Katrina A. S. Davis
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View article: Combined family history and polygenic score prediction of major depressive disorder
Combined family history and polygenic score prediction of major depressive disorder Open
Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …
View article: The lack of legacy benefits of low-dose aspirin: the ASPREE study
The lack of legacy benefits of low-dose aspirin: the ASPREE study Open
View article: The UK Biobank mental health enhancement 2022: Methods and results
The UK Biobank mental health enhancement 2022: Methods and results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…
View article: Biodiversity research requires more rotors and wheels on and above ground, as well as below water
Biodiversity research requires more rotors and wheels on and above ground, as well as below water Open
Human activities have caused rapid decline in biodiversity, with accelerating species extinction. Simultaneously, recent advancements in artificial intelligence and autonomous systems offer transformative potential for biodiversity researc…
View article: Unlocking mental health insights with UK Biobank data: Past use and future opportunities
Unlocking mental health insights with UK Biobank data: Past use and future opportunities Open
UK Biobank (UKB) is a large-scale, prospective resource offering significant opportunities for mental health research. Data include genetic and biological data, healthcare linkage, and mental health enhancements. Challenges arise from inco…
View article: The UK Biobank Mental Health Enhancement 2022: Methods and Results
The UK Biobank Mental Health Enhancement 2022: Methods and Results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40-…
View article: The role of UK Biobank in mental health research: a review and commentary
The role of UK Biobank in mental health research: a review and commentary Open
Background: UK Biobank (UKB) is a large-scale, prospective resource including genetic and biological data, healthcare linkage, and mental health enhancements, offering significant opportunities for mental health research. However, challeng…
View article: Characterization of CD4+ t cell subsets during Chlamydia muridarum genital infection
Characterization of CD4+ t cell subsets during Chlamydia muridarum genital infection Open
Characterization of CD4+ T cell subsets in a stressed mouse model during Chlamydia muridarum genital infection. Katrina Davis, Tesfaye Belay. Department of Applied Sciences and Mathematics. Chlamydia genital infection caused by Chlamydia t…
View article: Can medication mentions in CRIS be used for researching medication use in older people with dementia? Comparing the natural language processing app for medicines to GP prescribing
Can medication mentions in CRIS be used for researching medication use in older people with dementia? Comparing the natural language processing app for medicines to GP prescribing Open
Background The efficacy of long-term preventative medication in people who have dementia and other comorbidities is unknown. Electronic health record-based observational studies may play a role in evaluating medicines, and SLaM-CRIS is one…
View article: Indicators of recent COVID-19 infection status: findings from a large occupational cohort of staff and postgraduate research students from a UK university
Indicators of recent COVID-19 infection status: findings from a large occupational cohort of staff and postgraduate research students from a UK university Open
Background Researchers conducting cohort studies may wish to investigate the effect of episodes of COVID-19 illness on participants. A definitive diagnosis of COVID-19 is not always available, so studies have to rely on proxy indicators. T…
View article: Trajectories of mental health among UK university staff and postgraduate students during the pandemic
Trajectories of mental health among UK university staff and postgraduate students during the pandemic Open
Objectives The COVID-19 pandemic has disrupted the social and working lives of many. Past studies have highlighted worsening mental health during the pandemic, but often rely on small samples or infrequent follow-up. This study draws on fo…
View article: Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts – ERRATUM
Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts – ERRATUM Open
BACKGROUND: Mood disorders are characterised by pronounced symptom heterogeneity, which presents a substantial challenge both to clinical practice and research. Identification of subgroups of individuals with homogeneous symptom profiles t…
View article: Osteoporosis referral and treatment among people with severe mental illness: A ten-year data linkage study
Osteoporosis referral and treatment among people with severe mental illness: A ten-year data linkage study Open
People with SMI are more frequently prescribed medications for osteoporosis and referred to osteoporosis screening than the general population. Given the many risk factors for osteoporosis in this group, this increased rate of referrals ma…
View article: Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts
Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts Open
Background Mood disorders are characterised by pronounced symptom heterogeneity, which presents a substantial challenge both to clinical practice and research. Identification of subgroups of individuals with homogeneous symptom profiles th…
View article: Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts
Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts Open
View article: Unexplained longitudinal variability in COVID-19 antibody status by Lateral Flow Immuno-Antibody testing
Unexplained longitudinal variability in COVID-19 antibody status by Lateral Flow Immuno-Antibody testing Open
Background COVID-19 antibody testing allows population studies to classify participants by previous SARS-CoV-2 infection status. Home lateral flow immune-antibody testing devices offer a very convenient way of doing this, but relatively li…
