Kay H. M. Roumans
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View article: Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes Open
View article: A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial
A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial Open
Objective Increasing overnight fasting time seems a promising strategy to improve metabolic health in individuals with nonalcoholic fatty liver (NAFL). Mechanisms underlying the beneficial effects of fasting may be related to larger fluctu…
View article: Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions
Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions Open
Background: Current guidelines aim to limit the dietary glycemic index (GI) and intake of saturated fatty acids (SFA). Several studies have shown favorable effects of low-GI or low-SFA diets on intrahepatic lipid content (IHL), but these s…
View article: Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial
Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial Open
View article: Metabolic responses to mild cold acclimation in type 2 diabetes patients
Metabolic responses to mild cold acclimation in type 2 diabetes patients Open
Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients wi…
View article: Liver fat storage pathways: methodologies and dietary effects
Liver fat storage pathways: methodologies and dietary effects Open
Purpose of review Nonalcoholic fatty liver is the result of an imbalance between lipid storage [from meal, de novo lipogenesis (DNL) and fatty acid (FA) uptake] and disposal (oxidation and VLDL output). Knowledge on the contribution of eac…
View article: Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials
Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials Open
View article: Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance Open
View article: Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans Open
View article: The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity
The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity Open