Kavitha Rajendran
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View article: Recent Advances in Natural and Nanoparticle-Based Therapies for Naegleria fowleri Infections
Recent Advances in Natural and Nanoparticle-Based Therapies for Naegleria fowleri Infections Open
Primary amoebic meningoencephalitis (PAM), caused by Naegleria fowleri, remains an aggressively fatal infection with often ineffectual treatment avenues. This study reviews the antiamoebic efficacy of natural-derived compounds, including p…
View article: Nanoparticle-Terpene Fusion: A Game-Changer in Combating Primary Amoebic Meningoencephalitis Caused by <i>Naegleria fowleri</i>
Nanoparticle-Terpene Fusion: A Game-Changer in Combating Primary Amoebic Meningoencephalitis Caused by <i>Naegleria fowleri</i> Open
Pathogenic Naegleria fowleri (N. fowleri) are opportunistic free-living amoebae and are the causative agents of a very rare but severe brain infection called primary amoebic meningoencephalitis (PAM). The fatality rate of PAM…
View article: Additional file 13 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 13 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 13. Summary of BRI GWAS results. BRI GWAS SNPs (P<10-5) identified through GWAS of bronchial responsiveness index (BRI) in the Hutterites.
View article: Additional file 8 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 8 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 8. Genes that are DE in one group (cases or controls) that are not DE in the other group. Differentially expressed genes following cytokine exposure compared to baseline (vehicle) in cases or controls (FDR<5%) that are not …
View article: Additional file 16 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 16 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 16. List of coQTLs identified through GWAS in ASMCs. coQTLs (P
View article: Additional file 4 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 4 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 4. List of differentially expressed genes in response to cytokine exposure (FDR<1%). Transcripts differentially expressed in response to IL-13 and/or IL-17 compared to vehicle (FDR<1%).
View article: Additional file 19 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 19 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 19. Loci enriched in the UK Biobank childhood-onset asthma GWAS. Summary of the 99 loci enriched in UK Biobank childhood-onset asthma GWAS.
View article: Additional file 6 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 6 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 6. Differentially expressed genes that are also associated with asthma (GWAS catalog). Genes previously identified as being associated with asthma were compared to the list of genes differentially expressed in response to I…
View article: Additional file 14 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 14 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 14. List of eQTL results (FDR=5%). eQTLs identified in IL-13 and/or IL-17A-exposed ASMCs at an FDR of 5%.
View article: Additional file 15 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Additional file 15 of Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma Open
Additional file 15. List of meQTL results (FDR=5%). meQTLs identified in IL-13 and/or IL-17A-exposed ASMCs at an FDR of 5%.
View article: Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids
Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids Open
View article: Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity
Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity Open
The cAMP response element binding protein (CREB) is induced during fasting in the liver, where it stimulates transcription of rate-limiting gluconeogenic genes to maintain metabolic homeostasis. Adenoviral and transgenic CREB reporters hav…
View article: Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity
Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity Open