View article: What gets recorded, counts: dementia recording in primary care compared with a specialist database
What gets recorded, counts: dementia recording in primary care compared with a specialist database Open
Background databases of electronic health records are powerful tools for dementia research, but data can be influenced by incomplete recording. We examined whether people with dementia recorded in a specialist database (from a mental healt…
View article: Sex differences in experiences of multiple traumas and mental health problems in the UK Biobank cohort
Sex differences in experiences of multiple traumas and mental health problems in the UK Biobank cohort Open
View article: Latent subtypes of manic or irritable episode symptoms in two population-based cohorts
Latent subtypes of manic or irritable episode symptoms in two population-based cohorts Open
Background Episodic changes in mood characterise disorders such as bipolar disorder, which includes distinct periods of manic excitability or irritability, along with additional symptoms experienced during these periods. Common clinical un…
View article: The King’s College London Coronavirus Health and Experiences of Colleagues at King’s Study: SARS-CoV-2 antibody response in a higher education sample
The King’s College London Coronavirus Health and Experiences of Colleagues at King’s Study: SARS-CoV-2 antibody response in a higher education sample Open
Objective To assess the feasibility of home antibody testing as part of large-scale study, the King’s College London Coronavirus Health and Experiences of Colleagues at King’s (KCL CHECK). Methods Participants of the KCL CHECK study were s…
View article: Aspirin in people with dementia, long-term benefits, and harms: a systematic review
Aspirin in people with dementia, long-term benefits, and harms: a systematic review Open
Purpose People with dementia may have indications for aspirin prescription and clinicians are asked to balance the potential risks against benefits. This review examines the evidence for the risk and benefit of long-term aspirin use in peo…
View article: Comparison of algorithm-based versus single-item diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts
Comparison of algorithm-based versus single-item diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts Open
Background Understanding and improving outcomes for people with anxiety or depression often requires large studies. To increase participation and reduce costs, such research is typically unable to utilise “gold-standard” methods to ascerta…
View article: Indicators of past COVID-19 infection status: Findings from a large occupational cohort of staff and postgraduate research students from a UK university
Indicators of past COVID-19 infection status: Findings from a large occupational cohort of staff and postgraduate research students from a UK university Open
Background Definitive diagnosis of COVID-19 requires resources frequently restricted to the severely ill. Cohort studies must rely on surrogate indicators to define cases of COVID-19 in the community. We describe the prevalence and overlap…
View article: The mental health of emergency services personnel in the UK Biobank: a comparison with the working population
The mental health of emergency services personnel in the UK Biobank: a comparison with the working population Open
Background: There is evidence that mental disorders are more frequently reported among emergency services personnel due to the stressful nature of the job in combination with a high exposure to traumatic events. However, most of thi…
View article: Severe mental illness diagnosis in English general hospitals 2006-2017: A registry linkage study
Severe mental illness diagnosis in English general hospitals 2006-2017: A registry linkage study Open
Our findings suggest that there have been improvements in recording of SMI diagnoses, but concerning under-recording, especially in minority ethnic groups, persists. Training in culturally sensitive diagnosis, expansion of liaison psychiat…
View article: The King’s College London Coronavirus Health and Experiences of Colleagues at King’s Study: SARS-CoV-2 antibody response in an occupational sample
The King’s College London Coronavirus Health and Experiences of Colleagues at King’s Study: SARS-CoV-2 antibody response in an occupational sample Open
We report test results for SARS-CoV-2 antibodies in an occupational group of postgraduate research students and current members of staff at King’s College London. Between June and July 2020, antibody testing kits were sent to n = 2296 part…
View article: The King’s College London Coronavirus Health and Experiences of Colleagues at King’s Study (KCL CHECK) protocol paper: a platform for study of the effects of coronavirus pandemic on staff and postgraduate students
The King’s College London Coronavirus Health and Experiences of Colleagues at King’s Study (KCL CHECK) protocol paper: a platform for study of the effects of coronavirus pandemic on staff and postgraduate students Open
Introduction We will use an occupational sample to study the impact of COVID-19 on current staff and postgraduate research students at a large UK university. The cohort study will address some of the key questions about COVID-19 for the in…
View article: Genetic aetiology of self-harm ideation and behaviour
Genetic aetiology of self-harm ideation and behaviour Open
View article: Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank Open
View article: Benefits and Harms of Statins in People with Dementia: A Systematic Review and Meta‐Analysis
Benefits and Harms of Statins in People with Dementia: A Systematic Review and Meta‐Analysis Open
OBJECTIVES More people with dementia also fall into the category of high vascular risk, for which a statin is usually prescribed. However, these recommendations are based on studies in people without dementia. We aimed to evaluate the evid…