Kay M. Tye
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View article: Author response: Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state
Author response: Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state Open
View article: Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state Open
Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However,…
View article: Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State
Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State Open
Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However,…
View article: Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation
Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation Open
View article: Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation
Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation Open
The “Pain Overlap Theory” (1) proposes that the experience of social pain overlaps with and amplifies the experience of physical pain by sharing parts of the same underlying processing systems (2–6). In humans, the insular cortex has been …
View article: Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state
Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state Open
Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However,…
View article: Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state Open
Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However,…
View article: Long-term editing of brain circuits in mice using an engineered electrical synapse
Long-term editing of brain circuits in mice using an engineered electrical synapse Open
Electrical signaling across distinct populations of brain cells underpins cognitive and emotional function; however, approaches that selectively regulate electrical signaling between two cellular components of a mammalian neural circuit re…
View article: Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression
Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression Open
The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line therapies that are ineffective or burdened with undesirable side effects. One major obstac…
View article: Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State
Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State Open
Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However,…
View article: Control of innate olfactory valence by segregated cortical amygdala circuits
Control of innate olfactory valence by segregated cortical amygdala circuits Open
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These behaviors can be reduced to an axis of valence, whereby specific odors evoke …
View article: Control of innate olfactory valence by segregated cortical amygdala circuits
Control of innate olfactory valence by segregated cortical amygdala circuits Open
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These behaviors can be reduced to an axis of valence, whereby specific odors evoke …
View article: Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression
Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression Open
The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line therapies that are ineffective or burdened with undesirable side effects. One major obstac…
View article: Control of innate olfactory valence by segregated cortical amygdala circuits
Control of innate olfactory valence by segregated cortical amygdala circuits Open
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These behaviors can be reduced to an axis of valence, whereby specific odors evoke …
View article: An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior
An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior Open
In neuroscience, understanding how single-neuron firing contributes to distributed neural ensembles is crucial. Traditional methods of analysis have been limited to descriptions of whole population activity, or, when analyzing individual n…
View article: Mixed selectivity: Cellular computations for complexity
Mixed selectivity: Cellular computations for complexity Open
The property of mixed selectivity has been discussed at a computational level and offers a strategy to maximize computational power by adding versatility to the functional role of each neuron. Here, we offer a biologically grounded impleme…
View article: Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking
Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking Open
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: Control of Innate Olfactory Valence by Segregated Cortical Amygdala Circuits
Control of Innate Olfactory Valence by Segregated Cortical Amygdala Circuits Open
View article: Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking
Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking Open
How do social factors impact the brain and contribute to increased alcohol drinking? We found that social rank predicts alcohol drinking, where subordinates drink more than dominants. Furthermore, social isolation escalates alcohol drinkin…
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: Reward contingency gates selective cholinergic suppression of amygdala neurons
Reward contingency gates selective cholinergic suppression of amygdala neurons Open
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly inv…
View article: Issue Information
Issue Information Open
10,224 (Rest of World), €6,625 (Europe), £5,
View article: AlphaTracker: a multi-animal tracking and behavioral analysis tool
AlphaTracker: a multi-animal tracking and behavioral analysis tool Open
Computer vision has emerged as a powerful tool to elevate behavioral research. This protocol describes a computer vision machine learning pipeline called AlphaTracker, which has minimal hardware requirements and produces reliable tracking …
View article: Anxiety and depression: A top‐down, bottom‐up model of circuit function
Anxiety and depression: A top‐down, bottom‐up model of circuit function Open
A functional interplay of bottom‐up and top‐down processing allows an individual to appropriately respond to the dynamic environment around them. These processing modalities can be represented as attractor states using a dynamical systems …
View article: Thalamus sends information about arousal but not valence to the amygdala
Thalamus sends information about arousal but not valence to the amygdala Open
View article: Amygdalostriatal transition zone neurons encode sustained valence to direct conditioned behaviors
Amygdalostriatal transition zone neurons encode sustained valence to direct conditioned behaviors Open
SUMMARY In order to respond appropriately to threats in the environment, the brain must rapidly determine whether a stimulus is important and whether it is positive or negative, and then use that information to direct behavioral responses.…
View article: Neurotensin orchestrates valence assignment in the amygdala
Neurotensin orchestrates valence assignment in the amygdala Open
View article: Thalamus sends information about arousal but not valence to the amygdala
Thalamus sends information about arousal but not valence to the amygdala Open
Rationale The basolateral amygdala (BLA) and medial geniculate nucleus of the thalamus (MGN) have both been shown to be necessary for the formation of associative learning. While the role that the BLA plays in this process has long been em…
View article: Dynamic influences on the neural encoding of social valence
Dynamic influences on the neural encoding of social valence Open