestinal microbiota disruption is associated with acute gastrointestinal (GI) Graft-versus-Host Disease (GvHD) and poor outcome after allogeneic stem cell transplantation (ASCT). Here, in a retrospective analysis of 200 patients undergoi…
Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment Open
Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor cells and the number and activity of tumor-infiltrating T cells represent a good marker for tumor prognosis. Based on these findings, immunotherapy,…
Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells Open
Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion …
Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells Open
The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy of cancer. The tumor milieu is among others shaped by tumor metabolites such as 5'-deoxy-5'-methylthioadenosine (MTA). Increased intratumor…