Katsutoshi Yoshizato
YOU?
Author Swipe
View article: Proposal and implementation of a medical device monitoring tool usingsmartmeter lines for home healthcare
Proposal and implementation of a medical device monitoring tool usingsmartmeter lines for home healthcare Open
View article: Proposal and Implementation of an Integrated Monitoring Platform for Preventive Maintenance of Industrial Machines
Proposal and Implementation of an Integrated Monitoring Platform for Preventive Maintenance of Industrial Machines Open
In order to realise the efficient maintenance of industrial machines, Small and Medium-sized Enterprises (SMEs) need a system that utilises digital technology to handle everything from data collection to the visualisation of the collected …
View article: Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway
Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway Open
Our study first revealed that hypo-osmolarity-induced mechanotransduction enhanced calcium-mediated AKT signaling via TRPV2 activation, resulting in contributing to apoptosis resistance. The finding indicates a possible view that liver cir…
View article: Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes
Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes Open
Aims: Cell-cell interactions between hepatocytes (Hep) and other liver cells are key to maintaining liver homeostasis. Cytoglobin (CYGB), expressed exclusively by hepatic stellate cells (HSC), is essential in mitigating mitoc…
View article: Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry
Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry Open
Saliva contributes to the innate immune system, which suggests that it can prevent SARS-CoV-2 entry. We studied the ability of healthy salivary proteins to bind to angiotensin-converting enzyme 2 (ACE2) using biolayer interferometry and pu…
View article: Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species Open
View article: Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion
Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion Open
These findings revealed unexpected roles for MB and NGB in deactivating HSCs and inhibiting liver fibrosis development, suggesting that globin therapy may represent a new strategy for combating fibrotic liver disease.
View article: Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples
Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples Open
This on-chip device realizes large-area and predictable spin detection of fluorescent nanodiamonds, providing a scalable platform for quantum-sensor-based bioassay.
View article: Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species
Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species Open
Background and Aims Antifibrotic therapy remains an unmet medical need in human chronic liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein expressed in hepatic stellate cells (HSCs), the main c…
View article: The Effects of Ischemia and Hyperoxygenation on Hair Growth and Cycle
The Effects of Ischemia and Hyperoxygenation on Hair Growth and Cycle Open
Alopecia has several causes, but its relationship with ischemia/hypoxia has not yet been investigated in detail. In this study, we studied the changes of hair follicles induced by ischemia and potential effects of normobaric hyperoxygenati…
View article: TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis
TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis Open
Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species and protects cells from oxidative DNA damage. Herein, we show that the cytokine TGF-β1 downregulates human CYGB expression. This leads to oxidat…
View article: Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice
Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice Open
View article: Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling
Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling Open
Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in hepatic stellate cells (HSCs) in the liver. In addition to its gas-binding ability, CYGB is relevant to hepatic inflammation, fibrosis, and cancer bec…
View article: Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice
Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice Open
This study clarified the role of Cygb, the fourth globin in mammals originally discovered in rat hepatic stellate cells (HSCs), in cholestatic liver disease. Bile duct ligation (BDL) augmented inflammatory reactions as revealed by increase…
View article: MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice
MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice Open
The microRNA-29 (miR-29) family is known to suppress the activation of hepatic stellate cells (HSCs) and reversibly control liver fibrosis; however, the mechanism of how miR-29a controls liver fibrosis remains largely unknown. This study w…
View article: Nitration is exclusive to defense-related PR-1, PR-3 and PR-5 proteins in tobacco leaves
Nitration is exclusive to defense-related PR-1, PR-3 and PR-5 proteins in tobacco leaves Open
Protein tyrosine nitration is an important post-translational modification. A variety of nitrated proteins are reported in Arabidopsis leaves and seedlings, sunflower hypocotyls, and pea roots. The identities of nitrated proteins are speci…
View article: Absence of cytoglobin promotes multiple organ abnormalities in aged mice
Absence of cytoglobin promotes multiple organ abnormalities in aged mice Open
Cytoglobin (Cygb) was identified in hepatic stellate cells (HSCs) and pericytes of all organs; however, the effects of Cygb on cellular functions remain unclear. Here, we report spontaneous and age-dependent malformations in multiple organ…
View article: Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells
Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells Open
Cytoglobin (CYGB), a new member of the globin family, was discovered in 2001 as a protein associated with stellate cell activation (stellate cell activation-associated protein [STAP]). Knowledge of CYGB, including its crystal, gene, and pr…
View article: Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice
Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice Open
Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are critical in eliminating infection. We developed an animal model in which HBV-infected human hepatocytes are targeted by HBV-specific CTLs. After HBV inoculation in human h…
View article: Cell culture in three-dimensional lattices of hydrated collagen fibrils – its progress and perspectives
Cell culture in three-dimensional lattices of hydrated collagen fibrils – its progress and perspectives Open
Cell culture methodology has been utilized as a powerful tool to characterize cells with a presupposition that the cells in culture faithfully reproduce their in vivo phenotypes.However, it is generally recognized that the cells cultured c…
View article: Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism Open
View article: Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway Open
View article: Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model
Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model Open
No model is available for examining whether in vivo ‐damaged human hair follicles (hu‐ HF s) are rescued by transplanting cultured hu‐ HF dermal cells (dermal papilla and dermal sheath cells). Such a model might be valuable for examining w…