Katsuhisa Horimoto
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View article: Supplementary materials from Single-Cell Analysis Reveals a CD4<sup>+</sup> T-cell Cluster That Correlates with PD-1 Blockade Efficacy
Supplementary materials from Single-Cell Analysis Reveals a CD4<sup>+</sup> T-cell Cluster That Correlates with PD-1 Blockade Efficacy Open
Legends of Supplementary Figures and Tables, and Supplementary Methods.
View article: Endothelial cells-derived SEMA3G suppresses glioblastoma stem cells by inducing c-Myc degradation
Endothelial cells-derived SEMA3G suppresses glioblastoma stem cells by inducing c-Myc degradation Open
The poor prognosis of glioblastoma (GBM) patients is attributed mainly to abundant neovascularization and presence of glioblastoma stem cells (GSCs). GSCs are preferentially localized to the perivascular niche to maintain stemness. However…
View article: Th7R Cells: CD4⁺ T-Cell Partners That Drive Tpex-Mediated Antitumor Immunity in the Tumor Microenvironment
Th7R Cells: CD4⁺ T-Cell Partners That Drive Tpex-Mediated Antitumor Immunity in the Tumor Microenvironment Open
The priming, expansion, and function of CD8⁺ T cells depend on CD4⁺ T-cell help via dendritic cells. Precursor exhausted T cells (Tpex) maintain self-renewal and supply cytotoxic CD8⁺ T cells in the tumor microenvironment (TME), but their …
View article: Src inhibition potentiates MCL-1 antagonist activity in acute myeloid leukemia
Src inhibition potentiates MCL-1 antagonist activity in acute myeloid leukemia Open
View article: Data from Single-Cell Analysis Reveals a CD4<sup>+</sup> T-cell Cluster That Correlates with PD-1 Blockade Efficacy
Data from Single-Cell Analysis Reveals a CD4<sup>+</sup> T-cell Cluster That Correlates with PD-1 Blockade Efficacy Open
CD4+ T-cell immunity helps clonal proliferation, migration, and cancer cell killing activity of CD8+ T cells and is essential in antitumor immune responses. To identify CD4+ T-cell clusters responsible for …
View article: Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes
Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes Open
Background: Recent clinical studies have suggested that the risk of developing HCC might be lower in patients with chronic hepatitis B receiving tenofovir disoproxil fumarate than in patients receiving entecavir, although there is no diffe…
View article: Synthesis and Bioevaluation of 3-(Arylmethylene)indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities
Synthesis and Bioevaluation of 3-(Arylmethylene)indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities Open
Glioblastoma is the most common brain tumor, with high recurrence and low survival rates. An integrative bioinformatics analysis demonstrated that anaplastic lymphoma kinase (ALK) is a promising therapeutic target for glioblastoma. We desi…
View article: Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening
Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening Open
We have developed a protein array system, named "Phospho-Totum", which reproduces the phosphorylation state of a sample on the array. The protein array contains 1471 proteins from 273 known signaling pathways. According to the activation d…
View article: Table S1, Table S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Table S1, Table S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Table S1. List of antibodies used for CyTOF.Table S2. Differentially expressed genes between Th7R cluster and Th1 cluster in tumor-infiltrating lymphocytes.
View article: FIGURE 2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD4+ T-cell clusters in TILs. A, TIL T cells were analyzed by mass cytometry. TIL and preoperative peripheral blood T-cell data were compiled, processed by clustering into 10 clusters, and then annotated on the basis of C…
View article: Table S1, Table S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Table S1, Table S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Table S1. List of antibodies used for CyTOF.Table S2. Differentially expressed genes between Th7R cluster and Th1 cluster in tumor-infiltrating lymphocytes.
