Katrina L. Devick
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View article: Diagnosing Statistical Education Needs of Health Science Learners
Diagnosing Statistical Education Needs of Health Science Learners Open
Many types of health science learners, including clinical and translational scientists, students, researchers, and clinicians, seek to increase their knowledge of biostatistics. These learners are heterogeneous in their field, career stage…
View article: Collaborative biostatistics and epidemiology in academic medical centres: A survey to assess relationships with health researchers and ethical implications
Collaborative biostatistics and epidemiology in academic medical centres: A survey to assess relationships with health researchers and ethical implications Open
The role of collaborative biostatisticians and epidemiologists in academic medical centres and how their degree type, supervisor type and sex influences recognition and feelings of respect is poorly understood. We conducted a cross‐section…
View article: Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders Open
Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as a biomarker, but studies have largely focused only on core …
View article: Safety of magnetic resonance imaging in patients with cardiac implantable electronic devices with generator and lead(s) brand mismatch
Safety of magnetic resonance imaging in patients with cardiac implantable electronic devices with generator and lead(s) brand mismatch Open
Magnetic resonance imaging (MRI) is a valuable imaging modality for the assessment of both cardiac and non‐cardiac structures. With a growing population of patients with cardiovascular implantable electronic devices (CIEDs), 50%–75% of the…
View article: Bayesian kernel machine regression‐causal mediation analysis
Bayesian kernel machine regression‐causal mediation analysis Open
Greater understanding of the pathways through which an environmental mixture operates is important to design effective interventions. We present new methodology to estimate natural direct and indirect effects and controlled direct effects …
View article: The contribution of behavioral features to caregiver burden in FTLD spectrum disorders
The contribution of behavioral features to caregiver burden in FTLD spectrum disorders Open
Introduction Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders. Methods In a s…
View article: Proposed research criteria for prodromal behavioural variant frontotemporal dementia
Proposed research criteria for prodromal behavioural variant frontotemporal dementia Open
At present, no research criteria exist for the diagnosis of prodromal behavioural variant frontotemporal dementia (bvFTD), though early detection is of high research importance. Thus, we sought to develop and validate a proposed set of res…
View article: <scp>Doppler‐Guided</scp> Acoustically Active Injection Catheter
<span>Doppler‐Guided</span> Acoustically Active Injection Catheter Open
Percutaneous transendocardial injections of therapeutic agents into the myocardium may not always be effective. We used an animal model for assessing the efficacy of the injections using linoleic acid as a testing agent. Efficacious delive…
View article: The impact of patient and partner personality traits on learning success for a cognitive rehabilitation intervention for patients with MCI
The impact of patient and partner personality traits on learning success for a cognitive rehabilitation intervention for patients with MCI Open
Background One nonpharmacological intervention for persons with amnestic Mild Cognitive Impairment (MCI) is development of a compensatory memory notebook/planner system. De Wit et al. (2019) showed that global cognitive status is the prima…
View article: BKMR-CMA: A Novel R Command for Mediation Analysis in Environmental Mixture Studies
BKMR-CMA: A Novel R Command for Mediation Analysis in Environmental Mixture Studies Open
Background: Bayesian kernel machine regression (BKMR) is becoming a popular approach for studying the joint effect of environmental mixtures on health outcomes allowing for variable selection, which is particularly useful when continuous e…
View article: Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry
Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry Open
Higher adolescent levels of Mn, Pb, and Cr were associated with lower IQ scores, especially at low Cu levels. Findings also support further investigation into Cu as both beneficial and toxic for neurobehavioral outcomes. https://doi.org/10…
View article: The role of body mass index at diagnosis of colorectal cancer on Black–White disparities in survival: a density regression mediation approach
The role of body mass index at diagnosis of colorectal cancer on Black–White disparities in survival: a density regression mediation approach Open
Summary The study of racial/ethnic inequalities in health is important to reduce the uneven burden of disease. In the case of colorectal cancer (CRC), disparities in survival among non-Hispanic Whites and Blacks are well documented, and me…
View article: Association between surgery with anesthesia and cognitive decline in older adults: Analysis using shared parameter models for informative dropout
Association between surgery with anesthesia and cognitive decline in older adults: Analysis using shared parameter models for informative dropout Open
Objectives/Goals: The association between surgery with general anesthesia (exposure) and cognition (outcome) among older adults has been studied with mixed conclusions. We revisited a recent analysis to provide missing data education and d…
View article: Learning gaps among statistical competencies for clinical and translational science learners
Learning gaps among statistical competencies for clinical and translational science learners Open
Introduction: Statistical literacy is essential in clinical and translational science (CTS). Statistical competencies have been published to guide coursework design and selection for graduate students in CTS. Here, we describe common eleme…
View article: 4489 Association between surgery with general anesthesia and cognitive decline in older adults: analysis using shared parameter models for informative dropout
4489 Association between surgery with general anesthesia and cognitive decline in older adults: analysis using shared parameter models for informative dropout Open
OBJECTIVES/GOALS: Recent studies have assessed the association between surgery with general anesthesia and cognitive decline in longitudinal cohorts of older adults. Patients diagnosed with dementia more frequently drop out of these longit…
View article: An Overview of Methods to Address Distinct Research Questions on Environmental Mixtures: An Application to Persistent Organic Pollutants and Leukocyte Telomere Length
An Overview of Methods to Address Distinct Research Questions on Environmental Mixtures: An Application to Persistent Organic Pollutants and Leukocyte Telomere Length Open
OPS 21: Methodological progress in chemicals health effects research, Room 210, Floor 2, August 26, 2019, 4:30 PM - 5:30 PM Background. Multiple methods exist to analyze environmental mixtures in health studies. To illustrate the differenc…
View article: Prenatal cortisol modifies the association between maternal trauma history and child cognitive development in a sex-specific manner in an urban pregnancy cohort
Prenatal cortisol modifies the association between maternal trauma history and child cognitive development in a sex-specific manner in an urban pregnancy cohort Open
Women’s experience of trauma may cause lifelong alterations in physiological stress regulation, which can be transmitted to offspring in utero. We investigated, in a prospective pregnancy cohort, associations among maternal lifetime interp…
View article: Bayesian kernel machine causal mediation analysis
Bayesian kernel machine causal mediation analysis Open
Exposure to complex mixtures is a real-world scenario. As such, it is
important to understand the mechanisms through which a mixture operates in
order to reduce the burden of disease. Currently, there are few methods in the
causal mediatio…