Kavita Desai
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View article: Phyto-Therapeutic Targeting of NF-κB Pathway in Inflammation-Linked Disorders
Phyto-Therapeutic Targeting of NF-κB Pathway in Inflammation-Linked Disorders Open
Inflammation is a vital biological response to injury and infection, but its persistence beyond resolution stages contributes to a range of chronic diseases, including arthritis, asthma and autoimmune disorders. The nuclear factor kappa-li…
View article: Integrative Role of Ayurveda, Yoga, Meditation, Sound and Mantra Therapy in Sickle Cell Disease (SCD) Management: Details and References
Integrative Role of Ayurveda, Yoga, Meditation, Sound and Mantra Therapy in Sickle Cell Disease (SCD) Management: Details and References Open
Sickle cell disease (SCD) remains a major global health burden characterized by chronic pain, inflammation, and psychosocial stress. While pharmacological approaches like hydroxyurea offer partial relief, integrative therapies including Ay…
View article: Toe Walking in a Formerly Preterm Child: Is it Just Cerebral Palsy?
Toe Walking in a Formerly Preterm Child: Is it Just Cerebral Palsy? Open
View article: PD‐L1 Expression is Mediated by microRNA Processing, Wnt/β‐Catenin Signaling, and Chemotherapy in Wilms Tumor
PD‐L1 Expression is Mediated by microRNA Processing, Wnt/β‐Catenin Signaling, and Chemotherapy in Wilms Tumor Open
Background Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD‐L1 are well documented in a…
View article: An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma Open
Mutations in the microRNA processing genes DROSHA and DICER1 drive several cancers that resemble embryonic progenitors. To understand how microRNAs regulate tumorigenesis, we ablated Drosha or Dicer1 in the developing pineal gland to emula…
View article: PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor Open
Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD-L1 are well-documented in adult cancer…
View article: Case Report Study on the Integrated Management of Sickle Cell Patient with Re-Infection of COVID-19
Case Report Study on the Integrated Management of Sickle Cell Patient with Re-Infection of COVID-19 Open
View article: Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Copy number changes
View article: Table S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
WES results
View article: Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA. In thi…
View article: Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Metabolomics
View article: Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S4 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Copy number changes
View article: Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Targeted genes
View article: Figure S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S2. (A) Mutational burden in Wilms tumors compared to other tumor types in TCGA. (B) Most common SNV types in Wilms tumors analyzed by WES. (C) SNV types in Wilms tumor compared to subtypes of renal cell carcinoma. (D)…
View article: Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Fusions
View article: Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Tumors list
View article: Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S2 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Targeted genes
View article: Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Tumors list
View article: Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
(A) Landscape of mutations identified by whole exome sequencing. (B) Variants detected by WGS in Wilms tumors. A red “g” represents gain of chromosome 8p or 12p.
View article: Table S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
MicroRNA sequencing
View article: Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S1 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
(A) Landscape of mutations identified by whole exome sequencing. (B) Variants detected by WGS in Wilms tumors. A red “g” represents gain of chromosome 8p or 12p.
View article: Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S7 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Metabolomics
View article: Supplementary Figure legends and Table names from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Supplementary Figure legends and Table names from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure legends and Table names
View article: Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S6. Metabolomics of Wilms tumors were used to determine differential abundance of metabolites, expressed as log2-fold-change in tumors with microRNA processing mutations versus without such mutations, demonstrating tha…
View article: Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Data from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA. In thi…
View article: Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S5. Structure of DROSHA RNase IIIb metal-binding pocket.
View article: Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Table S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Fusions
View article: Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S5 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S5. Structure of DROSHA RNase IIIb metal-binding pocket.
View article: Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S6 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S6. Metabolomics of Wilms tumors were used to determine differential abundance of metabolites, expressed as log2-fold-change in tumors with microRNA processing mutations versus without such mutations, demonstrating tha…
View article: Figure S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor
Figure S3 from <i>DROSHA</i> Regulates Mesenchymal Gene Expression in Wilms Tumor Open
Supplementary Figure S3. (A) GSEA of mutational classes matched to transcriptional signatures in UTSW/Westmead tumors. (B) GSEA enrichment of “hallmark” gene sets in Wilms tumors with miRNA processing mutations.