Kavita Vedhara
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View article: Experiences of living with, managing, and preventing reoccurrence of Diabetic Foot Ulcers: Restoring context and complexity to health and illness research
Experiences of living with, managing, and preventing reoccurrence of Diabetic Foot Ulcers: Restoring context and complexity to health and illness research Open
Diabetes is a major global health concern, with diabetic foot ulcers (DFUs) presenting a common complication. Interest is growing in people’s lived experiences of DFUs, including their management and prevention. Typically, research has hig…
View article: Motivational processes involved in long-term exercise engagement: A multiple case study testing Self-Determination Theory in a sample of older adults with mild cognitive impairment and early dementia
Motivational processes involved in long-term exercise engagement: A multiple case study testing Self-Determination Theory in a sample of older adults with mild cognitive impairment and early dementia Open
Exercise and physical activity are thought to confer widespread health benefits such as, slowing cognitive and physical decline and reducing falls in people with mild cognitive impairment (MCI) and early dementia. However, long-term exerci…
View article: The REDUCE Intervention: The Development of a Person‐Centred Cognitive Behavioural Intervention to Improve Ulcer Outcomes in People at Risk of Diabetic Foot Ulceration
The REDUCE Intervention: The Development of a Person‐Centred Cognitive Behavioural Intervention to Improve Ulcer Outcomes in People at Risk of Diabetic Foot Ulceration Open
Introduction Diabetic foot ulcers (DFUs) affect approximately one‐quarter of people living with diabetes. They are chronic, recur frequently and are associated with significant psychological distress and behavioural challenges. The REDUCE …
View article: Facilitators and barriers to engaging in expressive writing among health and social care professionals
Facilitators and barriers to engaging in expressive writing among health and social care professionals Open
Healthcare workers in the UK report high levels of burnout and poor wellbeing, and interventions are urgently needed to address this issue. Expressive writing, whereby individuals write about emotionally laden thoughts or experiences, is a…
View article: Quantifying diagnostic intervals and routes to diagnosis for children and young people with cancer in the UK (Childhood Cancer Diagnosis study, CCD): a population-based observational study
Quantifying diagnostic intervals and routes to diagnosis for children and young people with cancer in the UK (Childhood Cancer Diagnosis study, CCD): a population-based observational study Open
National Institute for Health and Social Care Research (NIHR) DRF-2018-11-ST2-055.
View article: Effectiveness of Relaxation and Hypnosis Interventions in Distressed Patients With Chronic Diabetic Foot Ulcers: A Longitudinal Pilot Randomised Controlled Trial
Effectiveness of Relaxation and Hypnosis Interventions in Distressed Patients With Chronic Diabetic Foot Ulcers: A Longitudinal Pilot Randomised Controlled Trial Open
Diabetic foot ulcer (DFU) healing is a complex and slow process that depends on several factors such as the patient's physical health. However, psychological factors such as distress, which are commonly reported by patients with DFU, may a…
View article: Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study
Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study Open
View article: Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening
Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening Open
The role of biomarkers in risk-based early detection of lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example of such a blood-based autoantibody biomarker which may improve accessibili…
View article: Integrating human behaviour and epidemiological modelling: unlocking the remaining challenges
Integrating human behaviour and epidemiological modelling: unlocking the remaining challenges Open
This paper is part of a special issue on Behavioural Epidemiology.
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\nHistorically, responses to health-related emergencies (whether public health, veterinary health or plant health related) have exposed the deficiencies of mathematical …
View article: Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study
Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study Open
This paper is part of a special issue on Behavioural Epidemiology.
