Kay A. Ramsay
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View article: Profiling of <i>Burkholderia pseudomallei</i> variants derived from Queensland’s clinical isolates
Profiling of <i>Burkholderia pseudomallei</i> variants derived from Queensland’s clinical isolates Open
Burkholderia pseudomallei ( Bp ), an environmental bacterium and opportunistic pathogen endemic to tropical regions, is highly adaptive and thrives in diverse environments, from soil to human hosts. Bacterial adaptation is critical for sur…
View article: Co-isolation of genetically distinct Burkholderia pseudomallei strains from a single patient in North Queensland
Co-isolation of genetically distinct Burkholderia pseudomallei strains from a single patient in North Queensland Open
While investigating colony morphology variation within clinical isolates of Burkholderia pseudomallei ( Bp) isolated from a single clinical infection, we identified two distinct strains (based on their multi-locus sequence type) from Bp TS…
View article: Co-isolation of genetically distinct <i>Burkholderia pseudomallei</i> strains from a single patient in North Queensland
Co-isolation of genetically distinct <i>Burkholderia pseudomallei</i> strains from a single patient in North Queensland Open
While investigating colony morphology variation (CMV) within clinical isolates of Burkholderia pseudomallei ( Bp ) isolated from a single infection, we identified two distinct strains (based on their multi-locus sequence type) from Bp TSV2…
View article: Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection
Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection Open
Carbapenem-resistant Enterobacterales pose a critical global health threat, exemplified by increasing resistance of uropathogenic E. coli (UPEC) that cause urinary tract infections (UTIs). Here, we investigate the publicly available Entero…
View article: Profiling of <i>Burkholderia pseudomallei</i> variants derived from Queensland’s clinical isolates
Profiling of <i>Burkholderia pseudomallei</i> variants derived from Queensland’s clinical isolates Open
Burkholderia pseudomallei ( Bp ), an environmental bacterium and opportunistic pathogen endemic to tropical regions, is highly adaptive and thrives in diverse environments, from soil to human hosts. Bacterial adaptation is critical for sur…
View article: Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae
Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae Open
BACKGROUND-AIM: Although ceftazidime/avibactam is the agent of choice in OXA-48-producing Klebsiella pneumoniae infections, it is not readily available or prohibitively expensive in many countries. Since piperacillin/tazobactam plus merope…
View article: Ceftazidime resistance in Pseudomonas aeruginosa is multigenic and complex
Ceftazidime resistance in Pseudomonas aeruginosa is multigenic and complex Open
Pseudomonas aeruginosa causes a wide range of severe infections. Ceftazidime, a cephalosporin, is a key antibiotic for treating infections but a significant proportion of isolates are ceftazidime-resistant. The aim of this research was to …
View article: Rapid fluoroquinolone resistance detection in Pseudomonas aeruginosa using mismatch amplification mutation assay-based real-time PCR
Rapid fluoroquinolone resistance detection in Pseudomonas aeruginosa using mismatch amplification mutation assay-based real-time PCR Open
Background. Antimicrobial resistance (AMR) is an ever-increasing global health concern. One crucial facet in tackling the AMR epidemic is earlier and more accurate AMR diagnosis, particularly in the dangerous and highly multi-drug-resistan…
View article: Express Yourself: Quantitative Real-Time PCR Assays for Rapid Chromosomal Antimicrobial Resistance Detection in Pseudomonas aeruginosa
Express Yourself: Quantitative Real-Time PCR Assays for Rapid Chromosomal Antimicrobial Resistance Detection in Pseudomonas aeruginosa Open
The rise of antimicrobial-resistant (AMR) bacteria is a global health emergency. One critical facet of tackling this epidemic is more rapid AMR diagnosis in serious multidrug-resistant pathogens like Pseudomonas aeruginosa .
