Kay Boulton
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View article: Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition, and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these process…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processe…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processe…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition, and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these process…
View article: Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds
Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds Open
Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processe…
View article: Parental methyl-enhanced diet and in ovo corticosterone affect first generation Japanese quail (Coturnix coturnix japonica) development, behaviour and stress response.
Parental methyl-enhanced diet and in ovo corticosterone affect first generation Japanese quail (Coturnix coturnix japonica) development, behaviour and stress response. Open
The role of maternal investment on avian offspring has considerable life history implications on production traits and therefore potential for the poultry industry. A first generation (G1) of Japanese quail (Coturnix coturnix japonica) wer…
View article: Analysis of the Progeny of Sibling Matings Reveals Regulatory Variation Impacting the Transcriptome of Immune Cells in Commercial Chickens
Analysis of the Progeny of Sibling Matings Reveals Regulatory Variation Impacting the Transcriptome of Immune Cells in Commercial Chickens Open
There is increasing recognition that the underlying genetic variation contributing to complex traits influences transcriptional regulation and can be detected at a population level as expression quantitative trait loci. At the level of an …
View article: Variant discovery from whole genome sequence data from a commercial broiler line and a CSFIR- mApple reporter transgenic layer line
Variant discovery from whole genome sequence data from a commercial broiler line and a CSFIR- mApple reporter transgenic layer line Open
The data comprises variants calls from whole genome sequencing (WGS) data from a set of founder broilers (n=10) and transgenic layers (n=10). The broiler samples belong to commercial Ross 308 founder population and were sourced from PD Hoo…
View article: Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken
Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken Open
Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher co…
View article: Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis
Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis Open
Eigenanalysis separated the phenotypic impact of a defined challenge with E. tenella on WG, caecal inflammation/pathology, and production of IL-10 into three major eigenvectors, indicating that the susceptibility-resistance axis is not a s…
View article: MOESM3 of Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis
MOESM3 of Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis Open
Additional file 3: Table S2. Univariate linear model analyses performed in ASReml 4.0 were used to predict the means (PM) of the fixed effects on each of the measured traits, with standard errors (Âąâ SE) and significance (P value).
View article: Phenotypic and genetic integration of personality and growth under competition in the sheepshead swordtail, <i>Xiphophorus birchmanni</i>
Phenotypic and genetic integration of personality and growth under competition in the sheepshead swordtail, <i>Xiphophorus birchmanni</i> Open
Competition for resources including food, physical space, and potential mates is a fundamental ecological process shaping variation in individual phenotype and fitness. The evolution of competitive ability, in particular social dominance, …
View article: Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology
Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology Open
Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken heal…
View article: Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA
Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA Open
In mammals, the inducible cytokine interleukin 10 is a feedback negative regulator of inflammation. To determine the extent to which this function is conserved in birds, recombinant chicken IL-10 was expressed as a secreted human Ig Fc fus…