Katrin Roth
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View article: Small-Molecule Activators of PRMT1: Discovery, Optimization, and Proapoptotic Effects in Pancreatic Cancer Cells
Small-Molecule Activators of PRMT1: Discovery, Optimization, and Proapoptotic Effects in Pancreatic Cancer Cells Open
A substantial and growing body of research implicates protein‑arginine methyltransferases (PRMTs) in the pathogenesis of a range of human diseases, most prominently cancer. Their role – as oncoproteins or tumor suppressors – depends on bot…
View article: Protocol for analyzing T cell and macrophage motility in a mouse pancreatic cancer spheroid model using light-sheet microscopy
Protocol for analyzing T cell and macrophage motility in a mouse pancreatic cancer spheroid model using light-sheet microscopy Open
View article: Basal cell adhesion molecule (BCAM) promotes mesothelial-to-mesenchymal transition and tumor angiogenesis through paracrine signaling
Basal cell adhesion molecule (BCAM) promotes mesothelial-to-mesenchymal transition and tumor angiogenesis through paracrine signaling Open
View article: Optimized Spheroid Model of Pancreatic Cancer Demonstrates Influence of Macrophage–T Cell Interaction for Intratumoral T Cell Motility
Optimized Spheroid Model of Pancreatic Cancer Demonstrates Influence of Macrophage–T Cell Interaction for Intratumoral T Cell Motility Open
Background: Most spheroid models use size measurements as a primary readout parameter; some models extend analysis to T cell infiltration or perform caspase activation assays. However, to our knowledge, T cell motility analysis is not regu…
View article: Photon Irradiation Prompts Autophagy in Anaplastic Thyroid Cancer
Photon Irradiation Prompts Autophagy in Anaplastic Thyroid Cancer Open
Although promising results have been obtained for anaplastic thyroid cancer (ATC) therapy, this therapy still needs to be improved. In addition to the currently approved therapies, radiotherapy alone or combined with adjuvant immunotherapy…
View article: Transcriptomic response of prostate cancer cells to carbon ion and photon irradiation with focus on androgen receptor and TP53 signaling
Transcriptomic response of prostate cancer cells to carbon ion and photon irradiation with focus on androgen receptor and TP53 signaling Open
View article: Efficacy and safety of eliapixant in endometriosis-associated pelvic pain: the randomized, placebo-controlled phase 2b SCHUMANN study
Efficacy and safety of eliapixant in endometriosis-associated pelvic pain: the randomized, placebo-controlled phase 2b SCHUMANN study Open
View article: DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer Open
Objective Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant immunosuppressive and fibrotic tumour microenvironment (TME). Future therapeutic attempts will therefore demand the targeting of tumours and…
View article: Patterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin’s lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group
Patterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin’s lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group Open
View article: Evolving trends in the surgical therapy of patients with endometrial cancer in Germany: analysis of a nationwide registry with special emphasis on perioperative outcomes
Evolving trends in the surgical therapy of patients with endometrial cancer in Germany: analysis of a nationwide registry with special emphasis on perioperative outcomes Open
View article: Evolving Trends in the Surgical Therapy of Patients with Endometrial Cancer in Germany: Analysis of a Nationwide Registry with Special Emphasis on Perioperative Outcomes
Evolving Trends in the Surgical Therapy of Patients with Endometrial Cancer in Germany: Analysis of a Nationwide Registry with Special Emphasis on Perioperative Outcomes Open
Purpose Endometrial cancer (EC) is the most common gynecological malignancy in women, with increasing incidence in the last decades. Surgical therapy is the mainstay of the initial management. The present study analyzed the evolving trends…
View article: Generation of a Syngeneic Heterozygous ACVRL1(wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis
Generation of a Syngeneic Heterozygous ACVRL1(wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis Open
Hereditary hemorrhagic telangiectasia (HHT) type 2 is an autosomal dominant disease in which one allele of the ACVRL1 gene is mutated. Patients exhibit disturbances in TGF-beta/BMP-dependent angiogenesis and, clinically, often present with…
View article: IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model
IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model Open
In pancreatic ductal adenocarcinoma (PDAC), the infiltration of CD8+ cytotoxic T cells (CTLs) is an important factor in determining prognosis. The migration pattern and interaction behavior of intratumoral CTLs are pivotal to tumor rejecti…
View article: Basal cell adhesion molecule promotes metastasis‐associated processes in ovarian cancer
Basal cell adhesion molecule promotes metastasis‐associated processes in ovarian cancer Open
Background Basal cell adhesion molecule (BCAM) is a laminin α5 (LAMA5) binding membrane‐bound protein with a putative role in cancer. Besides full‐length BCAM1, an isoform lacking most of the cytoplasmic domain (BCAM2), and a soluble form …
View article: Selected commensals educate the intestinal vascular and immune system for immunocompetence
Selected commensals educate the intestinal vascular and immune system for immunocompetence Open
Background The intestinal microbiota fundamentally guides the development of a normal intestinal physiology, the education, and functioning of the mucosal immune system. The Citrobacter rodentium -carrier model in germ-free (GF) mice is su…
View article: IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity Open
View article: IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired<i>Jak3</i>mutations conferring IL-7 hypersensitivity
IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired<i>Jak3</i>mutations conferring IL-7 hypersensitivity Open
The processes leading from disturbed B cell development to adult B cell progenitor acute lymphoblastic leukemia (BCP-ALL) are poorly understood. Here, we describe Irf4 −/− mice as prone to developing BCP-ALL with age. Irf4 −/− preB-I cells…
View article: Additional file 2 of Selected commensals educate the intestinal vascular and immune system for immunocompetence
Additional file 2 of Selected commensals educate the intestinal vascular and immune system for immunocompetence Open
Additional file 2: Supplemental Table 1. Results of virulence factor and antibiotic resistance gene prediction based on blastp&VFDB and RGI&CARD.
