Kavya Raghunathan
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View article: Developmental roles of astrocytes in circuit wiring
Developmental roles of astrocytes in circuit wiring Open
Astrocytes, the perisynaptic glial cells of the brain, play fundamental roles in sculpting synaptic circuits and instructing their remodeling and maturation during development. Astrocytes do so through a plethora of cell adhesion and secre…
View article: Prolonged STAT1 activation in neurons drives a pathological transcriptional response
Prolonged STAT1 activation in neurons drives a pathological transcriptional response Open
View article: Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages Open
Human genome variation contributes to diversity in neurodevelopmental outcomes and vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require scalable approaches. Here, we describe a "cell village" experimen…
View article: Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues Open
View article: Efficient generation of lower induced Motor Neurons by coupling <i>Ngn2</i> expression with developmental cues
Efficient generation of lower induced Motor Neurons by coupling <i>Ngn2</i> expression with developmental cues Open
SUMMARY Human pluripotent stem cells (hPSCs) are a powerful tool for disease modelling and drug discovery, especially when access to primary tissue is limited, such as in the brain. Current neuronal differentiation approaches use either sm…
View article: Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells
Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells Open
SUMMARY Variation in the human genome contributes to abundant diversity in human traits and vulnerabilities, but the underlying molecular and cellular mechanisms are not yet known, and will need scalable approaches to accelerate their reco…
View article: Mapping genetic effects on cellular phenotypes with “cell villages”
Mapping genetic effects on cellular phenotypes with “cell villages” Open
Summary Tens of thousands of genetic variants shape human phenotypes, mostly by unknown cellular mechanisms. Here we describe Census-seq, a way to measure cellular phenotypes in cells from many people simultaneously. Analogous to pooled CR…