Paul K.S. Chan
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View article: MOMMY study profile: An integrative early‐life multi‐omics cohort in China
MOMMY study profile: An integrative early‐life multi‐omics cohort in China Open
Large‐scale, prospective birth cohorts capturing the complex interplay between the gut microbiome, host biology, and environmental exposures are crucial to understanding early‐life health but remain scarce, particularly within Asian popula…
View article: Treatment landscape and outcome of myeloproliferative neoplasms in asia: Interim analysis of the Asian myeloproliferative neoplasm registry
Treatment landscape and outcome of myeloproliferative neoplasms in asia: Interim analysis of the Asian myeloproliferative neoplasm registry Open
Background Large multicenter analysis of myeloproliferative neoplasms (MPNs) has not been conducted in Asia. Aims This project aims to define the clinicopathologic characteristics, treatment landscape and outcome of MPNs in Asia. Methods T…
View article: Monopoly of Minor Group Rhinovirus Infections in Hospitalised Children in Hong Kong During the SARS-CoV-2 Pandemic
Monopoly of Minor Group Rhinovirus Infections in Hospitalised Children in Hong Kong During the SARS-CoV-2 Pandemic Open
Background: While rhinoviruses (RVs) typically cause mild respiratory infections, their persistence during the SARS-CoV-2 pandemic, particularly in Hong Kong’s strict zero-coronavirus disease 2019 policy, revealed unexpected epidemiologica…
View article: Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair
Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair Open
The recovery of neurological function following spinal cord injury (SCI) is primarily constrained by two core pathological mechanisms: neuroinflammation and impaired tissue regeneration. While extracellular vesicles (EVs) have emerged as a…
View article: Chronic post-COVID neuropsychiatric symptoms persisting more than 1 year after infection during the ‘Omicron wave’
Chronic post-COVID neuropsychiatric symptoms persisting more than 1 year after infection during the ‘Omicron wave’ Open
Background The heterogeneity of chronic post-COVID neuropsychiatric symptoms (PCNPS), especially after infection by the Omicron strain, has not been adequately explored. Aims To explore the clustering pattern of chronic PCNPS in a cohort o…
View article: Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis
Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis Open
Patients with attention-deficit hyperactivity disorder (ADHD) reported significantly more constipation and flatulence than healthy controls. An altered gut microbiome can be associated with gastrointestinal symptoms. However, comprehensive…
View article: Post-pandemic excess mortality of COVID-19 in Hong Kong: a retrospective study
Post-pandemic excess mortality of COVID-19 in Hong Kong: a retrospective study Open
Health and Medical Research Fund.
View article: Global epidemiology, seasonality and climatic drivers of the four human parainfluenza virus types
Global epidemiology, seasonality and climatic drivers of the four human parainfluenza virus types Open
Climate drivers may play a role in hPIV transmission. More comprehensive and coherent surveillance of hPIV types would enable more in-depth analyses and inform the timing of preventive measures.
View article: Inter-individual variability in the metabolism of psychotropic drugs by the enzyme activities from the human gut microbiome
Inter-individual variability in the metabolism of psychotropic drugs by the enzyme activities from the human gut microbiome Open
The interaction between marketed drugs and the gut microbiome is increasingly being recognized, and it is now known that enzymes produced by the bacteria in the human gut can degrade psychotropic drugs. However, the degree of inter-individ…
View article: Impacts of COVID-19 pandemic on early life gut microbiome
Impacts of COVID-19 pandemic on early life gut microbiome Open
Increased hygiene and sanitation are theorized to predispose to developing atopic diseases, a process potentially mediated by the gut microbiome. We hypothesized that the gut microbiome maturation has been altered by COVID-19 lockdown meas…
View article: Generation of Inheritable A-to-G Transitions Using Adenine Base Editing and NG-PAM Cas9 in <i>Arabidopsis thaliana</i>
Generation of Inheritable A-to-G Transitions Using Adenine Base Editing and NG-PAM Cas9 in <i>Arabidopsis thaliana</i> Open
Towards precise genome editing, base editors have been developed by fusing catalytically compromised Cas9 with deaminase components, mediating C-to-T (cytosine base editors) or A-to-G (adenine base editors) transition. We developed a set o…
View article: Respiratory Viral Infection Patterns in Hospitalised Children Before and After COVID-19 in Hong Kong
Respiratory Viral Infection Patterns in Hospitalised Children Before and After COVID-19 in Hong Kong Open
The study highlights the significant changes in respiratory virus epidemiology following the lifting of COVID-19 restrictions. Method: In this single-centre retrospective study, the virological readouts of adenovirus (AdV), influenza virus…
View article: Chronic post-COVID neuropsychiatric symptoms (PCNPS) persisting beyond one year from being infected during the ‘Omicron wave’
Chronic post-COVID neuropsychiatric symptoms (PCNPS) persisting beyond one year from being infected during the ‘Omicron wave’ Open
The heterogeneity of chronic post-COVID neuropsychiatric symptoms (PCNPS), especially after infection by the Omicron strain, has not been adequately explored. Our pre-registered hypotheses are 1. chronic PCNPS in patients infected with SAR…
View article: Early Metabolomic and Immunologic Biomarkers as Prognostic Indicators for COVID-19
Early Metabolomic and Immunologic Biomarkers as Prognostic Indicators for COVID-19 Open
This prospective study in Hong Kong aimed at identifying prognostic metabolomic and immunologic biomarkers for Coronavirus Disease 2019 (COVID-19). We examined 327 patients, mean age 55 (19–89) years, in whom 33.6% were infected with Omicr…
View article: Respiratory Viral Infection Patterns in Hospitalised Children before and after COVID-19 in Hong Kong
Respiratory Viral Infection Patterns in Hospitalised Children before and after COVID-19 in Hong Kong Open
In the wake of Hong Kong’s zero-COVID policy, this study comprehensively analyses the epidemiological shift in respiratory viruses among hospitalized pediatric patients. The research leverages a unique natural experiment created by the pol…
View article: Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations
Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations Open
Influenza virus continuously evolves to escape human adaptive immunity and generates seasonal epidemics. Therefore, influenza vaccine strains need to be updated annually for the upcoming flu season to ensure vaccine effectiveness. We devel…
View article: Genetic association of COVID-19 severe versus non-severe cases by RNA sequencing in patients hospitalised in Hong Kong
Genetic association of COVID-19 severe versus non-severe cases by RNA sequencing in patients hospitalised in Hong Kong Open
RNA sequencing analysis showed that severe acute respiratory syndrome coronavirus 2 infection is associated with the overexpression of genes involved in nervous system disorders.
View article: Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G
Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G Open
The SARS-CoV-2 Omicron variants are notorious for their transmissibility, but little is known about their subgenomic RNA (sgRNA) expression. This study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgR…
View article: Prevalence of oral human papillomavirus infection among the general adult population in Hong Kong
Prevalence of oral human papillomavirus infection among the general adult population in Hong Kong Open
A cross‐sectional study in 2021−23 collected oral rinse gargle samples from an human papillomaviruses (HPV) vaccine‐naïve general adult population in Hong Kong. HPV was detected by a PCR using SPF10 primers, and genotyped by a linear array…
View article: Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients
Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients Open
Introduction There is insufficient understanding on systemic interferon (IFN) responses during COVID-19 infection. Early reports indicated that interferon responses were suppressed by the coronavirus (SARS-CoV-2) and clinical trials of adm…
View article: Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong
Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong Open
The incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is rising in the West, but little is known in Asia. This study elucidated changes in the incidence and HPV-positive portion of OPSCC in Ho…