View article: Outcomes of female and male patients suffering from coronary artery disease
Outcomes of female and male patients suffering from coronary artery disease Open
Presentation and mortality of coronary artery disease (CAD) substantially differs in both sexes. Most of the existing data analyzing sex differences is older than 10 years and mostly was retrieved in clinical trials, which are potentially …
View article: Evolving trends in the surgical staging of endometrial cancer patients in Germany: Analysis of a nationwide registry with special emphasis on perioperative outcomes
Evolving trends in the surgical staging of endometrial cancer patients in Germany: Analysis of a nationwide registry with special emphasis on perioperative outcomes Open
Purpose The present study compared the use and outcomes of open surgical staging, laparoscopic surgical staging and robotic-assisted surgical staging in all patients suffering from endometrial carcinoma undergoing surgery in Germany betwee…
View article: Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors
Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors Open
The Warthin tumor represents the second most frequent benign tumor of the parotid gland and is characterized by the presence of oncocytes rich in structurally and functionally altered mitochondria. Next to its role in metabolism, glycerald…
View article: HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA, Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3
HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA, Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3 Open
Receptor specificity of the HA of IAVs is known to be a critical determinant of viral cell tropism. Here, we show that fusion properties of the HA may also play a key role in the tropism. Thus, we demonstrate that IAVs having a relatively …
View article: Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53
Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53 Open
Extracellular vesicles released by tumor cells contribute to the reprogramming of the tumor microenvironment and interfere with hallmarks of cancer including metastasis. Notably, melanoma cell-derived EVs are able to establish a pre-metast…
View article: DYRK1B regulates Hedgehog-induced microtubule acetylation
DYRK1B regulates Hedgehog-induced microtubule acetylation Open
View article: Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with <i>RAS</i>-Mutated Hepatocellular Carcinoma
Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with <i>RAS</i>-Mutated Hepatocellular Carcinoma Open
Purpose: Refametinib, an oral MEK inhibitor, has demonstrated antitumor activity in combination with sorafenib in patients with RAS-mutated hepatocellular carcinoma (HCC). Two phase II studies evaluated the efficacy of refametinib monother…
View article: Glyceraldehyd-3-Phosphat Dehydrogenase (GAPDH) als mögliches Kandidatengen bei der Pathogenese von Zystadenolymphomen der Glandula Parotis
Glyceraldehyd-3-Phosphat Dehydrogenase (GAPDH) als mögliches Kandidatengen bei der Pathogenese von Zystadenolymphomen der Glandula Parotis Open
Zystadenolymphome (ZALs) stellen die zweithäufigsten gutartigen Tumoren der Glandula Parotis dar wobei ihre Pathogenese unklar ist. Sie bestehen aus, in einem lymphozytären Stroma eingebetteten, Onkozyten, welche zahlreiche gealterte Mitoc…
View article: Glyceraldehyde-3-Phosphat Dehydrogenase (GAPDH) as a candidate gene in the pathogenesis of parotid gland cystadenolymphoma
Glyceraldehyde-3-Phosphat Dehydrogenase (GAPDH) as a candidate gene in the pathogenesis of parotid gland cystadenolymphoma Open
Cystadenolymphomas (CALs) represent the second most frequent benign tumors of the parotid gland and are characterized by the presence of onkocytes, embedded in a lymphocyte rich stroma. These onkocytes are found to contain a large number o…
View article: RESPIRE 1: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis
RESPIRE 1: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis Open
We evaluated the efficacy and safety of ciprofloxacin dry powder for inhalation (DPI) in patients with non-cystic fibrosis bronchiectasis, two or more exacerbations in the previous year and pre-defined bacteria in sputum. In this phase III…
View article: RESPIRE 2: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis
RESPIRE 2: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis Open
We evaluated the efficacy and safety of ciprofloxacin dry powder for inhalation (DPI) in patients with non-cystic fibrosis bronchiectasis, two or more exacerbations in the previous year and predefined sputum bacteria. Patients were randomi…
View article: Table of Contents
Table of Contents Open