View article: Express yourself: Quantitative real-time PCR assays for rapid chromosomal antimicrobial resistance detection in <i>Pseudomonas aeruginosa</i>
Express yourself: Quantitative real-time PCR assays for rapid chromosomal antimicrobial resistance detection in <i>Pseudomonas aeruginosa</i> Open
The rise of antimicrobial-resistant (AMR) bacteria is a global health emergency. One critical facet in tackling this epidemic is more rapid AMR diagnosis in serious multi-drug resistant pathogens like Pseudomonas aeruginosa . Here, we desi…
View article: Genomic diversity and antimicrobial resistance of Prevotella species isolated from chronic lung disease airways
Genomic diversity and antimicrobial resistance of Prevotella species isolated from chronic lung disease airways Open
Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterized by increasingly frequent acute pulmonary exacerbations that reduce life quality and length. Human airways are home to a rich polymicrobial environment,…
View article: The Effects of Sub-inhibitory Antibiotic Concentrations on Pseudomonas aeruginosa: Reduced Susceptibility Due to Mutations
The Effects of Sub-inhibitory Antibiotic Concentrations on Pseudomonas aeruginosa: Reduced Susceptibility Due to Mutations Open
Pseudomonas aeruginosa chronically infects in the lungs of people with cystic fibrosis and other forms of lung disease. Infections are treated with antibiotics, but over time, the bacteria acquire mutations that reduce their antibiotic sus…
View article: Rapid fluoroquinolone resistance detection in<i>Pseudomonas aeruginosa</i>using mismatch amplification mutation assay-based real-time PCR
Rapid fluoroquinolone resistance detection in<i>Pseudomonas aeruginosa</i>using mismatch amplification mutation assay-based real-time PCR Open
Background Antimicrobial resistance (AMR) is an ever-increasing global health concern. One crucial facet in tackling the AMR epidemic is earlier and more accurate AMR diagnosis, particularly in the dangerous and highly multi-drug resistant…
View article: Genomic diversity and antimicrobial resistance of <i>Prevotella</i> spp. isolated from chronic lung disease airways
Genomic diversity and antimicrobial resistance of <i>Prevotella</i> spp. isolated from chronic lung disease airways Open
Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterised by increasingly frequent acute pulmonary exacerbations that reduce life quality and length. Human airways are home to a rich polymicrobial environment,…
View article: Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium Open
Lung infections with Mycobacterium abscessus, a species of multidrug resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF) where they accelerate inflammatory lung damage …
View article: Prevalence and impact of <i>oprD</i> mutations in <i>Pseudomonas aeruginosa</i> strains in cystic fibrosis
Prevalence and impact of <i>oprD</i> mutations in <i>Pseudomonas aeruginosa</i> strains in cystic fibrosis Open
Defective OprD porins contribute to carbapenem resistance and may be important in Pseudomonas aeruginosa adaptation to cystic fibrosis airways. It is unclear whether oprD mutations are fixed in populations of shared strains that are transm…
View article: Correction: Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis
Correction: Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis Open
[This corrects the article DOI: 10.1371/journal.pone.0172179.].
View article: Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients
Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients Open
The lungs of individuals with cystic fibrosis (CF) become chronically infected with Pseudomonas aeruginosa that is difficult to eradicate by antibiotic treatment. Two key P. aeruginosa antibiotic resistance mechanisms are the AmpC β-lactam…
View article: Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei
Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei Open
The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non- P…
View article: Whole genome sequencing reveals the emergence of a<i>Pseudomonas aeruginosa</i>shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Whole genome sequencing reveals the emergence of a<i>Pseudomonas aeruginosa</i>shared strain sub-lineage among patients treated within a single cystic fibrosis centre Open
Background Chronic lung infections by Pseudomonas aeruginosa are a significant cause of morbidity and mortality in people with cystic fibrosis (CF). Shared P. aeruginosa strains, that can be transmitted between patients, are of concern and…
View article: Additional file 8: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Additional file 8: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre Open
Table S4. Position and details of non-synonymous SNPs (nâ =â 35) and indels (nâ =â 9) that characterise the M3L7 sub-lineage. (XLSX 13 kb)
View article: Additional file 9: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Additional file 9: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre Open
Table S5. Table of variants (SNPs and indels) that vary across 37Â M3L7 genomes and 1Â M3L1 (AUS970) genome. Table generated with nesoni nway. Only positions with a consensus determined for all strains (â -require-all yes) are shown. Only …
View article: Additional file 4: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Additional file 4: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre Open
Table S2. Overlapping admissions to a hospital ward for patients and first detection of M3L7. (XLSX 10 kb)
View article: Additional file 1: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Additional file 1: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre Open
Table S1. Details of Pseudomonas aeruginosa isolates and genome assembly metrics used in this study. (XLSX 14 kb)
View article: Additional file 5: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Additional file 5: of Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre Open
Table S3. Details of co-pathogens in people with M3L7/M3L1 infection at time of isolation and in the previous 12Â months. (XLSX 11 kb)