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\nAim: We use the Remote Assessment of Disease and Relapses platform (RADAR) to collect Bluetooth contact and location data from university students. We test the ability…
View article: Facilitators and barriers to engaging in expressive writing among health and social care professionals
Facilitators and barriers to engaging in expressive writing among health and social care professionals Open
Healthcare workers in the UK report high levels of burnout and poor wellbeing, and interventions are urgently needed to address this issue. Expressive writing, whereby individuals write about emotionally laden thoughts or experiences, is a…
View article: A review calling for research directed at early detection of childhood cancers: The clinical, scientific, and economic arguments for population screening and surveillance
A review calling for research directed at early detection of childhood cancers: The clinical, scientific, and economic arguments for population screening and surveillance Open
Childhood cancers are increasingly recognised as disorders of tissue growth and development, through early life into adulthood. A rising proportion are currently considered to be related to a familial predisposition or associated with iden…
View article: Improved five year mortality in an RCT of a lung cancer biomarker to select people for screening
Improved five year mortality in an RCT of a lung cancer biomarker to select people for screening Open
Risk-based early detection should be cost effective and widely accessible. EarlyCDT-Lung is a blood-based autoantibody biomarker which may improve accessibility to Low dose CT screening. We randomized 12 208 individuals aged 50-75 at high …
View article: Mental health conditions and COVID-19 vaccine outcomes: A scoping review
Mental health conditions and COVID-19 vaccine outcomes: A scoping review Open
Evidence for the association between COVID-19 vaccine intentions and mental health conditions is mixed. Vaccine uptake might be lower in people with mental health conditions compared to people without, yielding interventions to encourage v…
View article: Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study
Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study Open
The COVID-19 pandemic and consequent lockdowns had a substantial impact on mental health. Distress and fatigue are highly correlated. However, little is known about the determinants of fatigue in the general population during the pandemic.…
View article: Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy
Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy Open
Introduction Smoking during pregnancy is harmful to unborn babies, infants and women. Nicotine replacement therapy (NRT) is offered as the usual stop-smoking support in the UK. However, this is often used in insufficient doses, intermitten…
View article: Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases
Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases Open
Objective To explore the acceptability of an individualized risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Metho…
View article: Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study
Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study Open
Patients with diabetic foot ulcers have poor adherence to treatment recommendations. However, the most effective way to support adherence in this population is unknown. This study aimed to assess the preliminary effectiveness of a motivati…
View article: Changes in hair cortisol in a New Zealand community sample during the Covid-19 pandemic
Changes in hair cortisol in a New Zealand community sample during the Covid-19 pandemic Open
Background
\nEvidence suggests that countries with higher Covid-19 infection rates experienced poorer mental health. This study examined whether hair cortisol reduced over time in New Zealand, a country that managed to eliminate the virus …
View article: Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions
Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions Open
Diabetic foot ulcers (DFUs) impact a substantial proportion of patients with diabetes, with high recurrence rates, severe complications, and significant financial burden to health care systems. Adherence to treatment advice (e.g., limiting…
View article: Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial.
Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial. Open
Brief psychological interventions can improve mood prior to vaccination. However, altering antibody responses to highly immunogenic adjuvanted vaccines may require more targeted or prolonged interventions. The provision of choice did not n…
View article: Development of a resource-use measure to capture costs of diabetic foot ulcers to the United Kingdom National Health Service, patients and society
Development of a resource-use measure to capture costs of diabetic foot ulcers to the United Kingdom National Health Service, patients and society Open
Background: Diabetic foot ulcers (DFUs) add a significant burden to the lives of people with diabetes in the United Kingdom. They can have a considerable impact on a patient’s daily life, with treatment requiring frequent changes of dressi…
View article: Mental health conditions and COVID-19 vaccine outcomes: a scoping review
Mental health conditions and COVID-19 vaccine outcomes: a scoping review Open
Background The COVID-19 pandemic has had a profound impact on the mental health of people worldwide. Mental health also impacts on physical health. In the context of viral illnesses, viral challenge studies have shown that indices of menta…
View article: Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial
Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial Open
Objective To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care. Design Randomised controlled trial. Setting Participa…
View article: The facilitators and barriers to improving functional activity and wellbeing in people with dementia: a qualitative study from the process evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED)
The facilitators and barriers to improving functional activity and wellbeing in people with dementia: a qualitative study from the process evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED) Open
Background The PRomoting Activity, Independence and Stability in Early Dementia (PrAISED) study delivered an exercise and functional activity programme to participants living with dementia. A Randomised Controlled Trial showed no measurabl…
View article: Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’
Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’ Open
In 2018, the World Health Organization declared childhood cancer as a global disease burden, launching a Global Initiative to improve survival to 60% worldwide by 2030. If achieved, it is estimated that an extra 1 million children’s lives …
View article: Adherence to limiting weight‐bearing activity in patients with diabetic foot ulcers: A qualitative study
Adherence to limiting weight‐bearing activity in patients with diabetic foot ulcers: A qualitative study Open
Patients with diabetic foot ulcers are advised to limit weight‐bearing activity for ulcers to heal. Patients often disregard this advice although the reasons are not yet fully understood. This study explored (1) patients' experiences of re…
View article: Influence of setting-dependent contacts and protective behaviours on asymptomatic SARS-CoV-2 infection amongst members of a UK university
Influence of setting-dependent contacts and protective behaviours on asymptomatic SARS-CoV-2 infection amongst members of a UK university Open
View article: Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study
Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study Open
View article: Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process
Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process Open
Background The incidence of childhood cancer has risen by 15% since the 1990s. Early diagnosis is key to optimising outcomes, however diagnostic delays are widely reported. Presenting symptoms are often non-specific causing a diagnostic di…