View article: FIGURE 3 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 3 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD8+ T-cell clusters in TILs. A, Representative cell-level molecular expression using tSNE figures by mass cytometry analysis of gated CD8+CD3+ TILs and peripheral blood cells. B, FlowSOM anno…
View article: Supplementary Figure S4 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S4 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S4. The percentages of CD8+ T-cell clusters in the peripheral blood were compared before and after surgical resection in patients with no recurrence and patients with recurrence. Differences were tested by paired Welch's t-test
View article: FIGURE 1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD4+ T-cell clusters predict DFS of patients with lung cancer after surgical resection. A, Peripheral blood T cells collected from patients with lung cancer before surgery were analyzed by mass cytometry. The percentage o…
View article: Data from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Data from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Perioperative immune checkpoint inhibitors have been shown to improve prognosis in early-stage lung cancer. However, no biomarkers are known to indicate the requirement for treatment. This study aimed to identify T-cell clusters responsibl…
View article: Supplementary Figure S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S2. Kaplan-Meier analysis of disease-free survival (DFS) in patients with stage Ⅰ-Ⅱ disease (A), epidermal growth factor receptor (EGFR) wild-type disease, and EGFR mutations (B) using the threshold of preoperative %Th7R in peripheral…
View article: Supplementary Figure S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S2. Kaplan-Meier analysis of disease-free survival (DFS) in patients with stage Ⅰ-Ⅱ disease (A), epidermal growth factor receptor (EGFR) wild-type disease, and EGFR mutations (B) using the threshold of preoperative %Th7R in peripheral…
View article: Supplementary Figure S1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S1. Gating strategy of CyTOF analysis
View article: FIGURE 6 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 6 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
T-cell cluster changes after surgical resection. A, The percentages of CD62Llow CD4+ T cells and Th clusters in the CD62Llow CD4+ T-cell subpopulation were compared before and after surgic…
View article: TABLE 1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
TABLE 1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Patient characteristics
View article: FIGURE 3 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 3 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD8+ T-cell clusters in TILs. A, Representative cell-level molecular expression using tSNE figures by mass cytometry analysis of gated CD8+CD3+ TILs and peripheral blood cells. B, FlowSOM anno…
View article: Supplementary Figure S3 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S3 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S3. A: CD8+ T cells in peripheral blood collected before surgery were divided into four clusters according to CD62L and CD45RA expression and compared between no recurrence patients and recurrent patients: CD62LhighCD45RA+ naive, CD62…
View article: FIGURE 6 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 6 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
T-cell cluster changes after surgical resection. A, The percentages of CD62Llow CD4+ T cells and Th clusters in the CD62Llow CD4+ T-cell subpopulation were compared before and after surgic…
View article: FIGURE 5 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 5 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD8+ T-cell clusters in LNs. A, Representative cell-level molecular expression using tSNE figures by mass cytometry analysis of gated CD8+CD3+ draining LNs. B, FlowSOM annotation using CD45RA,…
View article: Supplementary Figure S4 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S4 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S4. The percentages of CD8+ T-cell clusters in the peripheral blood were compared before and after surgical resection in patients with no recurrence and patients with recurrence. Differences were tested by paired Welch's t-test
View article: Supplementary Figure S1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Supplementary Figure S1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Fig. S1. Gating strategy of CyTOF analysis
View article: FIGURE 5 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 5 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD8+ T-cell clusters in LNs. A, Representative cell-level molecular expression using tSNE figures by mass cytometry analysis of gated CD8+CD3+ draining LNs. B, FlowSOM annotation using CD45RA,…
View article: FIGURE 4 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 4 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD4+ T-cell clusters in LNs. A, Cells from station #12 LNs close to lung cancer tissue were analyzed by mass cytometry as draining LNs, and cells from ipsilateral mediastinal LNs were analyzed as distant LNs (n = 2…
View article: TABLE 1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
TABLE 1 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
Patient characteristics
View article: FIGURE 2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
FIGURE 2 from A Th1-like CD4<sup>+</sup> T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer Open
CD4+ T-cell clusters in TILs. A, TIL T cells were analyzed by mass cytometry. TIL and preoperative peripheral blood T-cell data were compiled, processed by clustering into 10 clusters, and then annotated on the basis of C…